| Full name: nicotinamide nucleotide adenylyltransferase 3 | Alias Symbol: PNAT3 | ||
| Type: protein-coding gene | Cytoband: 3q23 | ||
| Entrez ID: 349565 | HGNC ID: HGNC:20989 | Ensembl Gene: ENSG00000163864 | OMIM ID: 608702 |
| Drug and gene relationship at DGIdb | |||
Expression of NMNAT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NMNAT3 | 349565 | 228090_at | 0.9136 | 0.2906 | |
| GSE26886 | NMNAT3 | 349565 | 228090_at | 1.2720 | 0.0001 | |
| GSE45670 | NMNAT3 | 349565 | 228090_at | 0.6198 | 0.0488 | |
| GSE53622 | NMNAT3 | 349565 | 7508 | 0.6382 | 0.0000 | |
| GSE53624 | NMNAT3 | 349565 | 7508 | 0.8500 | 0.0000 | |
| GSE63941 | NMNAT3 | 349565 | 228090_at | 2.0041 | 0.0532 | |
| GSE77861 | NMNAT3 | 349565 | 243738_at | 0.0380 | 0.8714 | |
| GSE97050 | NMNAT3 | 349565 | A_24_P260134 | 0.2033 | 0.7127 | |
| SRP007169 | NMNAT3 | 349565 | RNAseq | 1.8738 | 0.0004 | |
| SRP008496 | NMNAT3 | 349565 | RNAseq | 2.3490 | 0.0000 | |
| SRP064894 | NMNAT3 | 349565 | RNAseq | 0.4975 | 0.0546 | |
| SRP133303 | NMNAT3 | 349565 | RNAseq | 0.6687 | 0.0001 | |
| SRP159526 | NMNAT3 | 349565 | RNAseq | 1.3850 | 0.0028 | |
| SRP193095 | NMNAT3 | 349565 | RNAseq | 1.3246 | 0.0000 | |
| SRP219564 | NMNAT3 | 349565 | RNAseq | 0.1653 | 0.8486 | |
| TCGA | NMNAT3 | 349565 | RNAseq | 0.1839 | 0.2600 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by NMNAT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NMNAT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NMNAT3 | 349565 | 18 | 0 | 12 | |
| GSE20123 | NMNAT3 | 349565 | 18 | 0 | 12 | |
| GSE43470 | NMNAT3 | 349565 | 22 | 0 | 21 | |
| GSE46452 | NMNAT3 | 349565 | 15 | 4 | 40 | |
| GSE47630 | NMNAT3 | 349565 | 19 | 3 | 18 | |
| GSE54993 | NMNAT3 | 349565 | 2 | 8 | 60 | |
| GSE54994 | NMNAT3 | 349565 | 32 | 2 | 19 | |
| GSE60625 | NMNAT3 | 349565 | 0 | 6 | 5 | |
| GSE74703 | NMNAT3 | 349565 | 19 | 0 | 17 | |
| GSE74704 | NMNAT3 | 349565 | 12 | 0 | 8 | |
| TCGA | NMNAT3 | 349565 | 61 | 4 | 31 |
Total number of gains: 218; Total number of losses: 27; Total Number of normals: 243.
Somatic mutations of NMNAT3:
Generating mutation plots.
Highly correlated genes for NMNAT3:
Showing top 20/241 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NMNAT3 | PODXL2 | 0.739743 | 3 | 0 | 3 |
| NMNAT3 | LSM10 | 0.725446 | 3 | 0 | 3 |
| NMNAT3 | PQBP1 | 0.722116 | 4 | 0 | 4 |
| NMNAT3 | SULT1A1 | 0.690474 | 3 | 0 | 3 |
| NMNAT3 | ZNF670 | 0.688596 | 3 | 0 | 3 |
| NMNAT3 | CUX1 | 0.681316 | 3 | 0 | 3 |
| NMNAT3 | CCNB1IP1 | 0.677627 | 3 | 0 | 3 |
| NMNAT3 | COMMD2 | 0.663312 | 3 | 0 | 3 |
| NMNAT3 | MSLN | 0.662863 | 3 | 0 | 3 |
| NMNAT3 | DNAJC19 | 0.660968 | 4 | 0 | 3 |
| NMNAT3 | RASEF | 0.656853 | 3 | 0 | 3 |
| NMNAT3 | HPS3 | 0.65495 | 3 | 0 | 3 |
| NMNAT3 | ZC3HAV1L | 0.65168 | 3 | 0 | 3 |
| NMNAT3 | FADD | 0.649594 | 3 | 0 | 3 |
| NMNAT3 | ZHX2 | 0.647581 | 4 | 0 | 3 |
| NMNAT3 | URI1 | 0.643178 | 3 | 0 | 3 |
| NMNAT3 | CHKA | 0.64127 | 3 | 0 | 3 |
| NMNAT3 | ALG1 | 0.640592 | 3 | 0 | 3 |
| NMNAT3 | RANGRF | 0.638289 | 3 | 0 | 3 |
| NMNAT3 | TIMM9 | 0.635413 | 4 | 0 | 4 |
For details and further investigation, click here
