| Full name: ROS proto-oncogene 1, receptor tyrosine kinase | Alias Symbol: MCF3|ROS|c-ros-1 | ||
| Type: protein-coding gene | Cytoband: 6q22.1 | ||
| Entrez ID: 6098 | HGNC ID: HGNC:10261 | Ensembl Gene: ENSG00000047936 | OMIM ID: 165020 |
| Drug and gene relationship at DGIdb | |||
Expression of ROS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ROS1 | 6098 | 244363_at | 0.0501 | 0.8518 | |
| GSE20347 | ROS1 | 6098 | 207569_at | 0.0772 | 0.2823 | |
| GSE23400 | ROS1 | 6098 | 207569_at | -0.0289 | 0.5482 | |
| GSE26886 | ROS1 | 6098 | 207569_at | 0.0139 | 0.9243 | |
| GSE29001 | ROS1 | 6098 | 207569_at | -0.0108 | 0.9404 | |
| GSE38129 | ROS1 | 6098 | 207569_at | 0.0848 | 0.2334 | |
| GSE45670 | ROS1 | 6098 | 207569_at | 0.0260 | 0.8684 | |
| GSE53622 | ROS1 | 6098 | 86779 | 0.5180 | 0.0004 | |
| GSE53624 | ROS1 | 6098 | 86779 | 0.7683 | 0.0000 | |
| GSE63941 | ROS1 | 6098 | 207569_at | 0.1261 | 0.7068 | |
| GSE77861 | ROS1 | 6098 | 207569_at | -0.1082 | 0.4200 | |
| GSE97050 | ROS1 | 6098 | A_23_P70278 | 0.0656 | 0.7383 | |
| SRP133303 | ROS1 | 6098 | RNAseq | 6.3102 | 0.0000 | |
| SRP159526 | ROS1 | 6098 | RNAseq | 8.4244 | 0.0000 | |
| TCGA | ROS1 | 6098 | RNAseq | 2.8411 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ROS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ROS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ROS1 | 6098 | 1 | 4 | 25 | |
| GSE20123 | ROS1 | 6098 | 1 | 3 | 26 | |
| GSE43470 | ROS1 | 6098 | 3 | 1 | 39 | |
| GSE46452 | ROS1 | 6098 | 2 | 11 | 46 | |
| GSE47630 | ROS1 | 6098 | 9 | 4 | 27 | |
| GSE54993 | ROS1 | 6098 | 3 | 2 | 65 | |
| GSE54994 | ROS1 | 6098 | 8 | 8 | 37 | |
| GSE60625 | ROS1 | 6098 | 0 | 1 | 10 | |
| GSE74703 | ROS1 | 6098 | 2 | 1 | 33 | |
| GSE74704 | ROS1 | 6098 | 0 | 1 | 19 | |
| TCGA | ROS1 | 6098 | 8 | 22 | 66 |
Total number of gains: 37; Total number of losses: 58; Total Number of normals: 393.
Somatic mutations of ROS1:
Generating mutation plots.
Highly correlated genes for ROS1:
Showing top 20/258 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ROS1 | MEP1B | 0.743472 | 3 | 0 | 3 |
| ROS1 | GPHA2 | 0.731484 | 3 | 0 | 3 |
| ROS1 | LRRC72 | 0.727388 | 3 | 0 | 3 |
| ROS1 | SV2C | 0.721053 | 4 | 0 | 4 |
| ROS1 | NXNL1 | 0.718956 | 3 | 0 | 3 |
| ROS1 | SCGN | 0.717429 | 4 | 0 | 4 |
| ROS1 | AQP8 | 0.709265 | 3 | 0 | 3 |
| ROS1 | USH1C | 0.692773 | 3 | 0 | 3 |
| ROS1 | ZNF444 | 0.690974 | 3 | 0 | 3 |
| ROS1 | PGC | 0.690008 | 3 | 0 | 3 |
| ROS1 | PRG3 | 0.689851 | 3 | 0 | 3 |
| ROS1 | ESPNL | 0.688458 | 4 | 0 | 4 |
| ROS1 | PRKAR1B | 0.68697 | 3 | 0 | 3 |
| ROS1 | PPP2R2B | 0.679867 | 3 | 0 | 3 |
| ROS1 | LINC01432 | 0.677267 | 3 | 0 | 3 |
| ROS1 | TEF | 0.675365 | 3 | 0 | 3 |
| ROS1 | LIM2 | 0.67324 | 3 | 0 | 3 |
| ROS1 | NOBOX | 0.67215 | 4 | 0 | 4 |
| ROS1 | KIRREL2 | 0.671779 | 3 | 0 | 3 |
| ROS1 | FGF17 | 0.671137 | 4 | 0 | 3 |
For details and further investigation, click here
