| Full name: bradykinin receptor B1 | Alias Symbol: BKR1|B1BKR|bradyb1 | ||
| Type: protein-coding gene | Cytoband: 14q32.2 | ||
| Entrez ID: 623 | HGNC ID: HGNC:1029 | Ensembl Gene: ENSG00000100739 | OMIM ID: 600337 |
| Drug and gene relationship at DGIdb | |||
BDKRB1 involved pathways:
Expression of BDKRB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BDKRB1 | 623 | 207510_at | -0.8246 | 0.2566 | |
| GSE20347 | BDKRB1 | 623 | 207510_at | -0.7230 | 0.0035 | |
| GSE23400 | BDKRB1 | 623 | 207510_at | -0.3184 | 0.0000 | |
| GSE26886 | BDKRB1 | 623 | 207510_at | -1.7613 | 0.0001 | |
| GSE29001 | BDKRB1 | 623 | 207510_at | -1.0310 | 0.0093 | |
| GSE38129 | BDKRB1 | 623 | 207510_at | -0.6259 | 0.0032 | |
| GSE45670 | BDKRB1 | 623 | 207510_at | -0.1194 | 0.7654 | |
| GSE53622 | BDKRB1 | 623 | 7924 | -1.0533 | 0.0000 | |
| GSE53624 | BDKRB1 | 623 | 7924 | -1.2830 | 0.0000 | |
| GSE63941 | BDKRB1 | 623 | 207510_at | -4.6969 | 0.0001 | |
| GSE77861 | BDKRB1 | 623 | 207510_at | -0.6389 | 0.0257 | |
| GSE97050 | BDKRB1 | 623 | A_23_P128744 | 0.4135 | 0.2600 | |
| SRP007169 | BDKRB1 | 623 | RNAseq | -3.8690 | 0.0000 | |
| SRP008496 | BDKRB1 | 623 | RNAseq | -2.7666 | 0.0003 | |
| SRP064894 | BDKRB1 | 623 | RNAseq | -0.8502 | 0.0056 | |
| SRP133303 | BDKRB1 | 623 | RNAseq | -1.0152 | 0.0000 | |
| SRP159526 | BDKRB1 | 623 | RNAseq | -1.7567 | 0.0001 | |
| SRP219564 | BDKRB1 | 623 | RNAseq | -0.9014 | 0.1054 | |
| TCGA | BDKRB1 | 623 | RNAseq | 0.1221 | 0.5493 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by BDKRB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BDKRB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BDKRB1 | 623 | 10 | 4 | 16 | |
| GSE20123 | BDKRB1 | 623 | 10 | 3 | 17 | |
| GSE43470 | BDKRB1 | 623 | 8 | 3 | 32 | |
| GSE46452 | BDKRB1 | 623 | 16 | 3 | 40 | |
| GSE47630 | BDKRB1 | 623 | 11 | 8 | 21 | |
| GSE54993 | BDKRB1 | 623 | 3 | 8 | 59 | |
| GSE54994 | BDKRB1 | 623 | 21 | 4 | 28 | |
| GSE60625 | BDKRB1 | 623 | 0 | 2 | 9 | |
| GSE74703 | BDKRB1 | 623 | 6 | 3 | 27 | |
| GSE74704 | BDKRB1 | 623 | 6 | 3 | 11 | |
| TCGA | BDKRB1 | 623 | 30 | 19 | 47 |
Total number of gains: 121; Total number of losses: 60; Total Number of normals: 307.
Somatic mutations of BDKRB1:
Generating mutation plots.
Highly correlated genes for BDKRB1:
Showing top 20/817 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BDKRB1 | BDKRB2 | 0.801428 | 13 | 0 | 13 |
| BDKRB1 | MAP4K4 | 0.749923 | 3 | 0 | 3 |
| BDKRB1 | TRIM61 | 0.74188 | 3 | 0 | 3 |
| BDKRB1 | YAP1 | 0.734381 | 3 | 0 | 3 |
| BDKRB1 | EPG5 | 0.721931 | 3 | 0 | 3 |
| BDKRB1 | ZFYVE16 | 0.718765 | 3 | 0 | 3 |
| BDKRB1 | ESYT2 | 0.714072 | 3 | 0 | 3 |
| BDKRB1 | PDLIM2 | 0.705925 | 9 | 0 | 8 |
| BDKRB1 | NEK1 | 0.70279 | 3 | 0 | 3 |
| BDKRB1 | PPIP5K2 | 0.702349 | 3 | 0 | 3 |
| BDKRB1 | BTBD1 | 0.697697 | 3 | 0 | 3 |
| BDKRB1 | FIBIN | 0.694635 | 3 | 0 | 3 |
| BDKRB1 | MAN2B2 | 0.691481 | 4 | 0 | 4 |
| BDKRB1 | VPS37A | 0.690422 | 3 | 0 | 3 |
| BDKRB1 | ETS1 | 0.688436 | 4 | 0 | 4 |
| BDKRB1 | WDFY1 | 0.685741 | 4 | 0 | 4 |
| BDKRB1 | GANC | 0.68532 | 7 | 0 | 7 |
| BDKRB1 | ARHGEF6 | 0.6845 | 4 | 0 | 3 |
| BDKRB1 | ZNF844 | 0.684351 | 4 | 0 | 4 |
| BDKRB1 | CNOT4 | 0.683285 | 3 | 0 | 3 |
For details and further investigation, click here
