| Full name: somatostatin receptor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 6752 | HGNC ID: HGNC:11331 | Ensembl Gene: ENSG00000180616 | OMIM ID: 182452 |
| Drug and gene relationship at DGIdb | |||
SSTR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04971 | Gastric acid secretion |
Expression of SSTR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SSTR2 | 6752 | 239031_at | -0.1475 | 0.4646 | |
| GSE20347 | SSTR2 | 6752 | 217455_s_at | -0.0782 | 0.3364 | |
| GSE23400 | SSTR2 | 6752 | 217455_s_at | -0.1440 | 0.0001 | |
| GSE26886 | SSTR2 | 6752 | 217455_s_at | -0.0761 | 0.4696 | |
| GSE29001 | SSTR2 | 6752 | 217455_s_at | -0.1471 | 0.3838 | |
| GSE38129 | SSTR2 | 6752 | 217455_s_at | -0.1690 | 0.0196 | |
| GSE45670 | SSTR2 | 6752 | 239031_at | 0.1440 | 0.7234 | |
| GSE53622 | SSTR2 | 6752 | 6384 | 0.5224 | 0.0000 | |
| GSE53624 | SSTR2 | 6752 | 6384 | 0.4326 | 0.0001 | |
| GSE63941 | SSTR2 | 6752 | 217455_s_at | 0.1406 | 0.5831 | |
| GSE77861 | SSTR2 | 6752 | 239031_at | -0.1159 | 0.3724 | |
| GSE97050 | SSTR2 | 6752 | A_33_P3352467 | 0.2863 | 0.2682 | |
| SRP007169 | SSTR2 | 6752 | RNAseq | 0.3450 | 0.5065 | |
| SRP064894 | SSTR2 | 6752 | RNAseq | 0.1923 | 0.4589 | |
| SRP133303 | SSTR2 | 6752 | RNAseq | 0.1636 | 0.1304 | |
| SRP159526 | SSTR2 | 6752 | RNAseq | 0.0892 | 0.7945 | |
| SRP193095 | SSTR2 | 6752 | RNAseq | 0.1821 | 0.2112 | |
| SRP219564 | SSTR2 | 6752 | RNAseq | -0.1364 | 0.7831 | |
| TCGA | SSTR2 | 6752 | RNAseq | -1.0525 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SSTR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SSTR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SSTR2 | 6752 | 3 | 2 | 25 | |
| GSE20123 | SSTR2 | 6752 | 3 | 2 | 25 | |
| GSE43470 | SSTR2 | 6752 | 6 | 3 | 34 | |
| GSE46452 | SSTR2 | 6752 | 33 | 0 | 26 | |
| GSE47630 | SSTR2 | 6752 | 8 | 1 | 31 | |
| GSE54993 | SSTR2 | 6752 | 2 | 5 | 63 | |
| GSE54994 | SSTR2 | 6752 | 10 | 4 | 39 | |
| GSE60625 | SSTR2 | 6752 | 6 | 0 | 5 | |
| GSE74703 | SSTR2 | 6752 | 6 | 1 | 29 | |
| GSE74704 | SSTR2 | 6752 | 3 | 2 | 15 | |
| TCGA | SSTR2 | 6752 | 32 | 10 | 54 |
Total number of gains: 112; Total number of losses: 30; Total Number of normals: 346.
Somatic mutations of SSTR2:
Generating mutation plots.
Highly correlated genes for SSTR2:
Showing top 20/469 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SSTR2 | KLF17 | 0.779473 | 3 | 0 | 3 |
| SSTR2 | SRCIN1 | 0.743901 | 3 | 0 | 3 |
| SSTR2 | RIN1 | 0.73777 | 3 | 0 | 3 |
| SSTR2 | TRPM8 | 0.729459 | 3 | 0 | 3 |
| SSTR2 | CNPY1 | 0.727365 | 4 | 0 | 4 |
| SSTR2 | ZGLP1 | 0.725025 | 4 | 0 | 3 |
| SSTR2 | SALL3 | 0.722122 | 3 | 0 | 3 |
| SSTR2 | INHBC | 0.720379 | 3 | 0 | 3 |
| SSTR2 | BRSK1 | 0.714794 | 3 | 0 | 3 |
| SSTR2 | TERT | 0.709428 | 6 | 0 | 6 |
| SSTR2 | SHISA8 | 0.705788 | 3 | 0 | 3 |
| SSTR2 | JSRP1 | 0.698187 | 3 | 0 | 3 |
| SSTR2 | EYS | 0.695625 | 4 | 0 | 4 |
| SSTR2 | PLA2G2D | 0.694913 | 5 | 0 | 4 |
| SSTR2 | USH1C | 0.693802 | 5 | 0 | 4 |
| SSTR2 | ABCA4 | 0.688828 | 3 | 0 | 3 |
| SSTR2 | CCL13 | 0.687928 | 3 | 0 | 3 |
| SSTR2 | TRPA1 | 0.687061 | 3 | 0 | 3 |
| SSTR2 | PGC | 0.686803 | 4 | 0 | 3 |
| SSTR2 | GGTLC1 | 0.684526 | 3 | 0 | 3 |
For details and further investigation, click here
