| Full name: T-box transcription factor 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q23.2 | ||
| Entrez ID: 6909 | HGNC ID: HGNC:11597 | Ensembl Gene: ENSG00000121068 | OMIM ID: 600747 |
| Drug and gene relationship at DGIdb | |||
Expression of TBX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBX2 | 6909 | 40560_at | -0.0316 | 0.9434 | |
| GSE20347 | TBX2 | 6909 | 40560_at | 0.5326 | 0.0808 | |
| GSE23400 | TBX2 | 6909 | 40560_at | -0.0859 | 0.0122 | |
| GSE26886 | TBX2 | 6909 | 205993_s_at | 0.4659 | 0.0004 | |
| GSE29001 | TBX2 | 6909 | 40560_at | 0.1890 | 0.6040 | |
| GSE38129 | TBX2 | 6909 | 40560_at | 0.1632 | 0.5109 | |
| GSE45670 | TBX2 | 6909 | 40560_at | -0.2823 | 0.3521 | |
| GSE53622 | TBX2 | 6909 | 55389 | 0.2153 | 0.0236 | |
| GSE53624 | TBX2 | 6909 | 55389 | 0.3984 | 0.0001 | |
| GSE63941 | TBX2 | 6909 | 40560_at | -4.3043 | 0.0000 | |
| GSE77861 | TBX2 | 6909 | 213417_at | 0.5159 | 0.0699 | |
| GSE97050 | TBX2 | 6909 | A_23_P164451 | 0.0338 | 0.8905 | |
| SRP064894 | TBX2 | 6909 | RNAseq | 0.3584 | 0.2270 | |
| SRP133303 | TBX2 | 6909 | RNAseq | 0.0585 | 0.8712 | |
| SRP159526 | TBX2 | 6909 | RNAseq | 0.5226 | 0.1390 | |
| SRP193095 | TBX2 | 6909 | RNAseq | 1.7229 | 0.0000 | |
| SRP219564 | TBX2 | 6909 | RNAseq | -0.4956 | 0.2121 | |
| TCGA | TBX2 | 6909 | RNAseq | -0.1468 | 0.1821 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by TBX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBX2 | 6909 | 4 | 1 | 25 | |
| GSE20123 | TBX2 | 6909 | 4 | 1 | 25 | |
| GSE43470 | TBX2 | 6909 | 5 | 0 | 38 | |
| GSE46452 | TBX2 | 6909 | 32 | 0 | 27 | |
| GSE47630 | TBX2 | 6909 | 7 | 1 | 32 | |
| GSE54993 | TBX2 | 6909 | 2 | 5 | 63 | |
| GSE54994 | TBX2 | 6909 | 9 | 5 | 39 | |
| GSE60625 | TBX2 | 6909 | 4 | 0 | 7 | |
| GSE74703 | TBX2 | 6909 | 5 | 0 | 31 | |
| GSE74704 | TBX2 | 6909 | 3 | 1 | 16 | |
| TCGA | TBX2 | 6909 | 31 | 6 | 59 |
Total number of gains: 106; Total number of losses: 20; Total Number of normals: 362.
Somatic mutations of TBX2:
Generating mutation plots.
Highly correlated genes for TBX2:
Showing top 20/155 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBX2 | TMEM9 | 0.741406 | 3 | 0 | 3 |
| TBX2 | TRPA1 | 0.738043 | 4 | 0 | 4 |
| TBX2 | CHSY3 | 0.710078 | 4 | 0 | 4 |
| TBX2 | HEBP1 | 0.709468 | 3 | 0 | 3 |
| TBX2 | CYB5R3 | 0.695619 | 3 | 0 | 3 |
| TBX2 | CEMIP | 0.695592 | 3 | 0 | 3 |
| TBX2 | AK5 | 0.692201 | 4 | 0 | 3 |
| TBX2 | P4HA3 | 0.684311 | 4 | 0 | 3 |
| TBX2 | LONP1 | 0.683529 | 3 | 0 | 3 |
| TBX2 | DAB1 | 0.683102 | 5 | 0 | 3 |
| TBX2 | SMIM3 | 0.674455 | 3 | 0 | 3 |
| TBX2 | TLR9 | 0.672673 | 3 | 0 | 3 |
| TBX2 | CDC42EP2 | 0.666692 | 3 | 0 | 3 |
| TBX2 | THBS2 | 0.665064 | 4 | 0 | 3 |
| TBX2 | NKD2 | 0.664383 | 5 | 0 | 4 |
| TBX2 | MFNG | 0.661182 | 3 | 0 | 3 |
| TBX2 | ASAP1-IT2 | 0.658375 | 3 | 0 | 3 |
| TBX2 | SCARF2 | 0.655036 | 4 | 0 | 3 |
| TBX2 | CLTCL1 | 0.649158 | 3 | 0 | 3 |
| TBX2 | TFE3 | 0.642041 | 4 | 0 | 4 |
For details and further investigation, click here
