| Full name: mannose-6-phosphate receptor, cation dependent | Alias Symbol: CD-MPR|CD-M6PR | ||
| Type: protein-coding gene | Cytoband: 12p13.31 | ||
| Entrez ID: 4074 | HGNC ID: HGNC:6752 | Ensembl Gene: ENSG00000003056 | OMIM ID: 154540 |
| Drug and gene relationship at DGIdb | |||
Expression of M6PR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | M6PR | 4074 | 200900_s_at | 0.4958 | 0.3729 | |
| GSE20347 | M6PR | 4074 | 200900_s_at | 0.5314 | 0.0682 | |
| GSE23400 | M6PR | 4074 | 200900_s_at | 0.8072 | 0.0000 | |
| GSE26886 | M6PR | 4074 | 200900_s_at | -0.9930 | 0.0149 | |
| GSE29001 | M6PR | 4074 | 200900_s_at | 0.7924 | 0.2108 | |
| GSE38129 | M6PR | 4074 | 200900_s_at | 0.7177 | 0.0104 | |
| GSE45670 | M6PR | 4074 | 200900_s_at | 0.5679 | 0.0093 | |
| GSE63941 | M6PR | 4074 | 200900_s_at | 1.6207 | 0.0004 | |
| GSE77861 | M6PR | 4074 | 200900_s_at | 0.9598 | 0.0455 | |
| GSE97050 | M6PR | 4074 | A_23_P204252 | 0.2892 | 0.4302 | |
| SRP007169 | M6PR | 4074 | RNAseq | 0.8246 | 0.0524 | |
| SRP008496 | M6PR | 4074 | RNAseq | 0.9451 | 0.0002 | |
| SRP064894 | M6PR | 4074 | RNAseq | 0.4379 | 0.0004 | |
| SRP133303 | M6PR | 4074 | RNAseq | 0.7512 | 0.0000 | |
| SRP159526 | M6PR | 4074 | RNAseq | 0.3956 | 0.1195 | |
| SRP193095 | M6PR | 4074 | RNAseq | 0.3052 | 0.0052 | |
| SRP219564 | M6PR | 4074 | RNAseq | 0.2895 | 0.4583 | |
| TCGA | M6PR | 4074 | RNAseq | 0.1428 | 0.0013 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by M6PR expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of M6PR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | M6PR | 4074 | 6 | 3 | 21 | |
| GSE20123 | M6PR | 4074 | 6 | 3 | 21 | |
| GSE43470 | M6PR | 4074 | 8 | 3 | 32 | |
| GSE46452 | M6PR | 4074 | 10 | 1 | 48 | |
| GSE47630 | M6PR | 4074 | 12 | 2 | 26 | |
| GSE54993 | M6PR | 4074 | 1 | 10 | 59 | |
| GSE54994 | M6PR | 4074 | 9 | 2 | 42 | |
| GSE60625 | M6PR | 4074 | 0 | 1 | 10 | |
| GSE74703 | M6PR | 4074 | 8 | 2 | 26 | |
| GSE74704 | M6PR | 4074 | 4 | 2 | 14 | |
| TCGA | M6PR | 4074 | 40 | 6 | 50 |
Total number of gains: 104; Total number of losses: 35; Total Number of normals: 349.
Somatic mutations of M6PR:
Generating mutation plots.
Highly correlated genes for M6PR:
Showing top 20/1050 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| M6PR | ORAI1 | 0.800708 | 4 | 0 | 4 |
| M6PR | DDX20 | 0.775267 | 3 | 0 | 3 |
| M6PR | C12orf60 | 0.763351 | 4 | 0 | 4 |
| M6PR | CCDC77 | 0.758305 | 4 | 0 | 4 |
| M6PR | STRAP | 0.75434 | 8 | 0 | 8 |
| M6PR | HSPBP1 | 0.749815 | 3 | 0 | 3 |
| M6PR | FAM120B | 0.74776 | 3 | 0 | 3 |
| M6PR | SENP1 | 0.746246 | 3 | 0 | 3 |
| M6PR | XXYLT1 | 0.737965 | 3 | 0 | 3 |
| M6PR | DUS3L | 0.737414 | 4 | 0 | 3 |
| M6PR | KLHDC3 | 0.736795 | 3 | 0 | 3 |
| M6PR | QSOX2 | 0.734394 | 3 | 0 | 3 |
| M6PR | VMA21 | 0.733099 | 4 | 0 | 4 |
| M6PR | RNF26 | 0.732293 | 3 | 0 | 3 |
| M6PR | SETX | 0.730451 | 5 | 0 | 5 |
| M6PR | EFTUD2 | 0.728582 | 5 | 0 | 5 |
| M6PR | SPNS1 | 0.727919 | 3 | 0 | 3 |
| M6PR | SMCR8 | 0.725997 | 3 | 0 | 3 |
| M6PR | EMG1 | 0.725874 | 11 | 0 | 10 |
| M6PR | SMARCE1 | 0.723043 | 3 | 0 | 3 |
For details and further investigation, click here
