| Full name: NEDD4 E3 ubiquitin protein ligase | Alias Symbol: KIAA0093|MGC176705|NEDD4-1|RPF1 | ||
| Type: protein-coding gene | Cytoband: 15q21.3 | ||
| Entrez ID: 4734 | HGNC ID: HGNC:7727 | Ensembl Gene: ENSG00000069869 | OMIM ID: 602278 |
| Drug and gene relationship at DGIdb | |||
NEDD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05169 | Epstein-Barr virus infection |
Expression of NEDD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEDD4 | 4734 | 213012_at | -0.0072 | 0.9946 | |
| GSE20347 | NEDD4 | 4734 | 213012_at | 0.1563 | 0.4839 | |
| GSE23400 | NEDD4 | 4734 | 213012_at | 0.1731 | 0.0020 | |
| GSE26886 | NEDD4 | 4734 | 213012_at | 0.0064 | 0.9825 | |
| GSE29001 | NEDD4 | 4734 | 213012_at | 0.2901 | 0.3807 | |
| GSE38129 | NEDD4 | 4734 | 213012_at | 0.0114 | 0.9582 | |
| GSE45670 | NEDD4 | 4734 | 213012_at | 0.1260 | 0.5971 | |
| GSE53622 | NEDD4 | 4734 | 72584 | 0.3567 | 0.0004 | |
| GSE53624 | NEDD4 | 4734 | 45874 | 0.3332 | 0.0001 | |
| GSE63941 | NEDD4 | 4734 | 213012_at | 0.0326 | 0.9717 | |
| GSE77861 | NEDD4 | 4734 | 213012_at | 0.1194 | 0.5304 | |
| GSE97050 | NEDD4 | 4734 | A_32_P160883 | 0.1714 | 0.5641 | |
| SRP007169 | NEDD4 | 4734 | RNAseq | 0.3833 | 0.2808 | |
| SRP008496 | NEDD4 | 4734 | RNAseq | 0.4074 | 0.0721 | |
| SRP064894 | NEDD4 | 4734 | RNAseq | 0.7662 | 0.0104 | |
| SRP133303 | NEDD4 | 4734 | RNAseq | 0.8315 | 0.0008 | |
| SRP159526 | NEDD4 | 4734 | RNAseq | 0.1634 | 0.6876 | |
| SRP193095 | NEDD4 | 4734 | RNAseq | 0.7796 | 0.0000 | |
| SRP219564 | NEDD4 | 4734 | RNAseq | 0.6660 | 0.1245 | |
| TCGA | NEDD4 | 4734 | RNAseq | 0.1276 | 0.0920 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NEDD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEDD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEDD4 | 4734 | 6 | 3 | 21 | |
| GSE20123 | NEDD4 | 4734 | 6 | 3 | 21 | |
| GSE43470 | NEDD4 | 4734 | 4 | 3 | 36 | |
| GSE46452 | NEDD4 | 4734 | 3 | 7 | 49 | |
| GSE47630 | NEDD4 | 4734 | 8 | 10 | 22 | |
| GSE54993 | NEDD4 | 4734 | 5 | 6 | 59 | |
| GSE54994 | NEDD4 | 4734 | 5 | 8 | 40 | |
| GSE60625 | NEDD4 | 4734 | 4 | 0 | 7 | |
| GSE74703 | NEDD4 | 4734 | 4 | 2 | 30 | |
| GSE74704 | NEDD4 | 4734 | 2 | 3 | 15 | |
| TCGA | NEDD4 | 4734 | 11 | 16 | 69 |
Total number of gains: 58; Total number of losses: 61; Total Number of normals: 369.
Somatic mutations of NEDD4:
Generating mutation plots.
Highly correlated genes for NEDD4:
Showing top 20/292 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEDD4 | TSHZ3 | 0.699161 | 3 | 0 | 3 |
| NEDD4 | SLC39A13 | 0.663583 | 3 | 0 | 3 |
| NEDD4 | GLIS2 | 0.658586 | 4 | 0 | 3 |
| NEDD4 | FKBP7 | 0.654156 | 3 | 0 | 3 |
| NEDD4 | TAF1L | 0.653297 | 3 | 0 | 3 |
| NEDD4 | ARPP19 | 0.651003 | 11 | 0 | 9 |
| NEDD4 | CAPRIN1 | 0.645695 | 3 | 0 | 3 |
| NEDD4 | RAB34 | 0.638717 | 3 | 0 | 3 |
| NEDD4 | FHOD3 | 0.633667 | 4 | 0 | 4 |
| NEDD4 | KIF7 | 0.626704 | 3 | 0 | 3 |
| NEDD4 | FAM168B | 0.624296 | 4 | 0 | 3 |
| NEDD4 | PLEKHA3 | 0.621652 | 3 | 0 | 3 |
| NEDD4 | GLT8D2 | 0.613441 | 6 | 0 | 5 |
| NEDD4 | DCTN4 | 0.613027 | 3 | 0 | 3 |
| NEDD4 | CSNK2A2 | 0.612959 | 3 | 0 | 3 |
| NEDD4 | MORF4L1 | 0.61272 | 10 | 0 | 8 |
| NEDD4 | ROCK2 | 0.607732 | 9 | 0 | 7 |
| NEDD4 | SOCS5 | 0.606991 | 8 | 0 | 5 |
| NEDD4 | OAZ2 | 0.603682 | 5 | 0 | 3 |
| NEDD4 | EHBP1L1 | 0.603612 | 4 | 0 | 3 |
For details and further investigation, click here
