| Full name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Alias Symbol: MTPB | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 3032 | HGNC ID: HGNC:4803 | Ensembl Gene: ENSG00000138029 | OMIM ID: 143450 |
| Drug and gene relationship at DGIdb | |||
Expression of HADHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HADHB | 3032 | 201007_at | -0.1207 | 0.7878 | |
| GSE20347 | HADHB | 3032 | 201007_at | -0.4249 | 0.0006 | |
| GSE23400 | HADHB | 3032 | 201007_at | -0.2993 | 0.0000 | |
| GSE26886 | HADHB | 3032 | 201007_at | -0.4737 | 0.0197 | |
| GSE29001 | HADHB | 3032 | 201007_at | -0.3834 | 0.0297 | |
| GSE38129 | HADHB | 3032 | 201007_at | -0.4400 | 0.0000 | |
| GSE45670 | HADHB | 3032 | 201007_at | -0.3675 | 0.0022 | |
| GSE53622 | HADHB | 3032 | 31061 | -1.2160 | 0.0000 | |
| GSE53624 | HADHB | 3032 | 31061 | -1.3001 | 0.0000 | |
| GSE63941 | HADHB | 3032 | 201007_at | -0.3793 | 0.3234 | |
| GSE77861 | HADHB | 3032 | 201007_at | -0.3439 | 0.0244 | |
| GSE97050 | HADHB | 3032 | A_23_P79703 | -0.5392 | 0.1205 | |
| SRP007169 | HADHB | 3032 | RNAseq | -1.2369 | 0.0001 | |
| SRP008496 | HADHB | 3032 | RNAseq | -0.9390 | 0.0000 | |
| SRP064894 | HADHB | 3032 | RNAseq | -0.5523 | 0.0000 | |
| SRP133303 | HADHB | 3032 | RNAseq | -0.4638 | 0.0126 | |
| SRP159526 | HADHB | 3032 | RNAseq | -0.4368 | 0.0455 | |
| SRP193095 | HADHB | 3032 | RNAseq | -0.6416 | 0.0000 | |
| SRP219564 | HADHB | 3032 | RNAseq | -0.7663 | 0.0424 | |
| TCGA | HADHB | 3032 | RNAseq | -0.1935 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by HADHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HADHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HADHB | 3032 | 11 | 2 | 17 | |
| GSE20123 | HADHB | 3032 | 11 | 2 | 17 | |
| GSE43470 | HADHB | 3032 | 3 | 1 | 39 | |
| GSE46452 | HADHB | 3032 | 3 | 4 | 52 | |
| GSE47630 | HADHB | 3032 | 8 | 0 | 32 | |
| GSE54993 | HADHB | 3032 | 0 | 6 | 64 | |
| GSE54994 | HADHB | 3032 | 10 | 0 | 43 | |
| GSE60625 | HADHB | 3032 | 0 | 3 | 8 | |
| GSE74703 | HADHB | 3032 | 3 | 0 | 33 | |
| GSE74704 | HADHB | 3032 | 9 | 1 | 10 | |
| TCGA | HADHB | 3032 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of HADHB:
Generating mutation plots.
Highly correlated genes for HADHB:
Showing top 20/1155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HADHB | CASC3 | 0.846303 | 3 | 0 | 3 |
| HADHB | CA13 | 0.78963 | 3 | 0 | 3 |
| HADHB | BBS9 | 0.782956 | 3 | 0 | 3 |
| HADHB | KRT78 | 0.772836 | 4 | 0 | 4 |
| HADHB | SLC10A5 | 0.772149 | 3 | 0 | 3 |
| HADHB | LACTBL1 | 0.760512 | 3 | 0 | 3 |
| HADHB | SNAPC3 | 0.755408 | 3 | 0 | 3 |
| HADHB | NFAT5 | 0.734756 | 4 | 0 | 4 |
| HADHB | PITHD1 | 0.728658 | 5 | 0 | 4 |
| HADHB | GRPEL2 | 0.726791 | 5 | 0 | 5 |
| HADHB | PRPF38A | 0.726498 | 3 | 0 | 3 |
| HADHB | C1GALT1C1 | 0.724716 | 3 | 0 | 3 |
| HADHB | PPCS | 0.714092 | 7 | 0 | 6 |
| HADHB | CGNL1 | 0.712802 | 5 | 0 | 4 |
| HADHB | ANGPTL1 | 0.71204 | 4 | 0 | 4 |
| HADHB | TMPRSS11B | 0.711478 | 4 | 0 | 4 |
| HADHB | SNCA | 0.709409 | 4 | 0 | 4 |
| HADHB | HADHA | 0.705736 | 12 | 0 | 11 |
| HADHB | ZACN | 0.702867 | 3 | 0 | 3 |
| HADHB | SLC46A2 | 0.695043 | 6 | 0 | 5 |
For details and further investigation, click here
