NFKBIA

 

Full name: NFKB inhibitor alpha Alias Symbol: IKBA|MAD-3|IkappaBalpha
Type: protein-coding gene Cytoband: 14q13.2
Entrez ID: 4792 HGNC ID: HGNC:7797 Ensembl Gene: ENSG00000100906 OMIM ID: 164008
Drug and gene relationship at DGIdb
Screen Evidence:

 

NFKBIA involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04931Insulin resistance
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05134Legionellosis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05162Measles
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer

 

Expression of NFKBIA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NFKBIA 4792 201502_s_at 0.5196 0.5071
GSE20347 NFKBIA 4792 201502_s_at 0.6635 0.0012
GSE23400 NFKBIA 4792 201502_s_at 0.2683 0.0269
GSE26886 NFKBIA 4792 201502_s_at 0.5017 0.1738
GSE29001 NFKBIA 4792 201502_s_at 0.3404 0.3887
GSE38129 NFKBIA 4792 201502_s_at 0.2247 0.3813
GSE45670 NFKBIA 4792 201502_s_at -0.1122 0.6326
GSE53622 NFKBIA 4792 443 0.1626 0.1499
GSE53624 NFKBIA 4792 443 -0.0955 0.2242
GSE63941 NFKBIA 4792 201502_s_at 1.8633 0.0332
GSE77861 NFKBIA 4792 201502_s_at 1.0889 0.0243
GSE97050 NFKBIA 4792 A_23_P106002 0.6571 0.1186
SRP007169 NFKBIA 4792 RNAseq -0.8102 0.2057
SRP008496 NFKBIA 4792 RNAseq -0.7869 0.0276
SRP064894 NFKBIA 4792 RNAseq -0.4186 0.0994
SRP133303 NFKBIA 4792 RNAseq 0.1958 0.3337
SRP159526 NFKBIA 4792 RNAseq 0.4968 0.1581
SRP193095 NFKBIA 4792 RNAseq 0.0867 0.7028
SRP219564 NFKBIA 4792 RNAseq 0.8094 0.0604
TCGA NFKBIA 4792 RNAseq 0.1630 0.0248

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by NFKBIA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NFKBIA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NFKBIA 4792 10 4 16
GSE20123 NFKBIA 4792 11 4 15
GSE43470 NFKBIA 4792 9 3 31
GSE46452 NFKBIA 4792 18 2 39
GSE47630 NFKBIA 4792 11 10 19
GSE54993 NFKBIA 4792 3 10 57
GSE54994 NFKBIA 4792 19 5 29
GSE60625 NFKBIA 4792 0 2 9
GSE74703 NFKBIA 4792 8 3 25
GSE74704 NFKBIA 4792 5 3 12
TCGA NFKBIA 4792 34 14 48

Total number of gains: 128; Total number of losses: 60; Total Number of normals: 300.  

 

Somatic mutations of NFKBIA:

 

Generating mutation plots.

 

Highly correlated genes for NFKBIA:

 

Showing top 20/167 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NFKBIAARL13B0.668926303
NFKBIAUBA60.664397303
NFKBIAHES60.659699303
NFKBIARAB3GAP10.656547303
NFKBIAHSPH10.646755303
NFKBIAB3GNT50.642218404
NFKBIAMIPOL10.635059403
NFKBIAFANCB0.633094303
NFKBIAGAL0.632855303
NFKBIABRMS1L0.631161504
NFKBIAPFN20.621852303
NFKBIALY960.621091303
NFKBIAAP1G20.617762303
NFKBIAOCIAD20.614299303
NFKBIAFXR10.608254403
NFKBIAEFNA10.606018505
NFKBIAKLHL240.604684606
NFKBIARSRC10.604139707
NFKBIANRARP0.603199504
NFKBIAPDHA10.599192303

For details and further investigation, click here