RFWD3

 

Full name: ring finger and WD repeat domain 3 Alias Symbol: FLJ10520|RNF201|FANCW
Type: protein-coding gene Cytoband: 16q23.1
Entrez ID: 55159 HGNC ID: HGNC:25539 Ensembl Gene: ENSG00000168411 OMIM ID: 614151
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of RFWD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RFWD3 55159 218564_at 1.4220 0.0300
GSE20347 RFWD3 55159 218564_at 0.7318 0.0000
GSE23400 RFWD3 55159 218564_at 0.6637 0.0000
GSE26886 RFWD3 55159 218564_at 0.0593 0.8458
GSE29001 RFWD3 55159 218564_at 0.7241 0.0133
GSE38129 RFWD3 55159 218564_at 1.0361 0.0000
GSE45670 RFWD3 55159 218564_at 0.9055 0.0000
GSE53622 RFWD3 55159 130205 0.8867 0.0000
GSE53624 RFWD3 55159 130205 0.8192 0.0000
GSE63941 RFWD3 55159 218564_at 0.7714 0.0391
GSE77861 RFWD3 55159 218564_at 0.5737 0.0144
GSE97050 RFWD3 55159 A_24_P287826 0.6144 0.1910
SRP007169 RFWD3 55159 RNAseq 1.2158 0.0035
SRP008496 RFWD3 55159 RNAseq 1.1036 0.0015
SRP064894 RFWD3 55159 RNAseq 0.2495 0.2697
SRP133303 RFWD3 55159 RNAseq 0.8363 0.0000
SRP159526 RFWD3 55159 RNAseq 0.8755 0.0000
SRP193095 RFWD3 55159 RNAseq 0.7105 0.0000
SRP219564 RFWD3 55159 RNAseq 0.3451 0.5076
TCGA RFWD3 55159 RNAseq 0.3812 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by RFWD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RFWD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RFWD3 55159 6 1 23
GSE20123 RFWD3 55159 6 1 23
GSE43470 RFWD3 55159 2 8 33
GSE46452 RFWD3 55159 37 2 20
GSE47630 RFWD3 55159 11 8 21
GSE54993 RFWD3 55159 2 4 64
GSE54994 RFWD3 55159 8 10 35
GSE60625 RFWD3 55159 4 0 7
GSE74703 RFWD3 55159 2 5 29
GSE74704 RFWD3 55159 3 0 17
TCGA RFWD3 55159 25 15 56

Total number of gains: 106; Total number of losses: 54; Total Number of normals: 328.  

 

Somatic mutations of RFWD3:

 

Generating mutation plots.

 

Highly correlated genes for RFWD3:

 

Showing top 20/1840 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RFWD3BUB10.7917361009
RFWD3UCK20.789885303
RFWD3RNF1490.770676303
RFWD3ORAI10.763707303
RFWD3KLHL130.762897303
RFWD3MCM100.75658710010
RFWD3MASTL0.755977505
RFWD3LRRC580.748839404
RFWD3SMAD10.748704303
RFWD3CENPBD10.742928404
RFWD3NUDT50.741511404
RFWD3GINS10.74124111011
RFWD3DHRS130.740328303
RFWD3MMS22L0.739834303
RFWD3CPSF60.739191909
RFWD3KPNA20.737548908
RFWD3CENPN0.73582212011
RFWD3FAM89A0.729707303
RFWD3DTL0.72950512011
RFWD3PSMG30.726401505

For details and further investigation, click here