| Full name: chromatin licensing and DNA replication factor 1 | Alias Symbol: DUP|RIS2 | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 81620 | HGNC ID: HGNC:24576 | Ensembl Gene: ENSG00000167513 | OMIM ID: 605525 |
| Drug and gene relationship at DGIdb | |||
Expression of CDT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDT1 | 81620 | 228868_x_at | 1.0672 | 0.0648 | |
| GSE20347 | CDT1 | 81620 | 209832_s_at | 0.8110 | 0.0000 | |
| GSE23400 | CDT1 | 81620 | 209832_s_at | 0.4387 | 0.0000 | |
| GSE26886 | CDT1 | 81620 | 228868_x_at | 1.3461 | 0.0000 | |
| GSE29001 | CDT1 | 81620 | 209832_s_at | 0.2985 | 0.0876 | |
| GSE38129 | CDT1 | 81620 | 209832_s_at | 1.1570 | 0.0000 | |
| GSE45670 | CDT1 | 81620 | 228868_x_at | 1.2219 | 0.0000 | |
| GSE53622 | CDT1 | 81620 | 71091 | 1.2566 | 0.0000 | |
| GSE53624 | CDT1 | 81620 | 71091 | 1.5879 | 0.0000 | |
| GSE63941 | CDT1 | 81620 | 228868_x_at | 3.8422 | 0.0000 | |
| GSE77861 | CDT1 | 81620 | 228868_x_at | 0.7329 | 0.0260 | |
| GSE97050 | CDT1 | 81620 | A_33_P3386262 | 0.6757 | 0.1210 | |
| SRP007169 | CDT1 | 81620 | RNAseq | 2.1816 | 0.0018 | |
| SRP064894 | CDT1 | 81620 | RNAseq | 1.4030 | 0.0000 | |
| SRP133303 | CDT1 | 81620 | RNAseq | 1.3300 | 0.0000 | |
| SRP159526 | CDT1 | 81620 | RNAseq | 1.9158 | 0.0000 | |
| SRP193095 | CDT1 | 81620 | RNAseq | 0.8987 | 0.0000 | |
| SRP219564 | CDT1 | 81620 | RNAseq | 1.5229 | 0.0374 | |
| TCGA | CDT1 | 81620 | RNAseq | 1.1891 | 0.0000 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by CDT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDT1 | 81620 | 4 | 3 | 23 | |
| GSE20123 | CDT1 | 81620 | 4 | 3 | 23 | |
| GSE43470 | CDT1 | 81620 | 1 | 13 | 29 | |
| GSE46452 | CDT1 | 81620 | 38 | 1 | 20 | |
| GSE47630 | CDT1 | 81620 | 11 | 9 | 20 | |
| GSE54993 | CDT1 | 81620 | 3 | 4 | 63 | |
| GSE54994 | CDT1 | 81620 | 9 | 11 | 33 | |
| GSE60625 | CDT1 | 81620 | 4 | 0 | 7 | |
| GSE74703 | CDT1 | 81620 | 1 | 9 | 26 | |
| GSE74704 | CDT1 | 81620 | 3 | 2 | 15 | |
| TCGA | CDT1 | 81620 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of CDT1:
Generating mutation plots.
Highly correlated genes for CDT1:
Showing top 20/1910 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDT1 | UBE2T | 0.826224 | 8 | 0 | 8 |
| CDT1 | SKA3 | 0.808914 | 7 | 0 | 7 |
| CDT1 | TPX2 | 0.806626 | 12 | 0 | 12 |
| CDT1 | KNSTRN | 0.805753 | 7 | 0 | 7 |
| CDT1 | CDCA2 | 0.804702 | 6 | 0 | 6 |
| CDT1 | MCM2 | 0.800396 | 11 | 0 | 11 |
| CDT1 | KIF22 | 0.800207 | 12 | 0 | 12 |
| CDT1 | ORAI1 | 0.798126 | 5 | 0 | 5 |
| CDT1 | CCNB2 | 0.795724 | 12 | 0 | 11 |
| CDT1 | MCM7 | 0.794914 | 11 | 0 | 11 |
| CDT1 | AURKB | 0.789912 | 12 | 0 | 12 |
| CDT1 | RNASEH2A | 0.786375 | 12 | 0 | 11 |
| CDT1 | DKC1 | 0.786305 | 3 | 0 | 3 |
| CDT1 | ESCO2 | 0.785891 | 7 | 0 | 7 |
| CDT1 | CENPN | 0.782233 | 13 | 0 | 12 |
| CDT1 | SPAG5 | 0.777484 | 12 | 0 | 12 |
| CDT1 | UBE2C | 0.776006 | 13 | 0 | 12 |
| CDT1 | BUB1B | 0.775571 | 9 | 0 | 9 |
| CDT1 | MCM6 | 0.77462 | 12 | 0 | 12 |
| CDT1 | MELK | 0.77286 | 11 | 0 | 11 |
For details and further investigation, click here
