| Full name: neuregulin 2 | Alias Symbol: Don-1|NTAK|HRG2 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 9542 | HGNC ID: HGNC:7998 | Ensembl Gene: ENSG00000158458 | OMIM ID: 603818 |
| Drug and gene relationship at DGIdb | |||
NRG2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04012 | ErbB signaling pathway |
Expression of NRG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NRG2 | 9542 | 206879_s_at | -0.5071 | 0.2842 | |
| GSE20347 | NRG2 | 9542 | 206879_s_at | -0.3211 | 0.0032 | |
| GSE23400 | NRG2 | 9542 | 208062_s_at | -0.0878 | 0.0306 | |
| GSE26886 | NRG2 | 9542 | 242303_at | -0.1544 | 0.1326 | |
| GSE29001 | NRG2 | 9542 | 206879_s_at | -0.7579 | 0.0000 | |
| GSE38129 | NRG2 | 9542 | 206879_s_at | -0.5088 | 0.0000 | |
| GSE45670 | NRG2 | 9542 | 242303_at | -0.3107 | 0.0019 | |
| GSE53622 | NRG2 | 9542 | 5812 | -0.1719 | 0.0679 | |
| GSE53624 | NRG2 | 9542 | 53200 | -2.8417 | 0.0000 | |
| GSE63941 | NRG2 | 9542 | 242303_at | 0.0873 | 0.5946 | |
| GSE77861 | NRG2 | 9542 | 206879_s_at | -0.2362 | 0.0885 | |
| GSE97050 | NRG2 | 9542 | A_33_P3395513 | -0.0968 | 0.6467 | |
| SRP064894 | NRG2 | 9542 | RNAseq | -2.7892 | 0.0000 | |
| SRP133303 | NRG2 | 9542 | RNAseq | -2.9313 | 0.0000 | |
| SRP159526 | NRG2 | 9542 | RNAseq | -3.6900 | 0.0000 | |
| SRP219564 | NRG2 | 9542 | RNAseq | -0.3264 | 0.7142 | |
| TCGA | NRG2 | 9542 | RNAseq | -1.0888 | 0.0273 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by NRG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NRG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NRG2 | 9542 | 3 | 11 | 16 | |
| GSE20123 | NRG2 | 9542 | 4 | 11 | 15 | |
| GSE43470 | NRG2 | 9542 | 4 | 8 | 31 | |
| GSE46452 | NRG2 | 9542 | 0 | 27 | 32 | |
| GSE47630 | NRG2 | 9542 | 0 | 20 | 20 | |
| GSE54993 | NRG2 | 9542 | 9 | 1 | 60 | |
| GSE54994 | NRG2 | 9542 | 2 | 14 | 37 | |
| GSE60625 | NRG2 | 9542 | 0 | 0 | 11 | |
| GSE74703 | NRG2 | 9542 | 3 | 6 | 27 | |
| GSE74704 | NRG2 | 9542 | 3 | 5 | 12 | |
| TCGA | NRG2 | 9542 | 4 | 37 | 55 |
Total number of gains: 32; Total number of losses: 140; Total Number of normals: 316.
Somatic mutations of NRG2:
Generating mutation plots.
Highly correlated genes for NRG2:
Showing top 20/386 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NRG2 | MCF2L | 0.742819 | 3 | 0 | 3 |
| NRG2 | CCDC36 | 0.724426 | 3 | 0 | 3 |
| NRG2 | AVPR2 | 0.721726 | 3 | 0 | 3 |
| NRG2 | PTGDS | 0.721258 | 5 | 0 | 4 |
| NRG2 | SYT3 | 0.697544 | 3 | 0 | 3 |
| NRG2 | CLCN1 | 0.695154 | 3 | 0 | 3 |
| NRG2 | FBF1 | 0.68987 | 3 | 0 | 3 |
| NRG2 | SFRP1 | 0.687869 | 5 | 0 | 5 |
| NRG2 | NPPA | 0.683089 | 4 | 0 | 3 |
| NRG2 | TRH | 0.681539 | 4 | 0 | 4 |
| NRG2 | ATP6AP1L | 0.678423 | 4 | 0 | 3 |
| NRG2 | CNGA4 | 0.676122 | 3 | 0 | 3 |
| NRG2 | USH1C | 0.663994 | 4 | 0 | 3 |
| NRG2 | TP53TG5 | 0.663448 | 3 | 0 | 3 |
| NRG2 | BTNL8 | 0.6616 | 6 | 0 | 4 |
| NRG2 | OR2H2 | 0.657232 | 5 | 0 | 4 |
| NRG2 | TDRD1 | 0.654581 | 4 | 0 | 4 |
| NRG2 | HIGD1B | 0.653372 | 5 | 0 | 5 |
| NRG2 | CELF3 | 0.653303 | 4 | 0 | 3 |
| NRG2 | APOA4 | 0.651693 | 3 | 0 | 3 |
For details and further investigation, click here
