| Full name: deltex E3 ubiquitin ligase 4 | Alias Symbol: KIAA0937|RNF155 | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 23220 | HGNC ID: HGNC:29151 | Ensembl Gene: ENSG00000110042 | OMIM ID: 616110 |
| Drug and gene relationship at DGIdb | |||
DTX4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of DTX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DTX4 | 23220 | 212611_at | 1.2322 | 0.0734 | |
| GSE20347 | DTX4 | 23220 | 212611_at | 0.4370 | 0.0025 | |
| GSE23400 | DTX4 | 23220 | 212611_at | 0.1724 | 0.0240 | |
| GSE26886 | DTX4 | 23220 | 212611_at | 0.3649 | 0.2757 | |
| GSE29001 | DTX4 | 23220 | 212611_at | 0.2296 | 0.3338 | |
| GSE38129 | DTX4 | 23220 | 212611_at | 0.1757 | 0.3174 | |
| GSE45670 | DTX4 | 23220 | 212611_at | 0.0594 | 0.8302 | |
| GSE53622 | DTX4 | 23220 | 31374 | 0.6498 | 0.0000 | |
| GSE53624 | DTX4 | 23220 | 40966 | 0.6760 | 0.0000 | |
| GSE63941 | DTX4 | 23220 | 212611_at | -1.0558 | 0.2936 | |
| GSE77861 | DTX4 | 23220 | 212611_at | 0.1143 | 0.6093 | |
| GSE97050 | DTX4 | 23220 | A_24_P158718 | 0.1712 | 0.4731 | |
| SRP007169 | DTX4 | 23220 | RNAseq | 1.6209 | 0.0106 | |
| SRP064894 | DTX4 | 23220 | RNAseq | 0.3720 | 0.1604 | |
| SRP133303 | DTX4 | 23220 | RNAseq | 0.2867 | 0.2572 | |
| SRP159526 | DTX4 | 23220 | RNAseq | 0.4657 | 0.3211 | |
| SRP193095 | DTX4 | 23220 | RNAseq | 0.0253 | 0.9410 | |
| SRP219564 | DTX4 | 23220 | RNAseq | 0.8440 | 0.0001 | |
| TCGA | DTX4 | 23220 | RNAseq | -0.2283 | 0.0356 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DTX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DTX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DTX4 | 23220 | 1 | 5 | 24 | |
| GSE20123 | DTX4 | 23220 | 1 | 5 | 24 | |
| GSE43470 | DTX4 | 23220 | 1 | 5 | 37 | |
| GSE46452 | DTX4 | 23220 | 9 | 4 | 46 | |
| GSE47630 | DTX4 | 23220 | 3 | 8 | 29 | |
| GSE54993 | DTX4 | 23220 | 3 | 0 | 67 | |
| GSE54994 | DTX4 | 23220 | 5 | 6 | 42 | |
| GSE60625 | DTX4 | 23220 | 0 | 3 | 8 | |
| GSE74703 | DTX4 | 23220 | 1 | 3 | 32 | |
| GSE74704 | DTX4 | 23220 | 1 | 4 | 15 | |
| TCGA | DTX4 | 23220 | 14 | 10 | 72 |
Total number of gains: 39; Total number of losses: 53; Total Number of normals: 396.
Somatic mutations of DTX4:
Generating mutation plots.
Highly correlated genes for DTX4:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DTX4 | C12orf49 | 0.835974 | 3 | 0 | 3 |
| DTX4 | UMPS | 0.773187 | 3 | 0 | 3 |
| DTX4 | MFHAS1 | 0.763832 | 3 | 0 | 3 |
| DTX4 | KIAA0100 | 0.760933 | 3 | 0 | 3 |
| DTX4 | FAM53B | 0.759109 | 3 | 0 | 3 |
| DTX4 | LRRC34 | 0.756577 | 3 | 0 | 3 |
| DTX4 | POP5 | 0.756104 | 3 | 0 | 3 |
| DTX4 | NUP107 | 0.751905 | 3 | 0 | 3 |
| DTX4 | C1orf112 | 0.751412 | 3 | 0 | 3 |
| DTX4 | CPNE1 | 0.745153 | 3 | 0 | 3 |
| DTX4 | TRIAP1 | 0.740989 | 3 | 0 | 3 |
| DTX4 | ZNF740 | 0.737925 | 3 | 0 | 3 |
| DTX4 | C1orf174 | 0.734903 | 3 | 0 | 3 |
| DTX4 | TULP4 | 0.733914 | 3 | 0 | 3 |
| DTX4 | RRP36 | 0.727284 | 3 | 0 | 3 |
| DTX4 | TMPO | 0.726389 | 3 | 0 | 3 |
| DTX4 | CALML5 | 0.72595 | 3 | 0 | 3 |
| DTX4 | UBE2O | 0.722735 | 3 | 0 | 3 |
| DTX4 | NQO2 | 0.714391 | 3 | 0 | 3 |
| DTX4 | PDPR | 0.712785 | 3 | 0 | 3 |
For details and further investigation, click here
