MYCN

 

Full name: MYCN proto-oncogene, bHLH transcription factor Alias Symbol: bHLHe37|N-myc|MYCNOT
Type: protein-coding gene Cytoband: 2p24.3
Entrez ID: 4613 HGNC ID: HGNC:7559 Ensembl Gene: ENSG00000134323 OMIM ID: 164840
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 14/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MYCN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MYCN 4613 209757_s_at -0.3820 0.2321
GSE20347 MYCN 4613 209757_s_at 0.2640 0.4840
GSE23400 MYCN 4613 211377_x_at -0.1681 0.0000
GSE26886 MYCN 4613 209757_s_at -0.1852 0.6147
GSE29001 MYCN 4613 209757_s_at 0.0645 0.9186
GSE38129 MYCN 4613 209757_s_at 0.2525 0.3949
GSE45670 MYCN 4613 211377_x_at -0.0716 0.5155
GSE53622 MYCN 4613 121074 0.2081 0.5158
GSE53624 MYCN 4613 121074 -0.3732 0.1229
GSE63941 MYCN 4613 209756_s_at 0.2754 0.1588
GSE77861 MYCN 4613 211377_x_at -0.1159 0.2290
GSE97050 MYCN 4613 A_24_P94402 0.0829 0.8427
SRP133303 MYCN 4613 RNAseq -0.4683 0.2613
TCGA MYCN 4613 RNAseq -0.3247 0.4371

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MYCN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MYCN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MYCN 4613 9 2 19
GSE20123 MYCN 4613 9 2 19
GSE43470 MYCN 4613 2 0 41
GSE46452 MYCN 4613 3 4 52
GSE47630 MYCN 4613 7 0 33
GSE54993 MYCN 4613 0 7 63
GSE54994 MYCN 4613 10 0 43
GSE60625 MYCN 4613 0 3 8
GSE74703 MYCN 4613 2 0 34
GSE74704 MYCN 4613 8 2 10
TCGA MYCN 4613 35 3 58

Total number of gains: 85; Total number of losses: 23; Total Number of normals: 380.  

 

Somatic mutations of MYCN:

 

Generating mutation plots.

 

Highly correlated genes for MYCN:

 

Showing top 20/461 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MYCNPPP1R9A0.781795303
MYCNPLA2G2A0.773278303
MYCNZNF3580.76061303
MYCNZNF2070.76002303
MYCNGPR310.748249303
MYCNDOK10.747214303
MYCNATP6AP10.73692303
MYCNAP3M10.736584303
MYCNC2orf160.735963303
MYCNSPRY10.734614303
MYCNNOXO10.733212303
MYCNTSHZ20.732746303
MYCNGNG20.727131303
MYCNSAMD150.726906303
MYCNFIS10.724186303
MYCNCLN60.720933303
MYCNPDE6A0.715206404
MYCNGPR37L10.707158303
MYCNCCL240.704531303
MYCNLPAR10.701433303

For details and further investigation, click here