| Full name: NKD inhibitor of WNT signaling pathway 2 | Alias Symbol: Naked2 | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 85409 | HGNC ID: HGNC:17046 | Ensembl Gene: ENSG00000145506 | OMIM ID: 607852 |
| Drug and gene relationship at DGIdb | |||
NKD2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of NKD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NKD2 | 85409 | 232201_at | 0.0647 | 0.9272 | |
| GSE26886 | NKD2 | 85409 | 232201_at | 0.5934 | 0.0005 | |
| GSE45670 | NKD2 | 85409 | 232201_at | 0.2774 | 0.1513 | |
| GSE53622 | NKD2 | 85409 | 48197 | 0.9599 | 0.0000 | |
| GSE53624 | NKD2 | 85409 | 48197 | 1.2266 | 0.0000 | |
| GSE63941 | NKD2 | 85409 | 232201_at | -0.9182 | 0.0021 | |
| GSE77861 | NKD2 | 85409 | 232201_at | 0.4587 | 0.0554 | |
| GSE97050 | NKD2 | 85409 | A_33_P3252954 | -0.2692 | 0.2966 | |
| SRP007169 | NKD2 | 85409 | RNAseq | 2.3016 | 0.0000 | |
| SRP008496 | NKD2 | 85409 | RNAseq | 2.5208 | 0.0000 | |
| SRP064894 | NKD2 | 85409 | RNAseq | 0.2333 | 0.5304 | |
| SRP133303 | NKD2 | 85409 | RNAseq | 0.2972 | 0.2482 | |
| SRP159526 | NKD2 | 85409 | RNAseq | 1.8370 | 0.0001 | |
| SRP219564 | NKD2 | 85409 | RNAseq | 0.8673 | 0.0255 | |
| TCGA | NKD2 | 85409 | RNAseq | 1.0713 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by NKD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NKD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NKD2 | 85409 | 13 | 1 | 16 | |
| GSE20123 | NKD2 | 85409 | 13 | 1 | 16 | |
| GSE43470 | NKD2 | 85409 | 17 | 1 | 25 | |
| GSE46452 | NKD2 | 85409 | 6 | 22 | 31 | |
| GSE47630 | NKD2 | 85409 | 7 | 11 | 22 | |
| GSE54993 | NKD2 | 85409 | 5 | 5 | 60 | |
| GSE54994 | NKD2 | 85409 | 29 | 1 | 23 | |
| GSE60625 | NKD2 | 85409 | 0 | 0 | 11 | |
| GSE74703 | NKD2 | 85409 | 14 | 0 | 22 | |
| GSE74704 | NKD2 | 85409 | 11 | 0 | 9 | |
| TCGA | NKD2 | 85409 | 61 | 3 | 32 |
Total number of gains: 176; Total number of losses: 45; Total Number of normals: 267.
Somatic mutations of NKD2:
Generating mutation plots.
Highly correlated genes for NKD2:
Showing top 20/76 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NKD2 | FFAR1 | 0.760563 | 3 | 0 | 3 |
| NKD2 | GJD4 | 0.730617 | 3 | 0 | 3 |
| NKD2 | JSRP1 | 0.708101 | 3 | 0 | 3 |
| NKD2 | PSTPIP1 | 0.686281 | 3 | 0 | 3 |
| NKD2 | HSD17B14 | 0.680403 | 3 | 0 | 3 |
| NKD2 | MEPE | 0.67553 | 3 | 0 | 3 |
| NKD2 | ASPHD1 | 0.670113 | 3 | 0 | 3 |
| NKD2 | BATF | 0.668745 | 3 | 0 | 3 |
| NKD2 | TBX2 | 0.664383 | 5 | 0 | 4 |
| NKD2 | ARID3A | 0.661356 | 4 | 0 | 4 |
| NKD2 | NPW | 0.651801 | 4 | 0 | 3 |
| NKD2 | DAB1 | 0.641143 | 3 | 0 | 3 |
| NKD2 | TMEM151B | 0.638124 | 4 | 0 | 3 |
| NKD2 | SNAI2 | 0.637721 | 3 | 0 | 3 |
| NKD2 | TNNI1 | 0.633524 | 3 | 0 | 3 |
| NKD2 | ST20 | 0.627421 | 4 | 0 | 3 |
| NKD2 | GGTLC1 | 0.623211 | 3 | 0 | 3 |
| NKD2 | ADAMTS2 | 0.622795 | 6 | 0 | 5 |
| NKD2 | YPEL4 | 0.6185 | 4 | 0 | 3 |
| NKD2 | KAZALD1 | 0.60982 | 5 | 0 | 5 |
For details and further investigation, click here
