| Full name: minichromosome maintenance 10 replication initiation factor | Alias Symbol: PRO2249|CNA43|DNA43 | ||
| Type: protein-coding gene | Cytoband: 10p13 | ||
| Entrez ID: 55388 | HGNC ID: HGNC:18043 | Ensembl Gene: ENSG00000065328 | OMIM ID: 609357 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MCM10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCM10 | 55388 | 220651_s_at | 1.7871 | 0.0262 | |
| GSE20347 | MCM10 | 55388 | 220651_s_at | 1.7390 | 0.0000 | |
| GSE23400 | MCM10 | 55388 | 220651_s_at | 1.0363 | 0.0000 | |
| GSE26886 | MCM10 | 55388 | 223570_at | 0.5346 | 0.0313 | |
| GSE29001 | MCM10 | 55388 | 220651_s_at | 1.4502 | 0.0019 | |
| GSE38129 | MCM10 | 55388 | 220651_s_at | 2.0064 | 0.0000 | |
| GSE45670 | MCM10 | 55388 | 220651_s_at | 2.0585 | 0.0000 | |
| GSE53622 | MCM10 | 55388 | 109098 | 0.9336 | 0.0000 | |
| GSE53624 | MCM10 | 55388 | 109098 | 1.2185 | 0.0000 | |
| GSE63941 | MCM10 | 55388 | 220651_s_at | 3.7750 | 0.0000 | |
| GSE77861 | MCM10 | 55388 | 223570_at | 0.0856 | 0.4646 | |
| GSE97050 | MCM10 | 55388 | A_33_P3867534 | 0.9935 | 0.0555 | |
| SRP007169 | MCM10 | 55388 | RNAseq | 2.8167 | 0.0000 | |
| SRP008496 | MCM10 | 55388 | RNAseq | 2.1963 | 0.0000 | |
| SRP064894 | MCM10 | 55388 | RNAseq | 1.1391 | 0.0001 | |
| SRP133303 | MCM10 | 55388 | RNAseq | 1.2348 | 0.0000 | |
| SRP159526 | MCM10 | 55388 | RNAseq | 1.6124 | 0.0008 | |
| SRP193095 | MCM10 | 55388 | RNAseq | 1.0567 | 0.0000 | |
| SRP219564 | MCM10 | 55388 | RNAseq | 1.4499 | 0.0238 | |
| TCGA | MCM10 | 55388 | RNAseq | 1.6488 | 0.0000 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by MCM10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCM10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCM10 | 55388 | 6 | 7 | 17 | |
| GSE20123 | MCM10 | 55388 | 6 | 6 | 18 | |
| GSE43470 | MCM10 | 55388 | 3 | 5 | 35 | |
| GSE46452 | MCM10 | 55388 | 2 | 14 | 43 | |
| GSE47630 | MCM10 | 55388 | 6 | 14 | 20 | |
| GSE54993 | MCM10 | 55388 | 11 | 1 | 58 | |
| GSE54994 | MCM10 | 55388 | 4 | 9 | 40 | |
| GSE60625 | MCM10 | 55388 | 0 | 0 | 11 | |
| GSE74703 | MCM10 | 55388 | 2 | 3 | 31 | |
| GSE74704 | MCM10 | 55388 | 1 | 5 | 14 | |
| TCGA | MCM10 | 55388 | 21 | 24 | 51 |
Total number of gains: 62; Total number of losses: 88; Total Number of normals: 338.
Somatic mutations of MCM10:
Generating mutation plots.
Highly correlated genes for MCM10:
Showing top 20/1828 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCM10 | TPX2 | 0.811152 | 11 | 0 | 11 |
| MCM10 | NCAPH | 0.804162 | 9 | 0 | 8 |
| MCM10 | FOXM1 | 0.803268 | 10 | 0 | 10 |
| MCM10 | EXO1 | 0.79962 | 11 | 0 | 11 |
| MCM10 | PRELID1 | 0.794146 | 3 | 0 | 3 |
| MCM10 | ORAI1 | 0.793373 | 4 | 0 | 4 |
| MCM10 | CCNB2 | 0.792985 | 11 | 0 | 10 |
| MCM10 | KIF18B | 0.790381 | 9 | 0 | 9 |
| MCM10 | NCAPG2 | 0.789665 | 10 | 0 | 10 |
| MCM10 | SPAG5 | 0.789504 | 11 | 0 | 11 |
| MCM10 | NEK2 | 0.787218 | 12 | 0 | 12 |
| MCM10 | BUB1 | 0.786657 | 11 | 0 | 9 |
| MCM10 | TTK | 0.785312 | 12 | 0 | 11 |
| MCM10 | DBF4 | 0.783309 | 11 | 0 | 11 |
| MCM10 | UCK2 | 0.782369 | 3 | 0 | 3 |
| MCM10 | KIF14 | 0.782033 | 11 | 0 | 11 |
| MCM10 | SPC25 | 0.781604 | 10 | 0 | 10 |
| MCM10 | CDKN3 | 0.781057 | 12 | 0 | 12 |
| MCM10 | DTL | 0.779799 | 12 | 0 | 12 |
| MCM10 | NUF2 | 0.779771 | 8 | 0 | 8 |
For details and further investigation, click here
