| Full name: zinc finger protein 431 | Alias Symbol: KIAA1969 | ||
| Type: protein-coding gene | Cytoband: 19p12 | ||
| Entrez ID: 170959 | HGNC ID: HGNC:20809 | Ensembl Gene: ENSG00000196705 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ZNF431:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZNF431 | 170959 | 232338_at | -0.5749 | 0.6850 | |
| GSE26886 | ZNF431 | 170959 | 244663_at | -2.5189 | 0.0000 | |
| GSE45670 | ZNF431 | 170959 | 232338_at | -1.1304 | 0.0065 | |
| GSE53622 | ZNF431 | 170959 | 25525 | -2.5195 | 0.0000 | |
| GSE53624 | ZNF431 | 170959 | 25525 | -2.2551 | 0.0000 | |
| GSE63941 | ZNF431 | 170959 | 232338_at | 0.2046 | 0.8579 | |
| GSE77861 | ZNF431 | 170959 | 232338_at | -0.6019 | 0.5962 | |
| SRP007169 | ZNF431 | 170959 | RNAseq | -3.5378 | 0.0000 | |
| SRP008496 | ZNF431 | 170959 | RNAseq | -3.4796 | 0.0000 | |
| SRP064894 | ZNF431 | 170959 | RNAseq | -2.8542 | 0.0000 | |
| SRP133303 | ZNF431 | 170959 | RNAseq | -1.1882 | 0.0001 | |
| SRP159526 | ZNF431 | 170959 | RNAseq | -1.7373 | 0.0000 | |
| SRP193095 | ZNF431 | 170959 | RNAseq | -2.0666 | 0.0000 | |
| SRP219564 | ZNF431 | 170959 | RNAseq | -1.9272 | 0.0079 | |
| TCGA | ZNF431 | 170959 | RNAseq | -0.0871 | 0.4754 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by ZNF431 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZNF431:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZNF431 | 170959 | 4 | 5 | 21 | |
| GSE20123 | ZNF431 | 170959 | 4 | 3 | 23 | |
| GSE43470 | ZNF431 | 170959 | 2 | 6 | 35 | |
| GSE46452 | ZNF431 | 170959 | 47 | 1 | 11 | |
| GSE47630 | ZNF431 | 170959 | 7 | 7 | 26 | |
| GSE54993 | ZNF431 | 170959 | 17 | 3 | 50 | |
| GSE54994 | ZNF431 | 170959 | 6 | 13 | 34 | |
| GSE60625 | ZNF431 | 170959 | 9 | 0 | 2 | |
| GSE74703 | ZNF431 | 170959 | 2 | 4 | 30 | |
| GSE74704 | ZNF431 | 170959 | 1 | 3 | 16 | |
| TCGA | ZNF431 | 170959 | 15 | 13 | 68 |
Total number of gains: 114; Total number of losses: 58; Total Number of normals: 316.
Somatic mutations of ZNF431:
Generating mutation plots.
Highly correlated genes for ZNF431:
Showing top 20/1205 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZNF431 | CTTNBP2 | 0.833767 | 4 | 0 | 4 |
| ZNF431 | SORT1 | 0.801689 | 4 | 0 | 4 |
| ZNF431 | KIAA0232 | 0.790544 | 4 | 0 | 4 |
| ZNF431 | FAM214A | 0.778107 | 5 | 0 | 5 |
| ZNF431 | ULK3 | 0.773498 | 5 | 0 | 5 |
| ZNF431 | EHD3 | 0.772993 | 5 | 0 | 5 |
| ZNF431 | CHP1 | 0.770616 | 5 | 0 | 5 |
| ZNF431 | OSTF1 | 0.770064 | 5 | 0 | 5 |
| ZNF431 | EPS8L2 | 0.769958 | 5 | 0 | 5 |
| ZNF431 | PLEKHM1 | 0.769815 | 5 | 0 | 5 |
| ZNF431 | C6orf132 | 0.768891 | 5 | 0 | 5 |
| ZNF431 | ZNF430 | 0.768499 | 7 | 0 | 7 |
| ZNF431 | STK24 | 0.767104 | 4 | 0 | 4 |
| ZNF431 | LPIN1 | 0.767059 | 5 | 0 | 5 |
| ZNF431 | EVPL | 0.766764 | 5 | 0 | 5 |
| ZNF431 | SLC46A2 | 0.760175 | 5 | 0 | 5 |
| ZNF431 | SLC16A6 | 0.759715 | 5 | 0 | 5 |
| ZNF431 | SLC7A4 | 0.755268 | 3 | 0 | 3 |
| ZNF431 | RMND5B | 0.754858 | 5 | 0 | 5 |
| ZNF431 | C1orf116 | 0.754777 | 5 | 0 | 5 |
For details and further investigation, click here
