| Full name: neurotrophic receptor tyrosine kinase 2 | Alias Symbol: TRKB | ||
| Type: protein-coding gene | Cytoband: 9q21.33 | ||
| Entrez ID: 4915 | HGNC ID: HGNC:8032 | Ensembl Gene: ENSG00000148053 | OMIM ID: 600456 |
| Drug and gene relationship at DGIdb | |||
NTRK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04722 | Neurotrophin signaling pathway | |
| hsa05034 | Alcoholism |
Expression of NTRK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NTRK2 | 4915 | 221795_at | -0.7678 | 0.7116 | |
| GSE20347 | NTRK2 | 4915 | 221795_at | 1.1973 | 0.0604 | |
| GSE23400 | NTRK2 | 4915 | 207152_at | -0.0749 | 0.0454 | |
| GSE26886 | NTRK2 | 4915 | 221796_at | 1.6589 | 0.0116 | |
| GSE29001 | NTRK2 | 4915 | 221796_at | 0.8420 | 0.4199 | |
| GSE38129 | NTRK2 | 4915 | 221795_at | 0.9660 | 0.1438 | |
| GSE45670 | NTRK2 | 4915 | 221796_at | 0.5776 | 0.4555 | |
| GSE53622 | NTRK2 | 4915 | 108630 | 0.6254 | 0.0472 | |
| GSE53624 | NTRK2 | 4915 | 108630 | 0.7127 | 0.0115 | |
| GSE63941 | NTRK2 | 4915 | 221795_at | 2.0270 | 0.2988 | |
| GSE77861 | NTRK2 | 4915 | 221796_at | 3.8357 | 0.0018 | |
| GSE97050 | NTRK2 | 4915 | A_33_P3322804 | 0.2033 | 0.4124 | |
| SRP007169 | NTRK2 | 4915 | RNAseq | 4.7613 | 0.0000 | |
| SRP008496 | NTRK2 | 4915 | RNAseq | 4.9301 | 0.0000 | |
| SRP064894 | NTRK2 | 4915 | RNAseq | 1.7648 | 0.0035 | |
| SRP133303 | NTRK2 | 4915 | RNAseq | 1.1595 | 0.0664 | |
| SRP159526 | NTRK2 | 4915 | RNAseq | 3.0987 | 0.0000 | |
| TCGA | NTRK2 | 4915 | RNAseq | 0.6419 | 0.0257 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by NTRK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NTRK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NTRK2 | 4915 | 6 | 9 | 15 | |
| GSE20123 | NTRK2 | 4915 | 6 | 9 | 15 | |
| GSE43470 | NTRK2 | 4915 | 6 | 3 | 34 | |
| GSE46452 | NTRK2 | 4915 | 6 | 14 | 39 | |
| GSE47630 | NTRK2 | 4915 | 1 | 18 | 21 | |
| GSE54993 | NTRK2 | 4915 | 4 | 2 | 64 | |
| GSE54994 | NTRK2 | 4915 | 6 | 12 | 35 | |
| GSE60625 | NTRK2 | 4915 | 0 | 0 | 11 | |
| GSE74703 | NTRK2 | 4915 | 5 | 3 | 28 | |
| GSE74704 | NTRK2 | 4915 | 3 | 7 | 10 | |
| TCGA | NTRK2 | 4915 | 22 | 27 | 47 |
Total number of gains: 65; Total number of losses: 104; Total Number of normals: 319.
Somatic mutations of NTRK2:
Generating mutation plots.
Highly correlated genes for NTRK2:
Showing top 20/406 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NTRK2 | THAP10 | 0.768531 | 3 | 0 | 3 |
| NTRK2 | CLPTM1L | 0.721266 | 3 | 0 | 3 |
| NTRK2 | ANKRD23 | 0.710308 | 3 | 0 | 3 |
| NTRK2 | C12orf75 | 0.709539 | 3 | 0 | 3 |
| NTRK2 | WDR81 | 0.707617 | 4 | 0 | 4 |
| NTRK2 | KLF13 | 0.696997 | 3 | 0 | 3 |
| NTRK2 | SLC41A1 | 0.694741 | 3 | 0 | 3 |
| NTRK2 | SOX2-OT | 0.693946 | 7 | 0 | 7 |
| NTRK2 | C5orf22 | 0.693888 | 3 | 0 | 3 |
| NTRK2 | KCNE3 | 0.69188 | 5 | 0 | 5 |
| NTRK2 | VMA21 | 0.687075 | 3 | 0 | 3 |
| NTRK2 | DMRT2 | 0.686123 | 7 | 0 | 7 |
| NTRK2 | STAT2 | 0.684879 | 3 | 0 | 3 |
| NTRK2 | TMEM60 | 0.684874 | 3 | 0 | 3 |
| NTRK2 | TRRAP | 0.680896 | 4 | 0 | 3 |
| NTRK2 | WDR59 | 0.68079 | 3 | 0 | 3 |
| NTRK2 | ZNF343 | 0.679011 | 3 | 0 | 3 |
| NTRK2 | DMBT1 | 0.678143 | 3 | 0 | 3 |
| NTRK2 | HELZ | 0.676797 | 3 | 0 | 3 |
| NTRK2 | MSI2 | 0.676067 | 5 | 0 | 4 |
For details and further investigation, click here
