| Full name: solute carrier family 12 member 4 | Alias Symbol: KCC1 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 6560 | HGNC ID: HGNC:10913 | Ensembl Gene: ENSG00000124067 | OMIM ID: 604119 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC12A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC12A4 | 6560 | 209402_s_at | 0.2811 | 0.5705 | |
| GSE20347 | SLC12A4 | 6560 | 211112_at | 0.0437 | 0.6729 | |
| GSE23400 | SLC12A4 | 6560 | 209402_s_at | -0.0148 | 0.8009 | |
| GSE26886 | SLC12A4 | 6560 | 209402_s_at | 0.3530 | 0.0289 | |
| GSE29001 | SLC12A4 | 6560 | 209402_s_at | 0.2032 | 0.2313 | |
| GSE38129 | SLC12A4 | 6560 | 209402_s_at | 0.0164 | 0.9172 | |
| GSE45670 | SLC12A4 | 6560 | 209402_s_at | 0.1031 | 0.4798 | |
| GSE53622 | SLC12A4 | 6560 | 60782 | 0.4581 | 0.0000 | |
| GSE53624 | SLC12A4 | 6560 | 12668 | 0.6339 | 0.0000 | |
| GSE63941 | SLC12A4 | 6560 | 209402_s_at | -0.9077 | 0.0013 | |
| GSE77861 | SLC12A4 | 6560 | 209402_s_at | 0.0559 | 0.6068 | |
| GSE97050 | SLC12A4 | 6560 | A_23_P389391 | -0.1476 | 0.5934 | |
| SRP007169 | SLC12A4 | 6560 | RNAseq | 2.1337 | 0.0002 | |
| SRP008496 | SLC12A4 | 6560 | RNAseq | 1.7162 | 0.0000 | |
| SRP064894 | SLC12A4 | 6560 | RNAseq | 0.6789 | 0.0001 | |
| SRP133303 | SLC12A4 | 6560 | RNAseq | 0.3111 | 0.1358 | |
| SRP159526 | SLC12A4 | 6560 | RNAseq | 0.8922 | 0.1038 | |
| SRP193095 | SLC12A4 | 6560 | RNAseq | 1.1149 | 0.0000 | |
| SRP219564 | SLC12A4 | 6560 | RNAseq | -0.1335 | 0.7634 | |
| TCGA | SLC12A4 | 6560 | RNAseq | -0.0225 | 0.7504 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SLC12A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC12A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC12A4 | 6560 | 9 | 2 | 19 | |
| GSE20123 | SLC12A4 | 6560 | 9 | 2 | 19 | |
| GSE43470 | SLC12A4 | 6560 | 1 | 9 | 33 | |
| GSE46452 | SLC12A4 | 6560 | 38 | 1 | 20 | |
| GSE47630 | SLC12A4 | 6560 | 11 | 8 | 21 | |
| GSE54993 | SLC12A4 | 6560 | 2 | 4 | 64 | |
| GSE54994 | SLC12A4 | 6560 | 8 | 10 | 35 | |
| GSE60625 | SLC12A4 | 6560 | 4 | 0 | 7 | |
| GSE74703 | SLC12A4 | 6560 | 1 | 6 | 29 | |
| GSE74704 | SLC12A4 | 6560 | 5 | 1 | 14 | |
| TCGA | SLC12A4 | 6560 | 30 | 12 | 54 |
Total number of gains: 118; Total number of losses: 55; Total Number of normals: 315.
Somatic mutations of SLC12A4:
Generating mutation plots.
Highly correlated genes for SLC12A4:
Showing top 20/856 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC12A4 | SYNE1 | 0.827317 | 3 | 0 | 3 |
| SLC12A4 | PDE5A | 0.775965 | 3 | 0 | 3 |
| SLC12A4 | CXXC1 | 0.741609 | 3 | 0 | 3 |
| SLC12A4 | C9orf78 | 0.738222 | 3 | 0 | 3 |
| SLC12A4 | SLC39A13 | 0.736624 | 7 | 0 | 7 |
| SLC12A4 | FBN1 | 0.731203 | 4 | 0 | 4 |
| SLC12A4 | NES | 0.727851 | 5 | 0 | 5 |
| SLC12A4 | RAB34 | 0.726365 | 3 | 0 | 3 |
| SLC12A4 | CCDC127 | 0.725444 | 4 | 0 | 4 |
| SLC12A4 | ASPA | 0.723748 | 3 | 0 | 3 |
| SLC12A4 | KIF13A | 0.723068 | 3 | 0 | 3 |
| SLC12A4 | C20orf194 | 0.72186 | 3 | 0 | 3 |
| SLC12A4 | FGF7 | 0.721111 | 4 | 0 | 3 |
| SLC12A4 | MRFAP1 | 0.719053 | 3 | 0 | 3 |
| SLC12A4 | RGL1 | 0.716216 | 4 | 0 | 4 |
| SLC12A4 | CLMP | 0.714799 | 5 | 0 | 5 |
| SLC12A4 | LYVE1 | 0.710173 | 3 | 0 | 3 |
| SLC12A4 | SGTB | 0.708272 | 3 | 0 | 3 |
| SLC12A4 | RGS3 | 0.705257 | 7 | 0 | 6 |
| SLC12A4 | B3GNT9 | 0.698959 | 7 | 0 | 7 |
For details and further investigation, click here
