| Full name: aldehyde dehydrogenase 1 family member A2 | Alias Symbol: RALDH2 | ||
| Type: protein-coding gene | Cytoband: 15q21.3 | ||
| Entrez ID: 8854 | HGNC ID: HGNC:15472 | Ensembl Gene: ENSG00000128918 | OMIM ID: 603687 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH1A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH1A2 | 8854 | 207015_s_at | -0.3102 | 0.2846 | |
| GSE20347 | ALDH1A2 | 8854 | 207015_s_at | -0.0609 | 0.4062 | |
| GSE23400 | ALDH1A2 | 8854 | 207015_s_at | -0.1088 | 0.0029 | |
| GSE26886 | ALDH1A2 | 8854 | 207015_s_at | 0.2020 | 0.1564 | |
| GSE29001 | ALDH1A2 | 8854 | 207015_s_at | -0.1603 | 0.3382 | |
| GSE38129 | ALDH1A2 | 8854 | 207015_s_at | -0.1692 | 0.0713 | |
| GSE45670 | ALDH1A2 | 8854 | 207015_s_at | -0.0242 | 0.8361 | |
| GSE53622 | ALDH1A2 | 8854 | 59528 | -1.9581 | 0.0000 | |
| GSE53624 | ALDH1A2 | 8854 | 16657 | -1.8390 | 0.0000 | |
| GSE63941 | ALDH1A2 | 8854 | 207015_s_at | 0.3488 | 0.1491 | |
| GSE77861 | ALDH1A2 | 8854 | 207015_s_at | -0.0620 | 0.5858 | |
| GSE97050 | ALDH1A2 | 8854 | A_24_P73577 | -1.1137 | 0.1104 | |
| SRP064894 | ALDH1A2 | 8854 | RNAseq | -0.4366 | 0.3655 | |
| SRP133303 | ALDH1A2 | 8854 | RNAseq | -1.8392 | 0.0000 | |
| SRP159526 | ALDH1A2 | 8854 | RNAseq | 0.3852 | 0.6211 | |
| TCGA | ALDH1A2 | 8854 | RNAseq | -1.6646 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ALDH1A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH1A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH1A2 | 8854 | 6 | 4 | 20 | |
| GSE20123 | ALDH1A2 | 8854 | 6 | 3 | 21 | |
| GSE43470 | ALDH1A2 | 8854 | 4 | 4 | 35 | |
| GSE46452 | ALDH1A2 | 8854 | 3 | 7 | 49 | |
| GSE47630 | ALDH1A2 | 8854 | 8 | 10 | 22 | |
| GSE54993 | ALDH1A2 | 8854 | 5 | 6 | 59 | |
| GSE54994 | ALDH1A2 | 8854 | 6 | 8 | 39 | |
| GSE60625 | ALDH1A2 | 8854 | 4 | 0 | 7 | |
| GSE74703 | ALDH1A2 | 8854 | 4 | 3 | 29 | |
| GSE74704 | ALDH1A2 | 8854 | 2 | 3 | 15 | |
| TCGA | ALDH1A2 | 8854 | 10 | 17 | 69 |
Total number of gains: 58; Total number of losses: 65; Total Number of normals: 365.
Somatic mutations of ALDH1A2:
Generating mutation plots.
Highly correlated genes for ALDH1A2:
Showing top 20/828 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH1A2 | XKR4 | 0.833345 | 4 | 0 | 4 |
| ALDH1A2 | ADAMTSL1 | 0.80166 | 4 | 0 | 4 |
| ALDH1A2 | CYP2U1 | 0.788187 | 4 | 0 | 4 |
| ALDH1A2 | CLEC3B | 0.779663 | 3 | 0 | 3 |
| ALDH1A2 | MYOT | 0.777292 | 4 | 0 | 4 |
| ALDH1A2 | RAB9B | 0.776823 | 4 | 0 | 4 |
| ALDH1A2 | NPY1R | 0.774181 | 3 | 0 | 3 |
| ALDH1A2 | MSRB3 | 0.773981 | 4 | 0 | 4 |
| ALDH1A2 | SLC35F1 | 0.7727 | 4 | 0 | 4 |
| ALDH1A2 | RUNX1T1 | 0.772422 | 5 | 0 | 5 |
| ALDH1A2 | ADCYAP1R1 | 0.767565 | 6 | 0 | 6 |
| ALDH1A2 | RAP1A | 0.755139 | 4 | 0 | 4 |
| ALDH1A2 | CASQ2 | 0.752068 | 5 | 0 | 5 |
| ALDH1A2 | KL | 0.751092 | 3 | 0 | 3 |
| ALDH1A2 | GNAQ | 0.749847 | 3 | 0 | 3 |
| ALDH1A2 | FILIP1 | 0.749417 | 4 | 0 | 4 |
| ALDH1A2 | RHOJ | 0.748604 | 4 | 0 | 4 |
| ALDH1A2 | CCDC136 | 0.748057 | 3 | 0 | 3 |
| ALDH1A2 | CHCHD10 | 0.746719 | 3 | 0 | 3 |
| ALDH1A2 | TNFSF12 | 0.746361 | 3 | 0 | 3 |
For details and further investigation, click here
