| Full name: nuclear factor of activated T cells 5 | Alias Symbol: TONEBP|KIAA0827|NFATL1|OREBP|NFATZ|NF-AT5 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 10725 | HGNC ID: HGNC:7774 | Ensembl Gene: ENSG00000102908 | OMIM ID: 604708 |
| Drug and gene relationship at DGIdb | |||
Expression of NFAT5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFAT5 | 10725 | 224984_at | -0.4045 | 0.4396 | |
| GSE20347 | NFAT5 | 10725 | 208003_s_at | -0.4604 | 0.0157 | |
| GSE23400 | NFAT5 | 10725 | 208003_s_at | -0.1506 | 0.1923 | |
| GSE26886 | NFAT5 | 10725 | 224984_at | 0.6165 | 0.0172 | |
| GSE29001 | NFAT5 | 10725 | 208003_s_at | -0.1879 | 0.7669 | |
| GSE38129 | NFAT5 | 10725 | 208003_s_at | -0.4019 | 0.0151 | |
| GSE45670 | NFAT5 | 10725 | 224984_at | -0.3013 | 0.0026 | |
| GSE53622 | NFAT5 | 10725 | 62364 | 0.1272 | 0.0753 | |
| GSE53624 | NFAT5 | 10725 | 62364 | -0.0193 | 0.8053 | |
| GSE63941 | NFAT5 | 10725 | 224984_at | -0.8582 | 0.0295 | |
| GSE77861 | NFAT5 | 10725 | 224984_at | 0.0878 | 0.6251 | |
| GSE97050 | NFAT5 | 10725 | A_23_P359647 | -0.1884 | 0.4509 | |
| SRP007169 | NFAT5 | 10725 | RNAseq | 0.5238 | 0.1299 | |
| SRP008496 | NFAT5 | 10725 | RNAseq | 0.4695 | 0.0338 | |
| SRP064894 | NFAT5 | 10725 | RNAseq | -0.4801 | 0.0705 | |
| SRP133303 | NFAT5 | 10725 | RNAseq | 0.0422 | 0.7586 | |
| SRP159526 | NFAT5 | 10725 | RNAseq | -0.1143 | 0.7581 | |
| SRP193095 | NFAT5 | 10725 | RNAseq | 0.2251 | 0.1907 | |
| SRP219564 | NFAT5 | 10725 | RNAseq | -0.4357 | 0.2209 | |
| TCGA | NFAT5 | 10725 | RNAseq | -0.0205 | 0.6796 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NFAT5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFAT5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFAT5 | 10725 | 8 | 1 | 21 | |
| GSE20123 | NFAT5 | 10725 | 8 | 1 | 21 | |
| GSE43470 | NFAT5 | 10725 | 2 | 7 | 34 | |
| GSE46452 | NFAT5 | 10725 | 38 | 1 | 20 | |
| GSE47630 | NFAT5 | 10725 | 11 | 8 | 21 | |
| GSE54993 | NFAT5 | 10725 | 2 | 4 | 64 | |
| GSE54994 | NFAT5 | 10725 | 8 | 9 | 36 | |
| GSE60625 | NFAT5 | 10725 | 4 | 0 | 7 | |
| GSE74703 | NFAT5 | 10725 | 2 | 4 | 30 | |
| GSE74704 | NFAT5 | 10725 | 4 | 0 | 16 | |
| TCGA | NFAT5 | 10725 | 28 | 12 | 56 |
Total number of gains: 115; Total number of losses: 47; Total Number of normals: 326.
Somatic mutations of NFAT5:
Generating mutation plots.
Highly correlated genes for NFAT5:
Showing top 20/227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFAT5 | DCTN6 | 0.747121 | 3 | 0 | 3 |
| NFAT5 | HADHB | 0.734756 | 4 | 0 | 4 |
| NFAT5 | SCAMP1 | 0.731188 | 3 | 0 | 3 |
| NFAT5 | ZDHHC17 | 0.72668 | 3 | 0 | 3 |
| NFAT5 | FKTN | 0.722108 | 3 | 0 | 3 |
| NFAT5 | PMPCB | 0.72185 | 3 | 0 | 3 |
| NFAT5 | ITFG1 | 0.719044 | 3 | 0 | 3 |
| NFAT5 | ANKRD36B | 0.714983 | 3 | 0 | 3 |
| NFAT5 | OSBPL9 | 0.713712 | 4 | 0 | 4 |
| NFAT5 | WASL | 0.712759 | 4 | 0 | 3 |
| NFAT5 | IFT74 | 0.709148 | 3 | 0 | 3 |
| NFAT5 | RLF | 0.705552 | 3 | 0 | 3 |
| NFAT5 | HERPUD2 | 0.702417 | 3 | 0 | 3 |
| NFAT5 | TCF7L2 | 0.700894 | 3 | 0 | 3 |
| NFAT5 | DEXI | 0.698954 | 3 | 0 | 3 |
| NFAT5 | ADCY7 | 0.698952 | 3 | 0 | 3 |
| NFAT5 | ELL2 | 0.695717 | 4 | 0 | 4 |
| NFAT5 | FNIP1 | 0.688361 | 6 | 0 | 6 |
| NFAT5 | PRICKLE1 | 0.685502 | 3 | 0 | 3 |
| NFAT5 | SCAPER | 0.681465 | 4 | 0 | 3 |
For details and further investigation, click here
