| Full name: secreted frizzled related protein 1 | Alias Symbol: SARP2|FRP|FRP-1 | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 6422 | HGNC ID: HGNC:10776 | Ensembl Gene: ENSG00000104332 | OMIM ID: 604156 |
| Drug and gene relationship at DGIdb | |||
SFRP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of SFRP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SFRP1 | 6422 | 202037_s_at | -1.2504 | 0.3126 | |
| GSE20347 | SFRP1 | 6422 | 202037_s_at | -0.9968 | 0.1629 | |
| GSE23400 | SFRP1 | 6422 | 202037_s_at | -0.8334 | 0.0000 | |
| GSE26886 | SFRP1 | 6422 | 202037_s_at | -0.0274 | 0.9715 | |
| GSE29001 | SFRP1 | 6422 | 202037_s_at | -0.2641 | 0.7675 | |
| GSE38129 | SFRP1 | 6422 | 202037_s_at | -1.6741 | 0.0025 | |
| GSE45670 | SFRP1 | 6422 | 202037_s_at | -2.4201 | 0.0001 | |
| GSE53622 | SFRP1 | 6422 | 80336 | -2.2717 | 0.0000 | |
| GSE53624 | SFRP1 | 6422 | 80336 | -2.6858 | 0.0000 | |
| GSE63941 | SFRP1 | 6422 | 202037_s_at | -5.7656 | 0.0004 | |
| GSE77861 | SFRP1 | 6422 | 202037_s_at | -0.8842 | 0.0016 | |
| GSE97050 | SFRP1 | 6422 | A_23_P10121 | -0.4431 | 0.2709 | |
| SRP064894 | SFRP1 | 6422 | RNAseq | -1.5829 | 0.0013 | |
| SRP133303 | SFRP1 | 6422 | RNAseq | -1.9739 | 0.0003 | |
| SRP219564 | SFRP1 | 6422 | RNAseq | 0.7506 | 0.4497 | |
| TCGA | SFRP1 | 6422 | RNAseq | -0.6643 | 0.0501 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by SFRP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SFRP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SFRP1 | 6422 | 9 | 5 | 16 | |
| GSE20123 | SFRP1 | 6422 | 9 | 6 | 15 | |
| GSE43470 | SFRP1 | 6422 | 9 | 6 | 28 | |
| GSE46452 | SFRP1 | 6422 | 19 | 5 | 35 | |
| GSE47630 | SFRP1 | 6422 | 22 | 1 | 17 | |
| GSE54993 | SFRP1 | 6422 | 1 | 16 | 53 | |
| GSE54994 | SFRP1 | 6422 | 18 | 8 | 27 | |
| GSE60625 | SFRP1 | 6422 | 3 | 0 | 8 | |
| GSE74703 | SFRP1 | 6422 | 8 | 5 | 23 | |
| GSE74704 | SFRP1 | 6422 | 8 | 2 | 10 | |
| TCGA | SFRP1 | 6422 | 38 | 21 | 37 |
Total number of gains: 144; Total number of losses: 75; Total Number of normals: 269.
Somatic mutations of SFRP1:
Generating mutation plots.
Highly correlated genes for SFRP1:
Showing top 20/323 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SFRP1 | ZCCHC18 | 0.734576 | 4 | 0 | 4 |
| SFRP1 | MGARP | 0.709575 | 3 | 0 | 3 |
| SFRP1 | LINC01315 | 0.696409 | 6 | 0 | 5 |
| SFRP1 | NFIX | 0.689509 | 7 | 0 | 6 |
| SFRP1 | NRG2 | 0.687869 | 5 | 0 | 5 |
| SFRP1 | ALDH8A1 | 0.686203 | 3 | 0 | 3 |
| SFRP1 | THNSL2 | 0.678299 | 3 | 0 | 3 |
| SFRP1 | PTN | 0.676754 | 4 | 0 | 3 |
| SFRP1 | EIF4E3 | 0.670595 | 5 | 0 | 5 |
| SFRP1 | TNR | 0.668109 | 3 | 0 | 3 |
| SFRP1 | THBS3 | 0.665592 | 3 | 0 | 3 |
| SFRP1 | TNXB | 0.66231 | 4 | 0 | 4 |
| SFRP1 | SUMF1 | 0.661957 | 4 | 0 | 4 |
| SFRP1 | STARD9 | 0.66034 | 3 | 0 | 3 |
| SFRP1 | CNTN4 | 0.6452 | 5 | 0 | 5 |
| SFRP1 | TMEM217 | 0.641516 | 3 | 0 | 3 |
| SFRP1 | FBLN7 | 0.641365 | 3 | 0 | 3 |
| SFRP1 | EPHX2 | 0.640887 | 5 | 0 | 5 |
| SFRP1 | BOC | 0.639253 | 6 | 0 | 5 |
| SFRP1 | FAM221A | 0.637089 | 3 | 0 | 3 |
For details and further investigation, click here
