EFNA1

 

Full name: ephrin A1 Alias Symbol: LERK1|ECKLG
Type: protein-coding gene Cytoband: 1q22
Entrez ID: 1942 HGNC ID: HGNC:3221 Ensembl Gene: ENSG00000169242 OMIM ID: 191164
Drug and gene relationship at DGIdb

 

EFNA1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04360Axon guidance

 

Expression of EFNA1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EFNA1 1942 202023_at 0.3139 0.4977
GSE20347 EFNA1 1942 202023_at 0.9816 0.0000
GSE23400 EFNA1 1942 202023_at 1.1795 0.0000
GSE26886 EFNA1 1942 202023_at 2.0755 0.0000
GSE29001 EFNA1 1942 202023_at 1.0806 0.0019
GSE38129 EFNA1 1942 202023_at 1.2027 0.0000
GSE45670 EFNA1 1942 202023_at 0.9143 0.0000
GSE53622 EFNA1 1942 39532 1.1393 0.0000
GSE53624 EFNA1 1942 39532 1.0843 0.0000
GSE63941 EFNA1 1942 202023_at 4.1230 0.0020
GSE77861 EFNA1 1942 202023_at 1.4072 0.0029
GSE97050 EFNA1 1942 A_23_P113005 0.4352 0.1642
SRP007169 EFNA1 1942 RNAseq 0.9185 0.0533
SRP008496 EFNA1 1942 RNAseq 1.2902 0.0000
SRP064894 EFNA1 1942 RNAseq 0.8906 0.0009
SRP133303 EFNA1 1942 RNAseq 0.9035 0.0002
SRP159526 EFNA1 1942 RNAseq 1.4761 0.0009
SRP193095 EFNA1 1942 RNAseq 0.8355 0.0000
SRP219564 EFNA1 1942 RNAseq 1.0958 0.0403
TCGA EFNA1 1942 RNAseq 0.2893 0.0001

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by EFNA1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EFNA1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EFNA1 1942 14 0 16
GSE20123 EFNA1 1942 13 0 17
GSE43470 EFNA1 1942 6 2 35
GSE46452 EFNA1 1942 2 1 56
GSE47630 EFNA1 1942 14 0 26
GSE54993 EFNA1 1942 0 4 66
GSE54994 EFNA1 1942 16 0 37
GSE60625 EFNA1 1942 0 0 11
GSE74703 EFNA1 1942 6 1 29
GSE74704 EFNA1 1942 6 0 14
TCGA EFNA1 1942 38 2 56

Total number of gains: 115; Total number of losses: 10; Total Number of normals: 363.  

 

Somatic mutations of EFNA1:

 

Generating mutation plots.

 

Highly correlated genes for EFNA1:

 

Showing top 20/1602 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EFNA1SLC39A30.767863303
EFNA1WDR810.750274404
EFNA1KRTCAP20.741877403
EFNA1TRAPPC10.735081303
EFNA1MRPL380.733073303
EFNA1SLC44A10.732887606
EFNA1ZSCAN210.727539303
EFNA1SEMA4B0.72745404
EFNA1RPL120.726252303
EFNA1PRDM150.720653303
EFNA1UCK20.719077303
EFNA1FAM89A0.718179303
EFNA1FZD60.715204807
EFNA1KATNA10.705895303
EFNA1RTKN0.705371707
EFNA1ZBTB90.703467303
EFNA1CPT1A0.702264303
EFNA1ITPR30.70071109
EFNA1PPP5C0.700564303
EFNA1PSMG30.700296707

For details and further investigation, click here