| Full name: RUN and SH3 domain containing 2 | Alias Symbol: KIAA0375 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 9853 | HGNC ID: HGNC:23625 | Ensembl Gene: ENSG00000198853 | OMIM ID: 611053 |
| Drug and gene relationship at DGIdb | |||
Expression of RUSC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RUSC2 | 9853 | 213066_at | -0.4762 | 0.1829 | |
| GSE20347 | RUSC2 | 9853 | 213066_at | -0.2068 | 0.0371 | |
| GSE23400 | RUSC2 | 9853 | 213066_at | -0.3487 | 0.0000 | |
| GSE26886 | RUSC2 | 9853 | 213066_at | -0.3335 | 0.2074 | |
| GSE29001 | RUSC2 | 9853 | 213066_at | -0.4873 | 0.0122 | |
| GSE38129 | RUSC2 | 9853 | 213066_at | -0.4802 | 0.0000 | |
| GSE45670 | RUSC2 | 9853 | 213066_at | -0.4700 | 0.0014 | |
| GSE53622 | RUSC2 | 9853 | 26407 | -1.2084 | 0.0000 | |
| GSE53624 | RUSC2 | 9853 | 26407 | -1.2282 | 0.0000 | |
| GSE63941 | RUSC2 | 9853 | 213066_at | -1.1226 | 0.0055 | |
| GSE77861 | RUSC2 | 9853 | 213066_at | -0.3393 | 0.0376 | |
| GSE97050 | RUSC2 | 9853 | A_23_P216549 | -0.5825 | 0.1533 | |
| SRP007169 | RUSC2 | 9853 | RNAseq | -3.3345 | 0.0000 | |
| SRP008496 | RUSC2 | 9853 | RNAseq | -2.2849 | 0.0000 | |
| SRP064894 | RUSC2 | 9853 | RNAseq | -1.0652 | 0.0000 | |
| SRP133303 | RUSC2 | 9853 | RNAseq | -1.0175 | 0.0005 | |
| SRP159526 | RUSC2 | 9853 | RNAseq | -1.1215 | 0.0010 | |
| SRP193095 | RUSC2 | 9853 | RNAseq | -1.4267 | 0.0000 | |
| SRP219564 | RUSC2 | 9853 | RNAseq | -0.5319 | 0.2746 | |
| TCGA | RUSC2 | 9853 | RNAseq | -0.3612 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by RUSC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RUSC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RUSC2 | 9853 | 3 | 12 | 15 | |
| GSE20123 | RUSC2 | 9853 | 3 | 12 | 15 | |
| GSE43470 | RUSC2 | 9853 | 3 | 10 | 30 | |
| GSE46452 | RUSC2 | 9853 | 6 | 15 | 38 | |
| GSE47630 | RUSC2 | 9853 | 1 | 20 | 19 | |
| GSE54993 | RUSC2 | 9853 | 6 | 0 | 64 | |
| GSE54994 | RUSC2 | 9853 | 6 | 12 | 35 | |
| GSE60625 | RUSC2 | 9853 | 0 | 0 | 11 | |
| GSE74703 | RUSC2 | 9853 | 2 | 7 | 27 | |
| GSE74704 | RUSC2 | 9853 | 0 | 10 | 10 | |
| TCGA | RUSC2 | 9853 | 17 | 44 | 35 |
Total number of gains: 47; Total number of losses: 142; Total Number of normals: 299.
Somatic mutations of RUSC2:
Generating mutation plots.
Highly correlated genes for RUSC2:
Showing top 20/1011 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RUSC2 | MYZAP | 0.75561 | 3 | 0 | 3 |
| RUSC2 | NEXN | 0.739281 | 5 | 0 | 5 |
| RUSC2 | PIH1D2 | 0.727233 | 3 | 0 | 3 |
| RUSC2 | NKD1 | 0.725996 | 3 | 0 | 3 |
| RUSC2 | ARHGAP10 | 0.721226 | 12 | 0 | 11 |
| RUSC2 | PGM5-AS1 | 0.711786 | 3 | 0 | 3 |
| RUSC2 | TCP11L2 | 0.702523 | 3 | 0 | 3 |
| RUSC2 | ANKRD37 | 0.695105 | 3 | 0 | 3 |
| RUSC2 | DACT3 | 0.693868 | 6 | 0 | 6 |
| RUSC2 | CACNA1H | 0.693644 | 6 | 0 | 6 |
| RUSC2 | RBFOX3 | 0.691216 | 3 | 0 | 3 |
| RUSC2 | ARMC2 | 0.69115 | 3 | 0 | 3 |
| RUSC2 | ZNRF1 | 0.689659 | 3 | 0 | 3 |
| RUSC2 | GIPC3 | 0.689397 | 3 | 0 | 3 |
| RUSC2 | NEGR1 | 0.688637 | 6 | 0 | 6 |
| RUSC2 | SHROOM3 | 0.678611 | 6 | 0 | 6 |
| RUSC2 | C1QTNF2 | 0.678513 | 4 | 0 | 3 |
| RUSC2 | MYO15A | 0.673342 | 4 | 0 | 3 |
| RUSC2 | LRRC29 | 0.672357 | 3 | 0 | 3 |
| RUSC2 | FENDRR | 0.670739 | 5 | 0 | 5 |
For details and further investigation, click here
