| Full name: elongation factor for RNA polymerase II 2 | Alias Symbol: MRCCAT1 | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 22936 | HGNC ID: HGNC:17064 | Ensembl Gene: ENSG00000118985 | OMIM ID: 601874 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ELL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ELL2 | 22936 | 226099_at | -1.2882 | 0.1310 | |
| GSE20347 | ELL2 | 22936 | 214446_at | -1.3778 | 0.0000 | |
| GSE23400 | ELL2 | 22936 | 214446_at | -0.5825 | 0.0000 | |
| GSE26886 | ELL2 | 22936 | 226099_at | -1.9865 | 0.0001 | |
| GSE29001 | ELL2 | 22936 | 214446_at | -0.9170 | 0.0519 | |
| GSE38129 | ELL2 | 22936 | 214446_at | -0.9698 | 0.0018 | |
| GSE45670 | ELL2 | 22936 | 226099_at | -0.1185 | 0.6134 | |
| GSE53622 | ELL2 | 22936 | 65678 | -1.2834 | 0.0000 | |
| GSE53624 | ELL2 | 22936 | 65678 | -1.2729 | 0.0000 | |
| GSE63941 | ELL2 | 22936 | 226099_at | -2.4541 | 0.0138 | |
| GSE77861 | ELL2 | 22936 | 226099_at | -1.2652 | 0.0263 | |
| GSE97050 | ELL2 | 22936 | A_23_P58506 | -0.5394 | 0.1204 | |
| SRP007169 | ELL2 | 22936 | RNAseq | -2.3420 | 0.0000 | |
| SRP008496 | ELL2 | 22936 | RNAseq | -2.1387 | 0.0000 | |
| SRP064894 | ELL2 | 22936 | RNAseq | -1.1489 | 0.0000 | |
| SRP133303 | ELL2 | 22936 | RNAseq | -0.9017 | 0.0006 | |
| SRP159526 | ELL2 | 22936 | RNAseq | -1.7415 | 0.0001 | |
| SRP193095 | ELL2 | 22936 | RNAseq | -1.3473 | 0.0000 | |
| SRP219564 | ELL2 | 22936 | RNAseq | -0.9778 | 0.0164 | |
| TCGA | ELL2 | 22936 | RNAseq | -0.3406 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 11.
Survival by ELL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ELL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ELL2 | 22936 | 1 | 13 | 16 | |
| GSE20123 | ELL2 | 22936 | 1 | 13 | 16 | |
| GSE43470 | ELL2 | 22936 | 3 | 9 | 31 | |
| GSE46452 | ELL2 | 22936 | 0 | 28 | 31 | |
| GSE47630 | ELL2 | 22936 | 0 | 20 | 20 | |
| GSE54993 | ELL2 | 22936 | 8 | 1 | 61 | |
| GSE54994 | ELL2 | 22936 | 1 | 18 | 34 | |
| GSE60625 | ELL2 | 22936 | 0 | 0 | 11 | |
| GSE74703 | ELL2 | 22936 | 2 | 7 | 27 | |
| GSE74704 | ELL2 | 22936 | 1 | 7 | 12 | |
| TCGA | ELL2 | 22936 | 3 | 44 | 49 |
Total number of gains: 20; Total number of losses: 160; Total Number of normals: 308.
Somatic mutations of ELL2:
Generating mutation plots.
Highly correlated genes for ELL2:
Showing top 20/1332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ELL2 | CYSRT1 | 0.748821 | 6 | 0 | 6 |
| ELL2 | CCDC7 | 0.747086 | 3 | 0 | 3 |
| ELL2 | VSIG10L | 0.735292 | 6 | 0 | 6 |
| ELL2 | CXCR2 | 0.735029 | 11 | 0 | 11 |
| ELL2 | CWH43 | 0.730887 | 10 | 0 | 10 |
| ELL2 | CLEC3B | 0.72981 | 3 | 0 | 3 |
| ELL2 | FIBIN | 0.727666 | 3 | 0 | 3 |
| ELL2 | MXD1 | 0.726558 | 11 | 0 | 10 |
| ELL2 | GPBP1 | 0.72011 | 3 | 0 | 3 |
| ELL2 | MAP4K4 | 0.719113 | 3 | 0 | 3 |
| ELL2 | MTA3 | 0.718945 | 4 | 0 | 4 |
| ELL2 | BNIPL | 0.71829 | 6 | 0 | 5 |
| ELL2 | AK3 | 0.716605 | 6 | 0 | 6 |
| ELL2 | IL20RB | 0.715119 | 6 | 0 | 6 |
| ELL2 | TMOD3 | 0.712441 | 11 | 0 | 10 |
| ELL2 | FAM174A | 0.712006 | 9 | 0 | 7 |
| ELL2 | MRPS36 | 0.711034 | 7 | 0 | 6 |
| ELL2 | FNBP1 | 0.710691 | 3 | 0 | 3 |
| ELL2 | CLTB | 0.709469 | 11 | 0 | 10 |
| ELL2 | BTBD7 | 0.709113 | 5 | 0 | 4 |
For details and further investigation, click here
