| Full name: double C2 domain alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 8448 | HGNC ID: HGNC:2985 | Ensembl Gene: ENSG00000149927 | OMIM ID: 604567 |
| Drug and gene relationship at DGIdb | |||
Expression of DOC2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOC2A | 8448 | 205744_at | 0.0841 | 0.8219 | |
| GSE20347 | DOC2A | 8448 | 205744_at | 0.1596 | 0.1074 | |
| GSE23400 | DOC2A | 8448 | 205744_at | -0.0477 | 0.3451 | |
| GSE26886 | DOC2A | 8448 | 205744_at | 0.2583 | 0.0353 | |
| GSE29001 | DOC2A | 8448 | 205744_at | 0.1213 | 0.4670 | |
| GSE38129 | DOC2A | 8448 | 205744_at | 0.1291 | 0.1244 | |
| GSE45670 | DOC2A | 8448 | 205744_at | 0.2996 | 0.0674 | |
| GSE53622 | DOC2A | 8448 | 13116 | -0.4343 | 0.0000 | |
| GSE53624 | DOC2A | 8448 | 13116 | 0.2008 | 0.0059 | |
| GSE63941 | DOC2A | 8448 | 205744_at | 0.5891 | 0.1184 | |
| GSE77861 | DOC2A | 8448 | 205744_at | -0.1105 | 0.4216 | |
| SRP133303 | DOC2A | 8448 | RNAseq | 0.8815 | 0.0721 | |
| SRP159526 | DOC2A | 8448 | RNAseq | 1.7659 | 0.0001 | |
| SRP219564 | DOC2A | 8448 | RNAseq | 2.9155 | 0.0040 | |
| TCGA | DOC2A | 8448 | RNAseq | 2.3981 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DOC2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOC2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOC2A | 8448 | 5 | 5 | 20 | |
| GSE20123 | DOC2A | 8448 | 5 | 4 | 21 | |
| GSE43470 | DOC2A | 8448 | 3 | 3 | 37 | |
| GSE46452 | DOC2A | 8448 | 38 | 1 | 20 | |
| GSE47630 | DOC2A | 8448 | 11 | 7 | 22 | |
| GSE54993 | DOC2A | 8448 | 3 | 5 | 62 | |
| GSE54994 | DOC2A | 8448 | 5 | 9 | 39 | |
| GSE60625 | DOC2A | 8448 | 4 | 0 | 7 | |
| GSE74703 | DOC2A | 8448 | 3 | 2 | 31 | |
| GSE74704 | DOC2A | 8448 | 3 | 2 | 15 | |
| TCGA | DOC2A | 8448 | 20 | 11 | 65 |
Total number of gains: 100; Total number of losses: 49; Total Number of normals: 339.
Somatic mutations of DOC2A:
Generating mutation plots.
Highly correlated genes for DOC2A:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOC2A | SRL | 0.698961 | 3 | 0 | 3 |
| DOC2A | RHBDL3 | 0.694294 | 3 | 0 | 3 |
| DOC2A | MAG | 0.691933 | 3 | 0 | 3 |
| DOC2A | NKX1-1 | 0.68668 | 3 | 0 | 3 |
| DOC2A | MDGA2 | 0.664351 | 3 | 0 | 3 |
| DOC2A | FRMD5 | 0.658518 | 3 | 0 | 3 |
| DOC2A | NKX2-5 | 0.628595 | 6 | 0 | 5 |
| DOC2A | DEPDC5 | 0.620992 | 4 | 0 | 3 |
| DOC2A | RHOT2 | 0.618343 | 4 | 0 | 3 |
| DOC2A | CCR10 | 0.617071 | 3 | 0 | 3 |
| DOC2A | PANX2 | 0.614854 | 4 | 0 | 3 |
| DOC2A | TNFSF18 | 0.612793 | 4 | 0 | 3 |
| DOC2A | CKM | 0.612439 | 3 | 0 | 3 |
| DOC2A | CCDC151 | 0.612187 | 4 | 0 | 3 |
| DOC2A | CER1 | 0.610546 | 3 | 0 | 3 |
| DOC2A | PAX5 | 0.606889 | 3 | 0 | 3 |
| DOC2A | ZC3H3 | 0.604001 | 3 | 0 | 3 |
| DOC2A | FAM167B | 0.601326 | 4 | 0 | 3 |
| DOC2A | RAB11B | 0.595743 | 5 | 0 | 4 |
| DOC2A | MOSPD3 | 0.593211 | 5 | 0 | 5 |
For details and further investigation, click here
