| Full name: WD repeat and HMG-box DNA binding protein 1 | Alias Symbol: AND-1|CTF4|CHTF4 | ||
| Type: protein-coding gene | Cytoband: 14q22.2-q22.3 | ||
| Entrez ID: 11169 | HGNC ID: HGNC:23170 | Ensembl Gene: ENSG00000198554 | OMIM ID: 608126 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of WDHD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDHD1 | 11169 | 204728_s_at | 1.7216 | 0.0447 | |
| GSE20347 | WDHD1 | 11169 | 204728_s_at | 1.2761 | 0.0000 | |
| GSE23400 | WDHD1 | 11169 | 204728_s_at | 0.4801 | 0.0000 | |
| GSE26886 | WDHD1 | 11169 | 204728_s_at | 1.6757 | 0.0000 | |
| GSE29001 | WDHD1 | 11169 | 204728_s_at | 1.6947 | 0.0000 | |
| GSE38129 | WDHD1 | 11169 | 204728_s_at | 1.4630 | 0.0000 | |
| GSE45670 | WDHD1 | 11169 | 204728_s_at | 1.5133 | 0.0000 | |
| GSE53622 | WDHD1 | 11169 | 19905 | 1.4515 | 0.0000 | |
| GSE53624 | WDHD1 | 11169 | 19905 | 2.0605 | 0.0000 | |
| GSE63941 | WDHD1 | 11169 | 216228_s_at | 2.6469 | 0.0001 | |
| GSE77861 | WDHD1 | 11169 | 204728_s_at | 0.6688 | 0.0215 | |
| GSE97050 | WDHD1 | 11169 | A_23_P25873 | 1.1326 | 0.0620 | |
| SRP007169 | WDHD1 | 11169 | RNAseq | 2.5031 | 0.0000 | |
| SRP008496 | WDHD1 | 11169 | RNAseq | 2.3495 | 0.0000 | |
| SRP064894 | WDHD1 | 11169 | RNAseq | 1.5159 | 0.0000 | |
| SRP133303 | WDHD1 | 11169 | RNAseq | 1.4809 | 0.0000 | |
| SRP159526 | WDHD1 | 11169 | RNAseq | 1.1381 | 0.0032 | |
| SRP193095 | WDHD1 | 11169 | RNAseq | 1.1150 | 0.0000 | |
| SRP219564 | WDHD1 | 11169 | RNAseq | 2.0265 | 0.0013 | |
| TCGA | WDHD1 | 11169 | RNAseq | 0.9731 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by WDHD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDHD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDHD1 | 11169 | 8 | 3 | 19 | |
| GSE20123 | WDHD1 | 11169 | 8 | 3 | 19 | |
| GSE43470 | WDHD1 | 11169 | 9 | 1 | 33 | |
| GSE46452 | WDHD1 | 11169 | 16 | 3 | 40 | |
| GSE47630 | WDHD1 | 11169 | 11 | 10 | 19 | |
| GSE54993 | WDHD1 | 11169 | 3 | 8 | 59 | |
| GSE54994 | WDHD1 | 11169 | 19 | 4 | 30 | |
| GSE60625 | WDHD1 | 11169 | 0 | 2 | 9 | |
| GSE74703 | WDHD1 | 11169 | 8 | 1 | 27 | |
| GSE74704 | WDHD1 | 11169 | 3 | 2 | 15 | |
| TCGA | WDHD1 | 11169 | 32 | 14 | 50 |
Total number of gains: 117; Total number of losses: 51; Total Number of normals: 320.
Somatic mutations of WDHD1:
Generating mutation plots.
Highly correlated genes for WDHD1:
Showing top 20/2117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDHD1 | CDKN3 | 0.860905 | 13 | 0 | 13 |
| WDHD1 | DLGAP5 | 0.859362 | 12 | 0 | 12 |
| WDHD1 | KIF2C | 0.827908 | 12 | 0 | 12 |
| WDHD1 | UBE2C | 0.82134 | 12 | 0 | 12 |
| WDHD1 | GINS1 | 0.821102 | 12 | 0 | 12 |
| WDHD1 | STIL | 0.808309 | 12 | 0 | 12 |
| WDHD1 | HJURP | 0.808096 | 12 | 0 | 12 |
| WDHD1 | NCAPH | 0.806797 | 9 | 0 | 9 |
| WDHD1 | EBNA1BP2 | 0.803835 | 3 | 0 | 3 |
| WDHD1 | KIF20A | 0.8019 | 12 | 0 | 12 |
| WDHD1 | MYBL2 | 0.799399 | 12 | 0 | 12 |
| WDHD1 | FAM89A | 0.796616 | 3 | 0 | 3 |
| WDHD1 | EME1 | 0.794269 | 6 | 0 | 6 |
| WDHD1 | GMNN | 0.791691 | 13 | 0 | 13 |
| WDHD1 | TPX2 | 0.791332 | 13 | 0 | 12 |
| WDHD1 | VRK1 | 0.79115 | 13 | 0 | 13 |
| WDHD1 | RACGAP1 | 0.790269 | 11 | 0 | 11 |
| WDHD1 | CBX3 | 0.788507 | 10 | 0 | 10 |
| WDHD1 | BLM | 0.785912 | 12 | 0 | 12 |
| WDHD1 | PLEKHH1 | 0.784411 | 3 | 0 | 3 |
For details and further investigation, click here
