| Full name: ubiquitin like modifier activating enzyme 6 | Alias Symbol: FLJ10808 | ||
| Type: protein-coding gene | Cytoband: 4q13.2 | ||
| Entrez ID: 55236 | HGNC ID: HGNC:25581 | Ensembl Gene: ENSG00000033178 | OMIM ID: 611361 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of UBA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBA6 | 55236 | 222602_at | 0.5976 | 0.3840 | |
| GSE20347 | UBA6 | 55236 | 218340_s_at | 0.1305 | 0.6985 | |
| GSE23400 | UBA6 | 55236 | 218340_s_at | 0.2074 | 0.1779 | |
| GSE26886 | UBA6 | 55236 | 222602_at | 0.5343 | 0.1589 | |
| GSE29001 | UBA6 | 55236 | 218340_s_at | 0.1407 | 0.7609 | |
| GSE38129 | UBA6 | 55236 | 218340_s_at | 0.5209 | 0.0607 | |
| GSE45670 | UBA6 | 55236 | 222602_at | 0.4733 | 0.0286 | |
| GSE53622 | UBA6 | 55236 | 95140 | 0.3508 | 0.0031 | |
| GSE53624 | UBA6 | 55236 | 95140 | 0.0057 | 0.9680 | |
| GSE63941 | UBA6 | 55236 | 222602_at | 0.2428 | 0.6131 | |
| GSE77861 | UBA6 | 55236 | 218340_s_at | 0.6927 | 0.2081 | |
| GSE97050 | UBA6 | 55236 | A_33_P3412035 | 0.5254 | 0.0866 | |
| SRP007169 | UBA6 | 55236 | RNAseq | -0.1323 | 0.7593 | |
| SRP008496 | UBA6 | 55236 | RNAseq | -0.3831 | 0.1927 | |
| SRP064894 | UBA6 | 55236 | RNAseq | -0.0762 | 0.7740 | |
| SRP133303 | UBA6 | 55236 | RNAseq | 0.8723 | 0.0071 | |
| SRP159526 | UBA6 | 55236 | RNAseq | -0.4059 | 0.0287 | |
| SRP193095 | UBA6 | 55236 | RNAseq | 0.0123 | 0.9377 | |
| SRP219564 | UBA6 | 55236 | RNAseq | -0.3323 | 0.5388 | |
| TCGA | UBA6 | 55236 | RNAseq | 0.2693 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBA6 | 55236 | 2 | 11 | 17 | |
| GSE20123 | UBA6 | 55236 | 2 | 12 | 16 | |
| GSE43470 | UBA6 | 55236 | 0 | 13 | 30 | |
| GSE46452 | UBA6 | 55236 | 2 | 35 | 22 | |
| GSE47630 | UBA6 | 55236 | 0 | 19 | 21 | |
| GSE54993 | UBA6 | 55236 | 7 | 0 | 63 | |
| GSE54994 | UBA6 | 55236 | 1 | 9 | 43 | |
| GSE60625 | UBA6 | 55236 | 0 | 0 | 11 | |
| GSE74703 | UBA6 | 55236 | 0 | 11 | 25 | |
| GSE74704 | UBA6 | 55236 | 1 | 8 | 11 | |
| TCGA | UBA6 | 55236 | 18 | 26 | 52 |
Total number of gains: 33; Total number of losses: 144; Total Number of normals: 311.
Somatic mutations of UBA6:
Generating mutation plots.
Highly correlated genes for UBA6:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBA6 | TRMT6 | 0.816699 | 3 | 0 | 3 |
| UBA6 | CDC27 | 0.807975 | 3 | 0 | 3 |
| UBA6 | VPS16 | 0.79985 | 3 | 0 | 3 |
| UBA6 | ARFGEF2 | 0.773341 | 3 | 0 | 3 |
| UBA6 | TRAF7 | 0.769663 | 3 | 0 | 3 |
| UBA6 | TMEM54 | 0.747811 | 3 | 0 | 3 |
| UBA6 | STEAP1B | 0.74543 | 3 | 0 | 3 |
| UBA6 | PPP6R3 | 0.739819 | 4 | 0 | 4 |
| UBA6 | B4GALT4 | 0.734499 | 3 | 0 | 3 |
| UBA6 | DNAJC7 | 0.727848 | 4 | 0 | 3 |
| UBA6 | MCM8 | 0.711887 | 3 | 0 | 3 |
| UBA6 | CARD10 | 0.711059 | 4 | 0 | 3 |
| UBA6 | KLHL24 | 0.709309 | 3 | 0 | 3 |
| UBA6 | SLC2A9 | 0.7041 | 3 | 0 | 3 |
| UBA6 | APOL6 | 0.697418 | 3 | 0 | 3 |
| UBA6 | MRPS28 | 0.694944 | 3 | 0 | 3 |
| UBA6 | CTDSPL2 | 0.689075 | 4 | 0 | 4 |
| UBA6 | DDX19A | 0.687139 | 3 | 0 | 3 |
| UBA6 | MAPK8 | 0.685635 | 3 | 0 | 3 |
| UBA6 | OSBPL2 | 0.684825 | 3 | 0 | 3 |
For details and further investigation, click here
