| Full name: ribophorin I | Alias Symbol: OST1 | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 6184 | HGNC ID: HGNC:10381 | Ensembl Gene: ENSG00000163902 | OMIM ID: 180470 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPN1 | 6184 | 201011_at | 0.9872 | 0.0213 | |
| GSE20347 | RPN1 | 6184 | 201011_at | 0.6917 | 0.0000 | |
| GSE23400 | RPN1 | 6184 | 201011_at | 0.9672 | 0.0000 | |
| GSE26886 | RPN1 | 6184 | 201011_at | -0.1100 | 0.5998 | |
| GSE29001 | RPN1 | 6184 | 201011_at | 0.8068 | 0.0025 | |
| GSE38129 | RPN1 | 6184 | 201011_at | 0.7900 | 0.0000 | |
| GSE45670 | RPN1 | 6184 | 201011_at | 0.7992 | 0.0000 | |
| GSE53622 | RPN1 | 6184 | 141309 | 0.7515 | 0.0000 | |
| GSE53624 | RPN1 | 6184 | 141309 | 0.8984 | 0.0000 | |
| GSE63941 | RPN1 | 6184 | 201011_at | 0.0072 | 0.9868 | |
| GSE77861 | RPN1 | 6184 | 201011_at | 0.4494 | 0.0518 | |
| GSE97050 | RPN1 | 6184 | A_24_P63262 | 1.1902 | 0.0454 | |
| SRP007169 | RPN1 | 6184 | RNAseq | 0.9225 | 0.0252 | |
| SRP008496 | RPN1 | 6184 | RNAseq | 0.9922 | 0.0000 | |
| SRP064894 | RPN1 | 6184 | RNAseq | 1.2885 | 0.0000 | |
| SRP133303 | RPN1 | 6184 | RNAseq | 1.1397 | 0.0000 | |
| SRP159526 | RPN1 | 6184 | RNAseq | 0.9472 | 0.0000 | |
| SRP193095 | RPN1 | 6184 | RNAseq | 0.4947 | 0.0006 | |
| SRP219564 | RPN1 | 6184 | RNAseq | 0.9722 | 0.0020 | |
| TCGA | RPN1 | 6184 | RNAseq | 0.1201 | 0.0039 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by RPN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPN1 | 6184 | 17 | 0 | 13 | |
| GSE20123 | RPN1 | 6184 | 17 | 0 | 13 | |
| GSE43470 | RPN1 | 6184 | 19 | 0 | 24 | |
| GSE46452 | RPN1 | 6184 | 14 | 5 | 40 | |
| GSE47630 | RPN1 | 6184 | 18 | 3 | 19 | |
| GSE54993 | RPN1 | 6184 | 2 | 7 | 61 | |
| GSE54994 | RPN1 | 6184 | 31 | 3 | 19 | |
| GSE60625 | RPN1 | 6184 | 0 | 6 | 5 | |
| GSE74703 | RPN1 | 6184 | 17 | 0 | 19 | |
| GSE74704 | RPN1 | 6184 | 13 | 0 | 7 | |
| TCGA | RPN1 | 6184 | 58 | 5 | 33 |
Total number of gains: 206; Total number of losses: 29; Total Number of normals: 253.
Somatic mutations of RPN1:
Generating mutation plots.
Highly correlated genes for RPN1:
Showing top 20/2197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPN1 | MTBP | 0.834553 | 5 | 0 | 5 |
| RPN1 | LRRC58 | 0.8156 | 4 | 0 | 4 |
| RPN1 | NCAPG | 0.799788 | 5 | 0 | 5 |
| RPN1 | PLXNA1 | 0.795929 | 10 | 0 | 10 |
| RPN1 | PYCR2 | 0.795484 | 3 | 0 | 3 |
| RPN1 | PDIA4 | 0.794855 | 10 | 0 | 10 |
| RPN1 | SEC61A1 | 0.794103 | 11 | 0 | 10 |
| RPN1 | PPP1R9B | 0.788374 | 3 | 0 | 3 |
| RPN1 | TTK | 0.787305 | 7 | 0 | 7 |
| RPN1 | CMSS1 | 0.782011 | 5 | 0 | 5 |
| RPN1 | ORAI1 | 0.776522 | 3 | 0 | 3 |
| RPN1 | ZDHHC16 | 0.775306 | 5 | 0 | 5 |
| RPN1 | MCM2 | 0.773233 | 10 | 0 | 10 |
| RPN1 | FUS | 0.770012 | 10 | 0 | 10 |
| RPN1 | FLVCR1 | 0.769779 | 5 | 0 | 5 |
| RPN1 | MARCKSL1 | 0.76346 | 10 | 0 | 10 |
| RPN1 | ATP6V1C1 | 0.763432 | 10 | 0 | 10 |
| RPN1 | TTLL4 | 0.762573 | 3 | 0 | 3 |
| RPN1 | XXYLT1 | 0.761614 | 5 | 0 | 5 |
| RPN1 | DNAJB11 | 0.759807 | 8 | 0 | 7 |
For details and further investigation, click here
