| Full name: mitochondrial ribosomal protein S18B | Alias Symbol: MRPS18-2|PTD017|C6orf14|HSPC183 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 28973 | HGNC ID: HGNC:14516 | Ensembl Gene: ENSG00000204568 | OMIM ID: 611982 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPS18B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS18B | 28973 | 217408_at | 0.1652 | 0.7008 | |
| GSE20347 | MRPS18B | 28973 | 217408_at | 0.2621 | 0.0126 | |
| GSE23400 | MRPS18B | 28973 | 208907_s_at | 0.1827 | 0.0063 | |
| GSE26886 | MRPS18B | 28973 | 217408_at | 0.3980 | 0.0463 | |
| GSE29001 | MRPS18B | 28973 | 217408_at | 0.3705 | 0.2323 | |
| GSE38129 | MRPS18B | 28973 | 217408_at | 0.3883 | 0.0001 | |
| GSE45670 | MRPS18B | 28973 | 217408_at | 0.2500 | 0.0539 | |
| GSE53622 | MRPS18B | 28973 | 121319 | 0.1326 | 0.0146 | |
| GSE53624 | MRPS18B | 28973 | 121319 | 0.4870 | 0.0000 | |
| GSE63941 | MRPS18B | 28973 | 217408_at | 0.5369 | 0.2654 | |
| GSE77861 | MRPS18B | 28973 | 217408_at | -0.2828 | 0.1432 | |
| GSE97050 | MRPS18B | 28973 | A_23_P59107 | 0.0827 | 0.6701 | |
| SRP007169 | MRPS18B | 28973 | RNAseq | -0.0826 | 0.8051 | |
| SRP008496 | MRPS18B | 28973 | RNAseq | -0.2219 | 0.2895 | |
| SRP064894 | MRPS18B | 28973 | RNAseq | 0.2818 | 0.1616 | |
| SRP133303 | MRPS18B | 28973 | RNAseq | 0.0400 | 0.7469 | |
| SRP159526 | MRPS18B | 28973 | RNAseq | 0.0843 | 0.6052 | |
| SRP193095 | MRPS18B | 28973 | RNAseq | -0.0979 | 0.3136 | |
| SRP219564 | MRPS18B | 28973 | RNAseq | 0.6568 | 0.1420 | |
| TCGA | MRPS18B | 28973 | RNAseq | -0.0008 | 0.9865 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPS18B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPS18B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS18B | 28973 | 5 | 1 | 24 | |
| GSE20123 | MRPS18B | 28973 | 5 | 1 | 24 | |
| GSE43470 | MRPS18B | 28973 | 5 | 1 | 37 | |
| GSE46452 | MRPS18B | 28973 | 1 | 10 | 48 | |
| GSE47630 | MRPS18B | 28973 | 7 | 3 | 30 | |
| GSE54993 | MRPS18B | 28973 | 2 | 1 | 67 | |
| GSE54994 | MRPS18B | 28973 | 11 | 4 | 38 | |
| GSE60625 | MRPS18B | 28973 | 0 | 1 | 10 | |
| GSE74703 | MRPS18B | 28973 | 5 | 0 | 31 | |
| GSE74704 | MRPS18B | 28973 | 2 | 0 | 18 | |
| TCGA | MRPS18B | 28973 | 18 | 16 | 62 |
Total number of gains: 61; Total number of losses: 38; Total Number of normals: 389.
Somatic mutations of MRPS18B:
Generating mutation plots.
Highly correlated genes for MRPS18B:
Showing top 20/515 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS18B | ANKRD28 | 0.794339 | 3 | 0 | 3 |
| MRPS18B | DYRK2 | 0.781197 | 3 | 0 | 3 |
| MRPS18B | ZNF764 | 0.764522 | 3 | 0 | 3 |
| MRPS18B | PPCS | 0.761717 | 3 | 0 | 3 |
| MRPS18B | TBC1D8 | 0.754339 | 3 | 0 | 3 |
| MRPS18B | PPIP5K2 | 0.747322 | 3 | 0 | 3 |
| MRPS18B | GFM2 | 0.73699 | 3 | 0 | 3 |
| MRPS18B | MYSM1 | 0.735237 | 3 | 0 | 3 |
| MRPS18B | DMAP1 | 0.733591 | 3 | 0 | 3 |
| MRPS18B | STT3B | 0.725727 | 3 | 0 | 3 |
| MRPS18B | MBD1 | 0.72541 | 3 | 0 | 3 |
| MRPS18B | TRUB1 | 0.718992 | 3 | 0 | 3 |
| MRPS18B | ZNF564 | 0.717783 | 3 | 0 | 3 |
| MRPS18B | NDRG3 | 0.717152 | 4 | 0 | 4 |
| MRPS18B | LEMD2 | 0.715736 | 3 | 0 | 3 |
| MRPS18B | NIPBL | 0.715513 | 3 | 0 | 3 |
| MRPS18B | ZNF700 | 0.712878 | 3 | 0 | 3 |
| MRPS18B | SMARCC1 | 0.708358 | 4 | 0 | 3 |
| MRPS18B | ZNF570 | 0.708248 | 3 | 0 | 3 |
| MRPS18B | CMTM6 | 0.708105 | 3 | 0 | 3 |
For details and further investigation, click here
