| Full name: kinesin family member 7 | Alias Symbol: JBTS12 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 374654 | HGNC ID: HGNC:30497 | Ensembl Gene: ENSG00000166813 | OMIM ID: 611254 |
| Drug and gene relationship at DGIdb | |||
KIF7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of KIF7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIF7 | 374654 | 229405_at | 0.1343 | 0.7523 | |
| GSE26886 | KIF7 | 374654 | 229405_at | 0.7712 | 0.0002 | |
| GSE45670 | KIF7 | 374654 | 229405_at | 0.1170 | 0.4640 | |
| GSE53622 | KIF7 | 374654 | 29266 | 0.6841 | 0.0000 | |
| GSE53624 | KIF7 | 374654 | 29266 | 0.8209 | 0.0000 | |
| GSE63941 | KIF7 | 374654 | 229405_at | -0.8800 | 0.0947 | |
| GSE77861 | KIF7 | 374654 | 229405_at | 0.1201 | 0.5000 | |
| GSE97050 | KIF7 | 374654 | A_24_P203689 | -0.2515 | 0.3758 | |
| SRP064894 | KIF7 | 374654 | RNAseq | 0.4805 | 0.0214 | |
| SRP133303 | KIF7 | 374654 | RNAseq | 0.7561 | 0.0257 | |
| SRP159526 | KIF7 | 374654 | RNAseq | 1.8135 | 0.0008 | |
| SRP193095 | KIF7 | 374654 | RNAseq | 1.3194 | 0.0000 | |
| SRP219564 | KIF7 | 374654 | RNAseq | 0.5849 | 0.3733 | |
| TCGA | KIF7 | 374654 | RNAseq | 0.1403 | 0.3964 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KIF7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIF7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIF7 | 374654 | 8 | 2 | 20 | |
| GSE20123 | KIF7 | 374654 | 8 | 2 | 20 | |
| GSE43470 | KIF7 | 374654 | 5 | 4 | 34 | |
| GSE46452 | KIF7 | 374654 | 3 | 7 | 49 | |
| GSE47630 | KIF7 | 374654 | 8 | 11 | 21 | |
| GSE54993 | KIF7 | 374654 | 4 | 6 | 60 | |
| GSE54994 | KIF7 | 374654 | 7 | 6 | 40 | |
| GSE60625 | KIF7 | 374654 | 4 | 0 | 7 | |
| GSE74703 | KIF7 | 374654 | 4 | 3 | 29 | |
| GSE74704 | KIF7 | 374654 | 4 | 2 | 14 | |
| TCGA | KIF7 | 374654 | 17 | 12 | 67 |
Total number of gains: 72; Total number of losses: 55; Total Number of normals: 361.
Somatic mutations of KIF7:
Generating mutation plots.
Highly correlated genes for KIF7:
Showing top 20/253 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIF7 | SOD3 | 0.749363 | 3 | 0 | 3 |
| KIF7 | MARVELD1 | 0.734195 | 5 | 0 | 5 |
| KIF7 | DMTN | 0.699856 | 3 | 0 | 3 |
| KIF7 | TMEM151A | 0.689793 | 3 | 0 | 3 |
| KIF7 | GYG1 | 0.684098 | 3 | 0 | 3 |
| KIF7 | PPP1R14A | 0.682104 | 3 | 0 | 3 |
| KIF7 | EGR3 | 0.66443 | 4 | 0 | 4 |
| KIF7 | CEBPD | 0.656907 | 4 | 0 | 4 |
| KIF7 | TOX | 0.655921 | 3 | 0 | 3 |
| KIF7 | DDN | 0.653119 | 3 | 0 | 3 |
| KIF7 | QRFPR | 0.647748 | 3 | 0 | 3 |
| KIF7 | FBN1 | 0.645526 | 3 | 0 | 3 |
| KIF7 | SMAD9 | 0.64547 | 3 | 0 | 3 |
| KIF7 | PTPN9 | 0.643787 | 5 | 0 | 4 |
| KIF7 | PRUNE2 | 0.638206 | 4 | 0 | 4 |
| KIF7 | OBSL1 | 0.629232 | 4 | 0 | 3 |
| KIF7 | CLCF1 | 0.62777 | 4 | 0 | 3 |
| KIF7 | NEDD4 | 0.626704 | 3 | 0 | 3 |
| KIF7 | CEP290 | 0.621213 | 3 | 0 | 3 |
| KIF7 | ARMC9 | 0.621061 | 4 | 0 | 4 |
For details and further investigation, click here
