| Full name: RAB guanine nucleotide exchange factor 1 | Alias Symbol: rabex-5|RABEX5 | ||
| Type: protein-coding gene | Cytoband: 7q11.21 | ||
| Entrez ID: 27342 | HGNC ID: HGNC:17676 | Ensembl Gene: ENSG00000154710 | OMIM ID: 609700 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RABGEF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RABGEF1 | 27342 | 235407_at | 0.3232 | 0.6084 | |
| GSE26886 | RABGEF1 | 27342 | 235407_at | 0.8584 | 0.0262 | |
| GSE45670 | RABGEF1 | 27342 | 235407_at | 0.4659 | 0.0274 | |
| GSE53622 | RABGEF1 | 27342 | 16647 | -0.7873 | 0.0000 | |
| GSE53624 | RABGEF1 | 27342 | 16647 | -0.5553 | 0.0000 | |
| GSE63941 | RABGEF1 | 27342 | 235407_at | -0.0730 | 0.8827 | |
| GSE77861 | RABGEF1 | 27342 | 235407_at | 0.2693 | 0.2214 | |
| GSE97050 | RABGEF1 | A_21_P0013322 | 0.1043 | 0.6474 | ||
| SRP007169 | RABGEF1 | 27342 | RNAseq | -1.2298 | 0.0065 | |
| SRP008496 | RABGEF1 | 27342 | RNAseq | -0.9747 | 0.0012 | |
| SRP064894 | RABGEF1 | 27342 | RNAseq | -0.3243 | 0.0743 | |
| SRP133303 | RABGEF1 | 27342 | RNAseq | -0.3425 | 0.0281 | |
| SRP159526 | RABGEF1 | 27342 | RNAseq | -0.2162 | 0.4241 | |
| SRP193095 | RABGEF1 | 27342 | RNAseq | -0.2042 | 0.1812 | |
| SRP219564 | RABGEF1 | 27342 | RNAseq | -0.5334 | 0.0865 | |
| TCGA | RABGEF1 | 27342 | RNAseq | -0.0597 | 0.2405 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RABGEF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RABGEF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RABGEF1 | 27342 | 11 | 2 | 17 | |
| GSE20123 | RABGEF1 | 27342 | 10 | 2 | 18 | |
| GSE43470 | RABGEF1 | 27342 | 3 | 1 | 39 | |
| GSE46452 | RABGEF1 | 27342 | 13 | 0 | 46 | |
| GSE47630 | RABGEF1 | 27342 | 7 | 1 | 32 | |
| GSE54993 | RABGEF1 | 27342 | 2 | 7 | 61 | |
| GSE54994 | RABGEF1 | 27342 | 12 | 4 | 37 | |
| GSE60625 | RABGEF1 | 27342 | 0 | 0 | 11 | |
| GSE74703 | RABGEF1 | 27342 | 3 | 1 | 32 | |
| GSE74704 | RABGEF1 | 27342 | 5 | 1 | 14 | |
| TCGA | RABGEF1 | 27342 | 46 | 7 | 43 |
Total number of gains: 112; Total number of losses: 26; Total Number of normals: 350.
Somatic mutations of RABGEF1:
Generating mutation plots.
Highly correlated genes for RABGEF1:
Showing top 20/69 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RABGEF1 | LCE3D | 0.712395 | 3 | 0 | 3 |
| RABGEF1 | DLX3 | 0.706624 | 3 | 0 | 3 |
| RABGEF1 | PINX1 | 0.694811 | 3 | 0 | 3 |
| RABGEF1 | NUMBL | 0.690601 | 3 | 0 | 3 |
| RABGEF1 | SFN | 0.653044 | 3 | 0 | 3 |
| RABGEF1 | STK17A | 0.650474 | 4 | 0 | 4 |
| RABGEF1 | RGS20 | 0.649762 | 4 | 0 | 3 |
| RABGEF1 | DUSP9 | 0.647686 | 3 | 0 | 3 |
| RABGEF1 | FOSL1 | 0.645855 | 4 | 0 | 4 |
| RABGEF1 | LTA4H | 0.636368 | 3 | 0 | 3 |
| RABGEF1 | SH3BP1 | 0.630144 | 3 | 0 | 3 |
| RABGEF1 | SRA1 | 0.626061 | 3 | 0 | 3 |
| RABGEF1 | ANKRD9 | 0.622958 | 4 | 0 | 3 |
| RABGEF1 | DUSP5 | 0.61909 | 3 | 0 | 3 |
| RABGEF1 | ARID5A | 0.618716 | 3 | 0 | 3 |
| RABGEF1 | FOLR3 | 0.616953 | 4 | 0 | 4 |
| RABGEF1 | KIAA1614-AS1 | 0.611444 | 3 | 0 | 3 |
| RABGEF1 | MICALCL | 0.610099 | 3 | 0 | 3 |
| RABGEF1 | SQLE | 0.609343 | 4 | 0 | 3 |
| RABGEF1 | YOD1 | 0.604695 | 3 | 0 | 3 |
For details and further investigation, click here
