| Full name: PWP1 homolog, endonuclein | Alias Symbol: IEF-SSP-9502 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 11137 | HGNC ID: HGNC:17015 | Ensembl Gene: ENSG00000136045 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PWP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PWP1 | 11137 | 201606_s_at | 0.2727 | 0.4507 | |
| GSE20347 | PWP1 | 11137 | 201606_s_at | 0.4137 | 0.0072 | |
| GSE23400 | PWP1 | 11137 | 201608_s_at | 0.4782 | 0.0000 | |
| GSE26886 | PWP1 | 11137 | 201606_s_at | -0.1038 | 0.6827 | |
| GSE29001 | PWP1 | 11137 | 201606_s_at | 0.3134 | 0.2789 | |
| GSE38129 | PWP1 | 11137 | 201606_s_at | 0.4885 | 0.0011 | |
| GSE45670 | PWP1 | 11137 | 201606_s_at | 0.2762 | 0.0406 | |
| GSE53622 | PWP1 | 11137 | 39198 | 0.1542 | 0.0089 | |
| GSE53624 | PWP1 | 11137 | 39198 | 0.4288 | 0.0000 | |
| GSE63941 | PWP1 | 11137 | 201606_s_at | 0.5363 | 0.0189 | |
| GSE77861 | PWP1 | 11137 | 201606_s_at | 0.5503 | 0.0179 | |
| GSE97050 | PWP1 | 11137 | A_23_P395524 | 0.1328 | 0.5091 | |
| SRP007169 | PWP1 | 11137 | RNAseq | 0.5100 | 0.1712 | |
| SRP008496 | PWP1 | 11137 | RNAseq | 0.5999 | 0.0103 | |
| SRP064894 | PWP1 | 11137 | RNAseq | 0.2183 | 0.0360 | |
| SRP133303 | PWP1 | 11137 | RNAseq | 0.3124 | 0.0294 | |
| SRP159526 | PWP1 | 11137 | RNAseq | 0.2565 | 0.0987 | |
| SRP193095 | PWP1 | 11137 | RNAseq | 0.0331 | 0.7768 | |
| SRP219564 | PWP1 | 11137 | RNAseq | -0.1925 | 0.3854 | |
| TCGA | PWP1 | 11137 | RNAseq | 0.1471 | 0.0032 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PWP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PWP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PWP1 | 11137 | 5 | 3 | 22 | |
| GSE20123 | PWP1 | 11137 | 5 | 3 | 22 | |
| GSE43470 | PWP1 | 11137 | 2 | 1 | 40 | |
| GSE46452 | PWP1 | 11137 | 9 | 1 | 49 | |
| GSE47630 | PWP1 | 11137 | 9 | 1 | 30 | |
| GSE54993 | PWP1 | 11137 | 0 | 5 | 65 | |
| GSE54994 | PWP1 | 11137 | 4 | 2 | 47 | |
| GSE60625 | PWP1 | 11137 | 0 | 0 | 11 | |
| GSE74703 | PWP1 | 11137 | 2 | 0 | 34 | |
| GSE74704 | PWP1 | 11137 | 2 | 2 | 16 | |
| TCGA | PWP1 | 11137 | 21 | 10 | 65 |
Total number of gains: 59; Total number of losses: 28; Total Number of normals: 401.
Somatic mutations of PWP1:
Generating mutation plots.
Highly correlated genes for PWP1:
Showing top 20/1014 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PWP1 | NFE2L3 | 0.775261 | 3 | 0 | 3 |
| PWP1 | DYRK2 | 0.771725 | 3 | 0 | 3 |
| PWP1 | SFR1 | 0.75004 | 3 | 0 | 3 |
| PWP1 | STRN4 | 0.738035 | 3 | 0 | 3 |
| PWP1 | PHOSPHO2 | 0.736287 | 3 | 0 | 3 |
| PWP1 | CASP8AP2 | 0.735633 | 3 | 0 | 3 |
| PWP1 | NPHP1 | 0.732271 | 3 | 0 | 3 |
| PWP1 | DDX59 | 0.726663 | 3 | 0 | 3 |
| PWP1 | ZNF75A | 0.721724 | 3 | 0 | 3 |
| PWP1 | CBFA2T2 | 0.721125 | 3 | 0 | 3 |
| PWP1 | NAPEPLD | 0.720808 | 3 | 0 | 3 |
| PWP1 | TIFAB | 0.715832 | 3 | 0 | 3 |
| PWP1 | EXOC6 | 0.708937 | 3 | 0 | 3 |
| PWP1 | PTPN4 | 0.706213 | 4 | 0 | 3 |
| PWP1 | SRSF6 | 0.705877 | 4 | 0 | 3 |
| PWP1 | ZNF71 | 0.705792 | 3 | 0 | 3 |
| PWP1 | FAM76B | 0.70564 | 3 | 0 | 3 |
| PWP1 | AMD1 | 0.695501 | 3 | 0 | 3 |
| PWP1 | GOLIM4 | 0.694199 | 5 | 0 | 5 |
| PWP1 | EIF3C | 0.692151 | 4 | 0 | 3 |
For details and further investigation, click here
