| Full name: lymphocyte antigen 96 | Alias Symbol: MD-2 | ||
| Type: protein-coding gene | Cytoband: 8q21.11 | ||
| Entrez ID: 23643 | HGNC ID: HGNC:17156 | Ensembl Gene: ENSG00000154589 | OMIM ID: 605243 |
| Drug and gene relationship at DGIdb | |||
LY96 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway | |
| hsa05145 | Toxoplasmosis |
Expression of LY96:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LY96 | 23643 | 206584_at | 1.0344 | 0.2154 | |
| GSE20347 | LY96 | 23643 | 206584_at | 2.0308 | 0.0000 | |
| GSE23400 | LY96 | 23643 | 206584_at | 1.0232 | 0.0000 | |
| GSE26886 | LY96 | 23643 | 206584_at | 0.9113 | 0.1082 | |
| GSE29001 | LY96 | 23643 | 206584_at | 1.4366 | 0.0139 | |
| GSE38129 | LY96 | 23643 | 206584_at | 1.5272 | 0.0001 | |
| GSE45670 | LY96 | 23643 | 206584_at | 0.8204 | 0.0656 | |
| GSE53622 | LY96 | 23643 | 41839 | 0.8879 | 0.0000 | |
| GSE53624 | LY96 | 23643 | 41839 | 1.0737 | 0.0000 | |
| GSE63941 | LY96 | 23643 | 206584_at | -4.2221 | 0.0243 | |
| GSE77861 | LY96 | 23643 | 206584_at | 1.5435 | 0.0973 | |
| GSE97050 | LY96 | 23643 | A_23_P94230 | 1.3706 | 0.0465 | |
| SRP007169 | LY96 | 23643 | RNAseq | 2.3730 | 0.0000 | |
| SRP008496 | LY96 | 23643 | RNAseq | 1.6650 | 0.0003 | |
| SRP064894 | LY96 | 23643 | RNAseq | 1.3651 | 0.0004 | |
| SRP133303 | LY96 | 23643 | RNAseq | 0.9471 | 0.0017 | |
| SRP159526 | LY96 | 23643 | RNAseq | 0.6449 | 0.3642 | |
| SRP193095 | LY96 | 23643 | RNAseq | 1.0722 | 0.0004 | |
| SRP219564 | LY96 | 23643 | RNAseq | 0.8279 | 0.2162 | |
| TCGA | LY96 | 23643 | RNAseq | 0.2621 | 0.1276 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by LY96 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LY96:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LY96 | 23643 | 15 | 0 | 15 | |
| GSE20123 | LY96 | 23643 | 16 | 0 | 14 | |
| GSE43470 | LY96 | 23643 | 18 | 1 | 24 | |
| GSE46452 | LY96 | 23643 | 21 | 1 | 37 | |
| GSE47630 | LY96 | 23643 | 23 | 0 | 17 | |
| GSE54993 | LY96 | 23643 | 0 | 19 | 51 | |
| GSE54994 | LY96 | 23643 | 30 | 0 | 23 | |
| GSE60625 | LY96 | 23643 | 0 | 4 | 7 | |
| GSE74703 | LY96 | 23643 | 15 | 1 | 20 | |
| GSE74704 | LY96 | 23643 | 11 | 0 | 9 | |
| TCGA | LY96 | 23643 | 50 | 2 | 44 |
Total number of gains: 199; Total number of losses: 28; Total Number of normals: 261.
Somatic mutations of LY96:
Generating mutation plots.
Highly correlated genes for LY96:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LY96 | FCGR3A | 0.766838 | 3 | 0 | 3 |
| LY96 | LRRC8C | 0.758524 | 3 | 0 | 3 |
| LY96 | SPI1 | 0.757384 | 4 | 0 | 3 |
| LY96 | CERKL | 0.75705 | 3 | 0 | 3 |
| LY96 | C19orf38 | 0.739107 | 3 | 0 | 3 |
| LY96 | CCDC127 | 0.729011 | 3 | 0 | 3 |
| LY96 | PREX1 | 0.727299 | 3 | 0 | 3 |
| LY96 | KTI12 | 0.723774 | 3 | 0 | 3 |
| LY96 | SPPL2A | 0.723438 | 3 | 0 | 3 |
| LY96 | TNFRSF8 | 0.720334 | 3 | 0 | 3 |
| LY96 | CMPK2 | 0.708084 | 4 | 0 | 4 |
| LY96 | HGF | 0.702186 | 4 | 0 | 4 |
| LY96 | PDIA5 | 0.70075 | 3 | 0 | 3 |
| LY96 | SLC26A11 | 0.70035 | 3 | 0 | 3 |
| LY96 | USF1 | 0.698371 | 4 | 0 | 4 |
| LY96 | AMMECR1L | 0.696493 | 3 | 0 | 3 |
| LY96 | PSMD13 | 0.695059 | 3 | 0 | 3 |
| LY96 | RASSF4 | 0.687104 | 4 | 0 | 3 |
| LY96 | PARVG | 0.686805 | 4 | 0 | 4 |
| LY96 | FMNL3 | 0.685642 | 5 | 0 | 4 |
For details and further investigation, click here
