| Full name: phospholipase D family member 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 201164 | HGNC ID: HGNC:30447 | Ensembl Gene: ENSG00000179598 | OMIM ID: 614960 |
| Drug and gene relationship at DGIdb | |||
Expression of PLD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLD6 | 201164 | 244430_at | -0.1275 | 0.5859 | |
| GSE26886 | PLD6 | 201164 | 244430_at | -0.0016 | 0.9887 | |
| GSE45670 | PLD6 | 201164 | 244430_at | -0.1427 | 0.0764 | |
| GSE53622 | PLD6 | 201164 | 27596 | 0.6750 | 0.0000 | |
| GSE53624 | PLD6 | 201164 | 27596 | 0.9728 | 0.0000 | |
| GSE63941 | PLD6 | 201164 | 244430_at | 0.0332 | 0.8112 | |
| GSE77861 | PLD6 | 201164 | 244430_at | -0.1625 | 0.1223 | |
| GSE97050 | PLD6 | 201164 | A_23_P360626 | -0.1441 | 0.6642 | |
| SRP007169 | PLD6 | 201164 | RNAseq | 1.6198 | 0.0339 | |
| SRP064894 | PLD6 | 201164 | RNAseq | 0.9830 | 0.0018 | |
| SRP133303 | PLD6 | 201164 | RNAseq | -0.0084 | 0.9625 | |
| SRP159526 | PLD6 | 201164 | RNAseq | 1.9406 | 0.0000 | |
| SRP193095 | PLD6 | 201164 | RNAseq | 0.9524 | 0.0000 | |
| SRP219564 | PLD6 | 201164 | RNAseq | 1.4729 | 0.0063 | |
| TCGA | PLD6 | 201164 | RNAseq | 0.0383 | 0.7441 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PLD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLD6 | 201164 | 3 | 3 | 24 | |
| GSE20123 | PLD6 | 201164 | 3 | 4 | 23 | |
| GSE43470 | PLD6 | 201164 | 2 | 5 | 36 | |
| GSE46452 | PLD6 | 201164 | 34 | 1 | 24 | |
| GSE47630 | PLD6 | 201164 | 7 | 1 | 32 | |
| GSE54993 | PLD6 | 201164 | 3 | 3 | 64 | |
| GSE54994 | PLD6 | 201164 | 6 | 5 | 42 | |
| GSE60625 | PLD6 | 201164 | 4 | 0 | 7 | |
| GSE74703 | PLD6 | 201164 | 2 | 2 | 32 | |
| GSE74704 | PLD6 | 201164 | 2 | 1 | 17 | |
| TCGA | PLD6 | 201164 | 18 | 23 | 55 |
Total number of gains: 84; Total number of losses: 48; Total Number of normals: 356.
Somatic mutations of PLD6:
Generating mutation plots.
Highly correlated genes for PLD6:
Showing top 20/87 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLD6 | CCDC97 | 0.741499 | 3 | 0 | 3 |
| PLD6 | MAP1S | 0.738282 | 3 | 0 | 3 |
| PLD6 | NDUFB11 | 0.733725 | 3 | 0 | 3 |
| PLD6 | ANKRD65 | 0.728723 | 3 | 0 | 3 |
| PLD6 | NOXO1 | 0.725658 | 3 | 0 | 3 |
| PLD6 | JPH2 | 0.717135 | 3 | 0 | 3 |
| PLD6 | ZNF155 | 0.707026 | 3 | 0 | 3 |
| PLD6 | CD2BP2 | 0.69655 | 3 | 0 | 3 |
| PLD6 | TNFRSF8 | 0.69634 | 3 | 0 | 3 |
| PLD6 | SETD1A | 0.696337 | 3 | 0 | 3 |
| PLD6 | ZNF256 | 0.692309 | 3 | 0 | 3 |
| PLD6 | RAB3GAP2 | 0.691988 | 3 | 0 | 3 |
| PLD6 | NOTCH4 | 0.691172 | 3 | 0 | 3 |
| PLD6 | TMEM201 | 0.683501 | 3 | 0 | 3 |
| PLD6 | MAST2 | 0.681698 | 4 | 0 | 4 |
| PLD6 | FADS1 | 0.681535 | 3 | 0 | 3 |
| PLD6 | SLC4A8 | 0.673374 | 3 | 0 | 3 |
| PLD6 | AKAP7 | 0.670836 | 3 | 0 | 3 |
| PLD6 | KRTAP5-8 | 0.667373 | 3 | 0 | 3 |
| PLD6 | ERCC2 | 0.665936 | 3 | 0 | 3 |
For details and further investigation, click here
