| Full name: nephrocystin 1 | Alias Symbol: JBTS4|SLSN1 | ||
| Type: protein-coding gene | Cytoband: 2q13 | ||
| Entrez ID: 4867 | HGNC ID: HGNC:7905 | Ensembl Gene: ENSG00000144061 | OMIM ID: 607100 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NPHP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPHP1 | 4867 | 238843_at | 0.6139 | 0.1070 | |
| GSE20347 | NPHP1 | 4867 | 206285_at | 0.1043 | 0.1062 | |
| GSE23400 | NPHP1 | 4867 | 206285_at | -0.0496 | 0.0174 | |
| GSE26886 | NPHP1 | 4867 | 238844_s_at | 0.3549 | 0.0027 | |
| GSE29001 | NPHP1 | 4867 | 206285_at | -0.2071 | 0.2272 | |
| GSE38129 | NPHP1 | 4867 | 206285_at | -0.0098 | 0.8926 | |
| GSE45670 | NPHP1 | 4867 | 238843_at | 0.3078 | 0.0874 | |
| GSE53622 | NPHP1 | 4867 | 89878 | -0.1358 | 0.5108 | |
| GSE53624 | NPHP1 | 4867 | 89878 | 0.0685 | 0.6220 | |
| GSE63941 | NPHP1 | 4867 | 238843_at | 0.6823 | 0.0315 | |
| GSE77861 | NPHP1 | 4867 | 238843_at | 0.0895 | 0.6451 | |
| GSE97050 | NPHP1 | 4867 | A_24_P88801 | -0.3621 | 0.2306 | |
| SRP007169 | NPHP1 | 4867 | RNAseq | 1.9346 | 0.0375 | |
| SRP064894 | NPHP1 | 4867 | RNAseq | 0.1843 | 0.3483 | |
| SRP133303 | NPHP1 | 4867 | RNAseq | 0.2932 | 0.2678 | |
| SRP159526 | NPHP1 | 4867 | RNAseq | 1.0850 | 0.0411 | |
| SRP193095 | NPHP1 | 4867 | RNAseq | 0.4018 | 0.0334 | |
| SRP219564 | NPHP1 | 4867 | RNAseq | -0.1318 | 0.8627 | |
| TCGA | NPHP1 | 4867 | RNAseq | -0.2501 | 0.2350 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by NPHP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPHP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPHP1 | 4867 | 4 | 2 | 24 | |
| GSE20123 | NPHP1 | 4867 | 4 | 2 | 24 | |
| GSE43470 | NPHP1 | 4867 | 3 | 1 | 39 | |
| GSE46452 | NPHP1 | 4867 | 1 | 4 | 54 | |
| GSE47630 | NPHP1 | 4867 | 7 | 0 | 33 | |
| GSE54993 | NPHP1 | 4867 | 0 | 6 | 64 | |
| GSE54994 | NPHP1 | 4867 | 10 | 0 | 43 | |
| GSE60625 | NPHP1 | 4867 | 0 | 3 | 8 | |
| GSE74703 | NPHP1 | 4867 | 3 | 1 | 32 | |
| GSE74704 | NPHP1 | 4867 | 2 | 2 | 16 | |
| TCGA | NPHP1 | 4867 | 32 | 5 | 59 |
Total number of gains: 66; Total number of losses: 26; Total Number of normals: 396.
Somatic mutations of NPHP1:
Generating mutation plots.
Highly correlated genes for NPHP1:
Showing top 20/354 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPHP1 | ZNF358 | 0.750354 | 3 | 0 | 3 |
| NPHP1 | TRPM4 | 0.744514 | 3 | 0 | 3 |
| NPHP1 | TNP2 | 0.735742 | 3 | 0 | 3 |
| NPHP1 | PWP1 | 0.732271 | 3 | 0 | 3 |
| NPHP1 | TIGD1 | 0.719511 | 3 | 0 | 3 |
| NPHP1 | POU2F1 | 0.701536 | 3 | 0 | 3 |
| NPHP1 | RAD23A | 0.697538 | 3 | 0 | 3 |
| NPHP1 | PNKD | 0.695126 | 3 | 0 | 3 |
| NPHP1 | NOSIP | 0.691119 | 3 | 0 | 3 |
| NPHP1 | THADA | 0.685247 | 3 | 0 | 3 |
| NPHP1 | IKZF3 | 0.68515 | 3 | 0 | 3 |
| NPHP1 | EPS8L3 | 0.680591 | 3 | 0 | 3 |
| NPHP1 | ECSIT | 0.678043 | 3 | 0 | 3 |
| NPHP1 | IFT88 | 0.677135 | 4 | 0 | 4 |
| NPHP1 | ZSCAN29 | 0.676063 | 3 | 0 | 3 |
| NPHP1 | NADK | 0.673558 | 4 | 0 | 4 |
| NPHP1 | IFNA7 | 0.672369 | 5 | 0 | 5 |
| NPHP1 | CPT1A | 0.670971 | 3 | 0 | 3 |
| NPHP1 | THEM4 | 0.669373 | 3 | 0 | 3 |
| NPHP1 | CYP2U1 | 0.669301 | 3 | 0 | 3 |
For details and further investigation, click here
