| Full name: mesothelin | Alias Symbol: CAK1|MPF | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 10232 | HGNC ID: HGNC:7371 | Ensembl Gene: ENSG00000102854 | OMIM ID: 601051 |
| Drug and gene relationship at DGIdb | |||
Expression of MSLN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MSLN | 10232 | 204885_s_at | 0.9511 | 0.6051 | |
| GSE20347 | MSLN | 10232 | 204885_s_at | 0.1602 | 0.6249 | |
| GSE23400 | MSLN | 10232 | 204885_s_at | -0.0482 | 0.7245 | |
| GSE26886 | MSLN | 10232 | 204885_s_at | 0.5236 | 0.0305 | |
| GSE29001 | MSLN | 10232 | 204885_s_at | 0.4079 | 0.2780 | |
| GSE38129 | MSLN | 10232 | 204885_s_at | 0.1003 | 0.7275 | |
| GSE45670 | MSLN | 10232 | 204885_s_at | 0.1363 | 0.6421 | |
| GSE53622 | MSLN | 10232 | 48973 | -0.1115 | 0.6929 | |
| GSE53624 | MSLN | 10232 | 48973 | -0.6678 | 0.0026 | |
| GSE63941 | MSLN | 10232 | 204885_s_at | 0.8089 | 0.3923 | |
| GSE77861 | MSLN | 10232 | 204885_s_at | -0.0997 | 0.6684 | |
| GSE97050 | MSLN | 10232 | A_23_P77529 | 2.4583 | 0.1481 | |
| SRP064894 | MSLN | 10232 | RNAseq | -2.2444 | 0.0001 | |
| SRP133303 | MSLN | 10232 | RNAseq | -2.6985 | 0.0000 | |
| SRP159526 | MSLN | 10232 | RNAseq | -3.6235 | 0.0000 | |
| TCGA | MSLN | 10232 | RNAseq | -0.8560 | 0.1116 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MSLN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MSLN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MSLN | 10232 | 5 | 5 | 20 | |
| GSE20123 | MSLN | 10232 | 5 | 4 | 21 | |
| GSE43470 | MSLN | 10232 | 4 | 7 | 32 | |
| GSE46452 | MSLN | 10232 | 38 | 1 | 20 | |
| GSE47630 | MSLN | 10232 | 13 | 6 | 21 | |
| GSE54993 | MSLN | 10232 | 3 | 5 | 62 | |
| GSE54994 | MSLN | 10232 | 5 | 9 | 39 | |
| GSE60625 | MSLN | 10232 | 4 | 0 | 7 | |
| GSE74703 | MSLN | 10232 | 4 | 5 | 27 | |
| GSE74704 | MSLN | 10232 | 3 | 2 | 15 | |
| TCGA | MSLN | 10232 | 20 | 14 | 62 |
Total number of gains: 104; Total number of losses: 58; Total Number of normals: 326.
Somatic mutations of MSLN:
Generating mutation plots.
Highly correlated genes for MSLN:
Showing top 20/37 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MSLN | DTNB | 0.700245 | 3 | 0 | 3 |
| MSLN | PRKD2 | 0.666968 | 3 | 0 | 3 |
| MSLN | RARRES1 | 0.66533 | 3 | 0 | 3 |
| MSLN | NMNAT3 | 0.662863 | 3 | 0 | 3 |
| MSLN | LYPD6B | 0.655965 | 4 | 0 | 3 |
| MSLN | SLC51A | 0.653109 | 3 | 0 | 3 |
| MSLN | POU4F1 | 0.651148 | 3 | 0 | 3 |
| MSLN | IGF2BP1 | 0.631668 | 3 | 0 | 3 |
| MSLN | BCL2L11 | 0.61636 | 3 | 0 | 3 |
| MSLN | EIF3B | 0.608441 | 3 | 0 | 3 |
| MSLN | SLC5A12 | 0.605378 | 3 | 0 | 3 |
| MSLN | BIK | 0.60527 | 5 | 0 | 4 |
| MSLN | MICALL2 | 0.60256 | 4 | 0 | 3 |
| MSLN | FAM227B | 0.600324 | 3 | 0 | 3 |
| MSLN | NABP2 | 0.596027 | 3 | 0 | 3 |
| MSLN | PXN | 0.594355 | 3 | 0 | 3 |
| MSLN | CEP128 | 0.592409 | 3 | 0 | 3 |
| MSLN | SLC25A21-AS1 | 0.588776 | 3 | 0 | 3 |
| MSLN | TAPBPL | 0.586507 | 4 | 0 | 3 |
| MSLN | XRCC1 | 0.585334 | 3 | 0 | 3 |
For details and further investigation, click here
