| Full name: NUAK family kinase 2 | Alias Symbol: SNARK|FLJ90349 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 81788 | HGNC ID: HGNC:29558 | Ensembl Gene: ENSG00000163545 | OMIM ID: 608131 |
| Drug and gene relationship at DGIdb | |||
Expression of NUAK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | NUAK2 | 81788 | 64850 | -1.2165 | 0.0000 | |
| GSE53624 | NUAK2 | 81788 | 64850 | -1.3903 | 0.0000 | |
| GSE97050 | NUAK2 | 81788 | A_33_P3338166 | -0.2281 | 0.7797 | |
| SRP007169 | NUAK2 | 81788 | RNAseq | -2.6303 | 0.0000 | |
| SRP008496 | NUAK2 | 81788 | RNAseq | -2.8777 | 0.0000 | |
| SRP064894 | NUAK2 | 81788 | RNAseq | -2.8408 | 0.0000 | |
| SRP133303 | NUAK2 | 81788 | RNAseq | -1.3324 | 0.0000 | |
| SRP159526 | NUAK2 | 81788 | RNAseq | -2.1346 | 0.0000 | |
| SRP193095 | NUAK2 | 81788 | RNAseq | -0.8078 | 0.0002 | |
| SRP219564 | NUAK2 | 81788 | RNAseq | -1.8085 | 0.0752 | |
| TCGA | NUAK2 | 81788 | RNAseq | 0.5939 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by NUAK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUAK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUAK2 | 81788 | 11 | 0 | 19 | |
| GSE20123 | NUAK2 | 81788 | 11 | 0 | 19 | |
| GSE43470 | NUAK2 | 81788 | 6 | 0 | 37 | |
| GSE46452 | NUAK2 | 81788 | 3 | 1 | 55 | |
| GSE47630 | NUAK2 | 81788 | 14 | 0 | 26 | |
| GSE54993 | NUAK2 | 81788 | 0 | 6 | 64 | |
| GSE54994 | NUAK2 | 81788 | 15 | 0 | 38 | |
| GSE60625 | NUAK2 | 81788 | 0 | 0 | 11 | |
| GSE74703 | NUAK2 | 81788 | 6 | 0 | 30 | |
| GSE74704 | NUAK2 | 81788 | 5 | 0 | 15 | |
| TCGA | NUAK2 | 81788 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of NUAK2:
Generating mutation plots.
Highly correlated genes for NUAK2:
Showing top 20/532 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUAK2 | MPZL3 | 0.839287 | 3 | 0 | 3 |
| NUAK2 | DAPP1 | 0.833374 | 3 | 0 | 3 |
| NUAK2 | NIPAL1 | 0.822381 | 3 | 0 | 3 |
| NUAK2 | EPHA2 | 0.817342 | 4 | 0 | 4 |
| NUAK2 | PELI1 | 0.813422 | 3 | 0 | 3 |
| NUAK2 | PLIN3 | 0.810572 | 3 | 0 | 3 |
| NUAK2 | BARX2 | 0.802361 | 3 | 0 | 3 |
| NUAK2 | EPGN | 0.801912 | 3 | 0 | 3 |
| NUAK2 | EHD3 | 0.799134 | 3 | 0 | 3 |
| NUAK2 | ZDHHC13 | 0.797463 | 3 | 0 | 3 |
| NUAK2 | CCDC120 | 0.793001 | 3 | 0 | 3 |
| NUAK2 | OSTF1 | 0.790255 | 3 | 0 | 3 |
| NUAK2 | KCTD11 | 0.787763 | 3 | 0 | 3 |
| NUAK2 | ARHGAP32 | 0.784782 | 3 | 0 | 3 |
| NUAK2 | SLC16A6 | 0.784621 | 3 | 0 | 3 |
| NUAK2 | PGM2 | 0.784426 | 3 | 0 | 3 |
| NUAK2 | NSDHL | 0.784126 | 3 | 0 | 3 |
| NUAK2 | FAM110C | 0.783128 | 3 | 0 | 3 |
| NUAK2 | FAM83G | 0.782474 | 3 | 0 | 3 |
| NUAK2 | VASN | 0.782289 | 3 | 0 | 3 |
For details and further investigation, click here
