| Full name: NPHS1 adhesion molecule, nephrin | Alias Symbol: CNF|NPHN | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 4868 | HGNC ID: HGNC:7908 | Ensembl Gene: ENSG00000161270 | OMIM ID: 602716 |
| Drug and gene relationship at DGIdb | |||
Expression of NPHS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPHS1 | 4868 | 207673_at | 0.0972 | 0.6626 | |
| GSE20347 | NPHS1 | 4868 | 207673_at | 0.0180 | 0.7772 | |
| GSE23400 | NPHS1 | 4868 | 207673_at | -0.0297 | 0.3203 | |
| GSE26886 | NPHS1 | 4868 | 207673_at | 0.3087 | 0.0136 | |
| GSE29001 | NPHS1 | 4868 | 207673_at | 0.0079 | 0.9464 | |
| GSE38129 | NPHS1 | 4868 | 207673_at | 0.0072 | 0.9245 | |
| GSE45670 | NPHS1 | 4868 | 207673_at | 0.1601 | 0.0337 | |
| GSE53622 | NPHS1 | 4868 | 4559 | -0.1447 | 0.0659 | |
| GSE53624 | NPHS1 | 4868 | 4559 | -0.6310 | 0.0000 | |
| GSE63941 | NPHS1 | 4868 | 207673_at | 0.0624 | 0.6638 | |
| GSE77861 | NPHS1 | 4868 | 207673_at | 0.0251 | 0.8895 | |
| SRP133303 | NPHS1 | 4868 | RNAseq | -0.1214 | 0.6700 | |
| SRP159526 | NPHS1 | 4868 | RNAseq | -2.0961 | 0.0105 | |
| TCGA | NPHS1 | 4868 | RNAseq | -1.0073 | 0.3155 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NPHS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPHS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPHS1 | 4868 | 7 | 4 | 19 | |
| GSE20123 | NPHS1 | 4868 | 7 | 3 | 20 | |
| GSE43470 | NPHS1 | 4868 | 3 | 7 | 33 | |
| GSE46452 | NPHS1 | 4868 | 48 | 1 | 10 | |
| GSE47630 | NPHS1 | 4868 | 9 | 5 | 26 | |
| GSE54993 | NPHS1 | 4868 | 17 | 3 | 50 | |
| GSE54994 | NPHS1 | 4868 | 6 | 9 | 38 | |
| GSE60625 | NPHS1 | 4868 | 9 | 0 | 2 | |
| GSE74703 | NPHS1 | 4868 | 3 | 4 | 29 | |
| GSE74704 | NPHS1 | 4868 | 6 | 1 | 13 | |
| TCGA | NPHS1 | 4868 | 22 | 10 | 64 |
Total number of gains: 137; Total number of losses: 47; Total Number of normals: 304.
Somatic mutations of NPHS1:
Generating mutation plots.
Highly correlated genes for NPHS1:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPHS1 | MGAT5B | 0.711951 | 4 | 0 | 4 |
| NPHS1 | HIC2 | 0.70355 | 3 | 0 | 3 |
| NPHS1 | GPHB5 | 0.69883 | 3 | 0 | 3 |
| NPHS1 | NUMBL | 0.679484 | 3 | 0 | 3 |
| NPHS1 | FAIM2 | 0.678382 | 3 | 0 | 3 |
| NPHS1 | GPR137C | 0.670392 | 3 | 0 | 3 |
| NPHS1 | PICK1 | 0.66844 | 3 | 0 | 3 |
| NPHS1 | ATAD3B | 0.667816 | 3 | 0 | 3 |
| NPHS1 | FLT4 | 0.667351 | 5 | 0 | 5 |
| NPHS1 | A4GALT | 0.667001 | 3 | 0 | 3 |
| NPHS1 | C19orf81 | 0.663699 | 3 | 0 | 3 |
| NPHS1 | LCN1 | 0.663386 | 3 | 0 | 3 |
| NPHS1 | DPPA4 | 0.659837 | 3 | 0 | 3 |
| NPHS1 | SHISA4 | 0.655656 | 3 | 0 | 3 |
| NPHS1 | ANKRD24 | 0.647067 | 3 | 0 | 3 |
| NPHS1 | ERICH4 | 0.647048 | 5 | 0 | 4 |
| NPHS1 | TNNT2 | 0.640583 | 4 | 0 | 4 |
| NPHS1 | LINC00475 | 0.637099 | 3 | 0 | 3 |
| NPHS1 | BEST3 | 0.632222 | 4 | 0 | 4 |
| NPHS1 | C8G | 0.631841 | 4 | 0 | 4 |
For details and further investigation, click here
