PFN2

 

Full name: profilin 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 3q25.1
Entrez ID: 5217 HGNC ID: HGNC:8882 Ensembl Gene: ENSG00000070087 OMIM ID: 176590
Drug and gene relationship at DGIdb

 

PFN2 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection

 

Expression of PFN2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PFN2 5217 204992_s_at 1.6295 0.1130
GSE20347 PFN2 5217 204992_s_at 2.3188 0.0000
GSE23400 PFN2 5217 204992_s_at 1.5594 0.0000
GSE26886 PFN2 5217 204992_s_at 1.7859 0.0000
GSE29001 PFN2 5217 204992_s_at 1.4233 0.0005
GSE38129 PFN2 5217 204992_s_at 1.9613 0.0000
GSE45670 PFN2 5217 204992_s_at 1.5644 0.0022
GSE53622 PFN2 5217 22977 2.3676 0.0000
GSE53624 PFN2 5217 22977 2.3126 0.0000
GSE63941 PFN2 5217 204992_s_at 0.4950 0.4042
GSE77861 PFN2 5217 204992_s_at 2.7952 0.0003
GSE97050 PFN2 5217 A_23_P253301 0.9398 0.0832
SRP007169 PFN2 5217 RNAseq 2.5835 0.0000
SRP008496 PFN2 5217 RNAseq 3.3516 0.0000
SRP064894 PFN2 5217 RNAseq 1.7394 0.0000
SRP133303 PFN2 5217 RNAseq 2.5917 0.0000
SRP159526 PFN2 5217 RNAseq 3.1492 0.0000
SRP193095 PFN2 5217 RNAseq 2.5450 0.0000
TCGA PFN2 5217 RNAseq 0.4891 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by PFN2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PFN2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PFN2 5217 22 0 8
GSE20123 PFN2 5217 22 0 8
GSE43470 PFN2 5217 23 0 20
GSE46452 PFN2 5217 18 2 39
GSE47630 PFN2 5217 19 3 18
GSE54993 PFN2 5217 1 10 59
GSE54994 PFN2 5217 37 1 15
GSE60625 PFN2 5217 0 6 5
GSE74703 PFN2 5217 20 0 16
GSE74704 PFN2 5217 15 0 5
TCGA PFN2 5217 72 1 23

Total number of gains: 249; Total number of losses: 23; Total Number of normals: 216.  

 

Somatic mutations of PFN2:

 

Generating mutation plots.

 

Highly correlated genes for PFN2:

 

Showing top 20/2056 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PFN2WDR540.774099707
PFN2PYCR20.772581303
PFN2SLC36A40.770143303
PFN2SP40.769744303
PFN2LPCAT10.7655311011
PFN2LILRB20.759702303
PFN2FMNL20.759541707
PFN2FNDC3B0.75408811011
PFN2COL4A10.75132511011
PFN2FAM89A0.74699303
PFN2TMEM1380.746845606
PFN2SCNM10.741727303
PFN2STK30.74122511011
PFN2ZNF7070.740903303
PFN2CMSS10.740832605
PFN2POLRMT0.739163303
PFN2CD2760.737513404
PFN2VAX10.736059303
PFN2SERPINH10.73497210010
PFN2ATP6V1C10.73491610010

For details and further investigation, click here