C5orf22

 

Full name: chromosome 5 open reading frame 22 Alias Symbol: FLJ11193
Type: protein-coding gene Cytoband: 5p13.3
Entrez ID: 55322 HGNC ID: HGNC:25639 Ensembl Gene: ENSG00000082213 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of C5orf22:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C5orf22 55322 203738_at 0.6136 0.1456
GSE20347 C5orf22 55322 203738_at 0.3772 0.0153
GSE23400 C5orf22 55322 203738_at 0.6308 0.0000
GSE26886 C5orf22 55322 203738_at 0.0362 0.9053
GSE29001 C5orf22 55322 203738_at 0.5483 0.0141
GSE38129 C5orf22 55322 203738_at 0.4508 0.0002
GSE45670 C5orf22 55322 203738_at 0.3194 0.0610
GSE53622 C5orf22 55322 13715 0.3566 0.0000
GSE53624 C5orf22 55322 13715 0.5476 0.0000
GSE63941 C5orf22 55322 203738_at 0.8765 0.0295
GSE77861 C5orf22 55322 203738_at 0.4305 0.1080
GSE97050 C5orf22 55322 A_23_P7761 0.4919 0.1243
SRP007169 C5orf22 55322 RNAseq 0.3525 0.3625
SRP008496 C5orf22 55322 RNAseq 0.4750 0.0696
SRP064894 C5orf22 55322 RNAseq 0.1758 0.4054
SRP133303 C5orf22 55322 RNAseq 0.5177 0.0173
SRP159526 C5orf22 55322 RNAseq 0.7853 0.0609
SRP193095 C5orf22 55322 RNAseq 0.0610 0.5830
SRP219564 C5orf22 55322 RNAseq -0.0878 0.7142
TCGA C5orf22 55322 RNAseq 0.1380 0.0188

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by C5orf22 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C5orf22:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C5orf22 55322 11 0 19
GSE20123 C5orf22 55322 11 0 19
GSE43470 C5orf22 55322 15 3 25
GSE46452 C5orf22 55322 6 21 32
GSE47630 C5orf22 55322 6 12 22
GSE54993 C5orf22 55322 5 4 61
GSE54994 C5orf22 55322 27 2 24
GSE60625 C5orf22 55322 0 0 11
GSE74703 C5orf22 55322 12 2 22
GSE74704 C5orf22 55322 10 0 10
TCGA C5orf22 55322 51 6 39

Total number of gains: 154; Total number of losses: 50; Total Number of normals: 284.  

 

Somatic mutations of C5orf22:

 

Generating mutation plots.

 

Highly correlated genes for C5orf22:

 

Showing top 20/980 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C5orf22ORAI10.821465303
C5orf22DDX100.758926303
C5orf22C12orf730.740738303
C5orf22STAT5B0.738138303
C5orf22EEFSEC0.737404303
C5orf22PIM20.734638303
C5orf22GPR1600.732772303
C5orf22ETV60.726351403
C5orf22C12orf660.712039303
C5orf22WDR810.710356303
C5orf22EIF3C0.707312303
C5orf22CENPV0.705326303
C5orf22ARHGAP90.704997303
C5orf22DDX540.702498404
C5orf22CELF10.70223303
C5orf22AEBP20.702108303
C5orf22VMA210.701512404
C5orf22INTS100.700375403
C5orf22TRUB10.694522404
C5orf22NTRK20.693888303

For details and further investigation, click here