| Full name: paired box 4 | Alias Symbol: MODY9 | ||
| Type: protein-coding gene | Cytoband: 7q32.1 | ||
| Entrez ID: 5078 | HGNC ID: HGNC:8618 | Ensembl Gene: ENSG00000106331 | OMIM ID: 167413 |
| Drug and gene relationship at DGIdb | |||
PAX4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of PAX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAX4 | 5078 | 211176_s_at | -0.0727 | 0.7661 | |
| GSE20347 | PAX4 | 5078 | 211176_s_at | -0.0681 | 0.4211 | |
| GSE23400 | PAX4 | 5078 | 211176_s_at | -0.0696 | 0.1462 | |
| GSE26886 | PAX4 | 5078 | 211176_s_at | 0.1556 | 0.2956 | |
| GSE29001 | PAX4 | 5078 | 211176_s_at | -0.2059 | 0.1089 | |
| GSE38129 | PAX4 | 5078 | 211176_s_at | -0.0929 | 0.2794 | |
| GSE45670 | PAX4 | 5078 | 211176_s_at | -0.0881 | 0.3910 | |
| GSE53622 | PAX4 | 5078 | 75592 | 0.0461 | 0.6086 | |
| GSE53624 | PAX4 | 5078 | 75592 | 0.3436 | 0.0068 | |
| GSE63941 | PAX4 | 5078 | 211176_s_at | 0.1452 | 0.3910 | |
| GSE77861 | PAX4 | 5078 | 211176_s_at | -0.2907 | 0.0358 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PAX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAX4 | 5078 | 7 | 1 | 22 | |
| GSE20123 | PAX4 | 5078 | 7 | 2 | 21 | |
| GSE43470 | PAX4 | 5078 | 2 | 3 | 38 | |
| GSE46452 | PAX4 | 5078 | 7 | 2 | 50 | |
| GSE47630 | PAX4 | 5078 | 7 | 4 | 29 | |
| GSE54993 | PAX4 | 5078 | 3 | 5 | 62 | |
| GSE54994 | PAX4 | 5078 | 9 | 7 | 37 | |
| GSE60625 | PAX4 | 5078 | 0 | 0 | 11 | |
| GSE74703 | PAX4 | 5078 | 2 | 3 | 31 | |
| GSE74704 | PAX4 | 5078 | 3 | 2 | 15 | |
| TCGA | PAX4 | 5078 | 27 | 22 | 47 |
Total number of gains: 74; Total number of losses: 51; Total Number of normals: 363.
Somatic mutations of PAX4:
Generating mutation plots.
Highly correlated genes for PAX4:
Showing top 20/952 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAX4 | NKD1 | 0.693578 | 3 | 0 | 3 |
| PAX4 | KCNT1 | 0.685995 | 3 | 0 | 3 |
| PAX4 | ITGB3 | 0.676959 | 4 | 0 | 4 |
| PAX4 | CPA2 | 0.673222 | 3 | 0 | 3 |
| PAX4 | THRB | 0.667028 | 3 | 0 | 3 |
| PAX4 | VWA7 | 0.666811 | 8 | 0 | 7 |
| PAX4 | FAM171A2 | 0.666773 | 4 | 0 | 4 |
| PAX4 | COL26A1 | 0.666528 | 4 | 0 | 4 |
| PAX4 | PERM1 | 0.664708 | 3 | 0 | 3 |
| PAX4 | LINC00486 | 0.664045 | 4 | 0 | 4 |
| PAX4 | PGM5 | 0.663275 | 4 | 0 | 4 |
| PAX4 | CRHR2 | 0.656622 | 5 | 0 | 5 |
| PAX4 | GLI4 | 0.653839 | 4 | 0 | 3 |
| PAX4 | CISH | 0.653265 | 5 | 0 | 5 |
| PAX4 | KIAA1614 | 0.653124 | 8 | 0 | 7 |
| PAX4 | IL9R | 0.651146 | 4 | 0 | 4 |
| PAX4 | GABRR2 | 0.64782 | 5 | 0 | 4 |
| PAX4 | BTN1A1 | 0.64529 | 4 | 0 | 4 |
| PAX4 | KRTAP5-8 | 0.643723 | 6 | 0 | 5 |
| PAX4 | DEFB108B | 0.643317 | 4 | 0 | 3 |
For details and further investigation, click here
