| Full name: prostaglandin D2 synthase | Alias Symbol: PGDS|L-PGDS | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 5730 | HGNC ID: HGNC:9592 | Ensembl Gene: ENSG00000107317 | OMIM ID: 176803 |
| Drug and gene relationship at DGIdb | |||
Expression of PTGDS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTGDS | 5730 | 211748_x_at | -1.6340 | 0.1683 | |
| GSE20347 | PTGDS | 5730 | 211748_x_at | -0.5865 | 0.0148 | |
| GSE23400 | PTGDS | 5730 | 211748_x_at | -0.8827 | 0.0000 | |
| GSE26886 | PTGDS | 5730 | 211748_x_at | -0.3185 | 0.3346 | |
| GSE29001 | PTGDS | 5730 | 211748_x_at | -0.9439 | 0.0025 | |
| GSE38129 | PTGDS | 5730 | 212187_x_at | -1.1145 | 0.0007 | |
| GSE45670 | PTGDS | 5730 | 211748_x_at | -2.1398 | 0.0000 | |
| GSE53622 | PTGDS | 5730 | 8905 | -2.5206 | 0.0000 | |
| GSE53624 | PTGDS | 5730 | 133607 | -2.3217 | 0.0000 | |
| GSE63941 | PTGDS | 5730 | 211748_x_at | -1.6787 | 0.0002 | |
| GSE77861 | PTGDS | 5730 | 211748_x_at | 0.2510 | 0.3648 | |
| GSE97050 | PTGDS | 5730 | A_33_P3219811 | -0.0677 | 0.7911 | |
| SRP064894 | PTGDS | 5730 | RNAseq | -1.2885 | 0.0150 | |
| SRP133303 | PTGDS | 5730 | RNAseq | -2.9383 | 0.0000 | |
| SRP159526 | PTGDS | 5730 | RNAseq | -1.8992 | 0.0263 | |
| TCGA | PTGDS | 5730 | RNAseq | -0.8434 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by PTGDS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTGDS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTGDS | 5730 | 5 | 7 | 18 | |
| GSE20123 | PTGDS | 5730 | 5 | 7 | 18 | |
| GSE43470 | PTGDS | 5730 | 3 | 7 | 33 | |
| GSE46452 | PTGDS | 5730 | 6 | 13 | 40 | |
| GSE47630 | PTGDS | 5730 | 6 | 15 | 19 | |
| GSE54993 | PTGDS | 5730 | 3 | 3 | 64 | |
| GSE54994 | PTGDS | 5730 | 12 | 8 | 33 | |
| GSE60625 | PTGDS | 5730 | 0 | 0 | 11 | |
| GSE74703 | PTGDS | 5730 | 3 | 5 | 28 | |
| GSE74704 | PTGDS | 5730 | 3 | 5 | 12 | |
| TCGA | PTGDS | 5730 | 29 | 23 | 44 |
Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.
Somatic mutations of PTGDS:
Generating mutation plots.
Highly correlated genes for PTGDS:
Showing top 20/352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTGDS | ACKR1 | 0.820288 | 10 | 0 | 10 |
| PTGDS | LINC01082 | 0.779249 | 5 | 0 | 5 |
| PTGDS | MAMLD1 | 0.757056 | 3 | 0 | 3 |
| PTGDS | OR10G8 | 0.747218 | 3 | 0 | 3 |
| PTGDS | ENTPD1 | 0.731265 | 6 | 0 | 6 |
| PTGDS | P2RX5 | 0.729707 | 3 | 0 | 3 |
| PTGDS | HRCT1 | 0.722551 | 3 | 0 | 3 |
| PTGDS | NRG2 | 0.721258 | 5 | 0 | 4 |
| PTGDS | FAM163B | 0.717702 | 3 | 0 | 3 |
| PTGDS | SCARA5 | 0.715191 | 4 | 0 | 4 |
| PTGDS | LGI1 | 0.710458 | 9 | 0 | 9 |
| PTGDS | GREM2 | 0.705296 | 11 | 0 | 10 |
| PTGDS | NOSTRIN | 0.696294 | 6 | 0 | 6 |
| PTGDS | P2RY14 | 0.693996 | 11 | 0 | 10 |
| PTGDS | FASTK | 0.692489 | 3 | 0 | 3 |
| PTGDS | PDZRN3 | 0.682769 | 6 | 0 | 6 |
| PTGDS | TESC | 0.682108 | 8 | 0 | 7 |
| PTGDS | MIXL1 | 0.681836 | 3 | 0 | 3 |
| PTGDS | CTTNBP2 | 0.680358 | 6 | 0 | 6 |
| PTGDS | SHE | 0.679509 | 5 | 0 | 4 |
For details and further investigation, click here
