| Full name: cordon-bleu WH2 repeat protein | Alias Symbol: KIAA0633 | ||
| Type: protein-coding gene | Cytoband: 7p12.1 | ||
| Entrez ID: 23242 | HGNC ID: HGNC:22199 | Ensembl Gene: ENSG00000106078 | OMIM ID: 610317 |
| Drug and gene relationship at DGIdb | |||
Expression of COBL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COBL | 23242 | 213050_at | -2.3418 | 0.0216 | |
| GSE20347 | COBL | 23242 | 213050_at | -1.9671 | 0.0000 | |
| GSE23400 | COBL | 23242 | 213050_at | -1.0589 | 0.0000 | |
| GSE26886 | COBL | 23242 | 213050_at | -1.4790 | 0.0000 | |
| GSE29001 | COBL | 23242 | 213050_at | -1.9171 | 0.0001 | |
| GSE38129 | COBL | 23242 | 213050_at | -2.0517 | 0.0000 | |
| GSE45670 | COBL | 23242 | 213050_at | -1.4358 | 0.0012 | |
| GSE53622 | COBL | 23242 | 8973 | -2.8483 | 0.0000 | |
| GSE53624 | COBL | 23242 | 8973 | -2.2437 | 0.0000 | |
| GSE63941 | COBL | 23242 | 213050_at | 1.1410 | 0.3934 | |
| GSE77861 | COBL | 23242 | 213050_at | -0.6513 | 0.0339 | |
| GSE97050 | COBL | 23242 | A_33_P3327673 | -1.4466 | 0.1399 | |
| SRP007169 | COBL | 23242 | RNAseq | -2.0978 | 0.0023 | |
| SRP008496 | COBL | 23242 | RNAseq | -2.0525 | 0.0000 | |
| SRP064894 | COBL | 23242 | RNAseq | -2.0403 | 0.0000 | |
| SRP133303 | COBL | 23242 | RNAseq | -1.2815 | 0.0306 | |
| SRP159526 | COBL | 23242 | RNAseq | -1.8369 | 0.0000 | |
| SRP193095 | COBL | 23242 | RNAseq | -1.5329 | 0.0000 | |
| SRP219564 | COBL | 23242 | RNAseq | -1.1505 | 0.1348 | |
| TCGA | COBL | 23242 | RNAseq | -1.2479 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by COBL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COBL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COBL | 23242 | 13 | 0 | 17 | |
| GSE20123 | COBL | 23242 | 11 | 0 | 19 | |
| GSE43470 | COBL | 23242 | 4 | 1 | 38 | |
| GSE46452 | COBL | 23242 | 11 | 1 | 47 | |
| GSE47630 | COBL | 23242 | 8 | 1 | 31 | |
| GSE54993 | COBL | 23242 | 0 | 8 | 62 | |
| GSE54994 | COBL | 23242 | 14 | 3 | 36 | |
| GSE60625 | COBL | 23242 | 0 | 0 | 11 | |
| GSE74703 | COBL | 23242 | 4 | 1 | 31 | |
| GSE74704 | COBL | 23242 | 5 | 0 | 15 | |
| TCGA | COBL | 23242 | 49 | 9 | 38 |
Total number of gains: 119; Total number of losses: 24; Total Number of normals: 345.
Somatic mutations of COBL:
Generating mutation plots.
Highly correlated genes for COBL:
Showing top 20/1654 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COBL | CLEC3B | 0.790666 | 3 | 0 | 3 |
| COBL | CYP21A2 | 0.790134 | 3 | 0 | 3 |
| COBL | SHROOM3 | 0.786008 | 7 | 0 | 7 |
| COBL | CTTNBP2 | 0.77453 | 6 | 0 | 6 |
| COBL | SORT1 | 0.769463 | 11 | 0 | 11 |
| COBL | KIAA0232 | 0.769369 | 11 | 0 | 11 |
| COBL | KAT2B | 0.768506 | 11 | 0 | 11 |
| COBL | ANGPTL1 | 0.765143 | 5 | 0 | 5 |
| COBL | ID4 | 0.764705 | 9 | 0 | 9 |
| COBL | HSPB8 | 0.759558 | 11 | 0 | 11 |
| COBL | BTC | 0.759316 | 10 | 0 | 10 |
| COBL | CAB39L | 0.757871 | 11 | 0 | 11 |
| COBL | ARHGAP10 | 0.754656 | 11 | 0 | 11 |
| COBL | KIAA1211L | 0.754005 | 6 | 0 | 6 |
| COBL | MTMR10 | 0.750772 | 7 | 0 | 7 |
| COBL | LMBRD1 | 0.748703 | 11 | 0 | 11 |
| COBL | SNORA68 | 0.746832 | 4 | 0 | 4 |
| COBL | ZNF662 | 0.745676 | 7 | 0 | 7 |
| COBL | MGLL | 0.745137 | 11 | 0 | 11 |
| COBL | ARHGEF10L | 0.743904 | 11 | 0 | 11 |
For details and further investigation, click here
