ADCY7

 

Full name: adenylate cyclase 7 Alias Symbol: KIAA0037|AC7
Type: protein-coding gene Cytoband: 16q12.1
Entrez ID: 113 HGNC ID: HGNC:238 Ensembl Gene: ENSG00000121281 OMIM ID: 600385

 

ADCY7 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05166HTLV-I infection

 

Expression of ADCY7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY7 113 203741_s_at 0.0249 0.9793
GSE20347 ADCY7 113 203741_s_at -0.7227 0.0137
GSE23400 ADCY7 113 203741_s_at 0.1645 0.1883
GSE26886 ADCY7 113 203741_s_at -1.6603 0.0010
GSE29001 ADCY7 113 203741_s_at -0.1120 0.7709
GSE38129 ADCY7 113 203741_s_at -0.3375 0.1542
GSE45670 ADCY7 113 203741_s_at 0.0088 0.9773
GSE63941 ADCY7 113 203741_s_at -0.6205 0.5145
GSE77861 ADCY7 113 203741_s_at -0.2227 0.7122
GSE97050 ADCY7 113 A_24_P416177 0.0204 0.9490
SRP007169 ADCY7 113 RNAseq -0.3168 0.4363
SRP008496 ADCY7 113 RNAseq -0.6185 0.0408
SRP064894 ADCY7 113 RNAseq -0.2113 0.5091
SRP133303 ADCY7 113 RNAseq -0.1801 0.3270
SRP159526 ADCY7 113 RNAseq -0.9242 0.0099
SRP193095 ADCY7 113 RNAseq -0.0139 0.9335
SRP219564 ADCY7 113 RNAseq 0.0195 0.9771
TCGA ADCY7 113 RNAseq 0.3179 0.0002

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ADCY7 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY7 113 3 1 26
GSE20123 ADCY7 113 3 1 26
GSE43470 ADCY7 113 2 7 34
GSE46452 ADCY7 113 38 1 20
GSE47630 ADCY7 113 11 7 22
GSE54993 ADCY7 113 2 5 63
GSE54994 ADCY7 113 6 10 37
GSE60625 ADCY7 113 4 0 7
GSE74703 ADCY7 113 2 4 30
GSE74704 ADCY7 113 3 1 16
TCGA ADCY7 113 25 12 59

Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.  

 

Somatic mutations of ADCY7:

 

Generating mutation plots.

 

Highly correlated genes for ADCY7:

 

Showing top 20/367 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY7LACTB0.820124303
ADCY7ELP40.778298303
ADCY7FRMD80.771094303
ADCY7STXBP50.751015303
ADCY7HUS10.750712303
ADCY7PPP4R20.743123303
ADCY7METTL150.738585404
ADCY7RAB3D0.737117303
ADCY7NAA200.736623303
ADCY7EAF10.734692404
ADCY7ZNF7100.729423303
ADCY7SLC25A430.726138404
ADCY7GTF3C60.7248303
ADCY7TMCC10.716704303
ADCY7PITPNA0.716581303
ADCY7HK20.714073303
ADCY7SLC46A20.713453303
ADCY7GRPEL20.710012303
ADCY7DHDDS0.70578303
ADCY7MTA30.701795404

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