| Full name: VPS37C subunit of ESCRT-I | Alias Symbol: FLJ20847 | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 55048 | HGNC ID: HGNC:26097 | Ensembl Gene: ENSG00000167987 | OMIM ID: 610038 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS37C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS37C | 55048 | 1560060_s_at | -0.0152 | 0.9740 | |
| GSE20347 | VPS37C | 55048 | 219053_s_at | 0.1620 | 0.1149 | |
| GSE23400 | VPS37C | 55048 | 219053_s_at | 0.1645 | 0.0023 | |
| GSE26886 | VPS37C | 55048 | 1560060_s_at | -0.0390 | 0.8194 | |
| GSE29001 | VPS37C | 55048 | 219053_s_at | -0.0961 | 0.7415 | |
| GSE38129 | VPS37C | 55048 | 219053_s_at | 0.1158 | 0.2309 | |
| GSE45670 | VPS37C | 55048 | 1560060_s_at | -0.0171 | 0.9078 | |
| GSE53622 | VPS37C | 55048 | 37952 | -0.2187 | 0.0032 | |
| GSE53624 | VPS37C | 55048 | 37952 | 0.0070 | 0.9091 | |
| GSE63941 | VPS37C | 55048 | 1560060_s_at | 0.5257 | 0.2123 | |
| GSE77861 | VPS37C | 55048 | 1560060_s_at | 0.2394 | 0.0528 | |
| GSE97050 | VPS37C | 55048 | A_23_P47517 | -0.0078 | 0.9759 | |
| SRP007169 | VPS37C | 55048 | RNAseq | -0.7019 | 0.0456 | |
| SRP008496 | VPS37C | 55048 | RNAseq | -0.9442 | 0.0000 | |
| SRP064894 | VPS37C | 55048 | RNAseq | -0.2731 | 0.0291 | |
| SRP133303 | VPS37C | 55048 | RNAseq | -0.0101 | 0.9623 | |
| SRP159526 | VPS37C | 55048 | RNAseq | -0.0628 | 0.7966 | |
| SRP193095 | VPS37C | 55048 | RNAseq | -0.1532 | 0.2346 | |
| SRP219564 | VPS37C | 55048 | RNAseq | -0.2250 | 0.3764 | |
| TCGA | VPS37C | 55048 | RNAseq | -0.1687 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS37C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS37C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS37C | 55048 | 3 | 5 | 22 | |
| GSE20123 | VPS37C | 55048 | 3 | 5 | 22 | |
| GSE43470 | VPS37C | 55048 | 2 | 6 | 35 | |
| GSE46452 | VPS37C | 55048 | 8 | 4 | 47 | |
| GSE47630 | VPS37C | 55048 | 3 | 8 | 29 | |
| GSE54993 | VPS37C | 55048 | 3 | 0 | 67 | |
| GSE54994 | VPS37C | 55048 | 5 | 5 | 43 | |
| GSE60625 | VPS37C | 55048 | 0 | 3 | 8 | |
| GSE74703 | VPS37C | 55048 | 2 | 3 | 31 | |
| GSE74704 | VPS37C | 55048 | 2 | 3 | 15 | |
| TCGA | VPS37C | 55048 | 15 | 10 | 71 |
Total number of gains: 46; Total number of losses: 52; Total Number of normals: 390.
Somatic mutations of VPS37C:
Generating mutation plots.
Highly correlated genes for VPS37C:
Showing top 20/100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS37C | DYNLRB1 | 0.741973 | 3 | 0 | 3 |
| VPS37C | MED26 | 0.739267 | 3 | 0 | 3 |
| VPS37C | NDRG3 | 0.730722 | 3 | 0 | 3 |
| VPS37C | ZNF211 | 0.730585 | 3 | 0 | 3 |
| VPS37C | POP5 | 0.722792 | 3 | 0 | 3 |
| VPS37C | HIRA | 0.717926 | 3 | 0 | 3 |
| VPS37C | SDAD1 | 0.701902 | 3 | 0 | 3 |
| VPS37C | INPP5B | 0.701116 | 3 | 0 | 3 |
| VPS37C | NFXL1 | 0.696487 | 3 | 0 | 3 |
| VPS37C | TLK2 | 0.688817 | 3 | 0 | 3 |
| VPS37C | DAZAP1 | 0.687012 | 4 | 0 | 3 |
| VPS37C | TXNL4A | 0.685933 | 3 | 0 | 3 |
| VPS37C | ZNF689 | 0.676955 | 3 | 0 | 3 |
| VPS37C | NAA30 | 0.670621 | 3 | 0 | 3 |
| VPS37C | CDK10 | 0.668459 | 3 | 0 | 3 |
| VPS37C | ZNF407 | 0.658375 | 3 | 0 | 3 |
| VPS37C | HGS | 0.65186 | 5 | 0 | 3 |
| VPS37C | SYTL2 | 0.650501 | 3 | 0 | 3 |
| VPS37C | TMEM62 | 0.647967 | 3 | 0 | 3 |
| VPS37C | LEMD2 | 0.644421 | 4 | 0 | 3 |
For details and further investigation, click here
