| Full name: ORAI calcium release-activated calcium modulator 2 | Alias Symbol: CBCIP2|FLJ12474|FLJ14733|H_NH0514P08.8 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 80228 | HGNC ID: HGNC:21667 | Ensembl Gene: ENSG00000160991 | OMIM ID: 610929 |
| Drug and gene relationship at DGIdb | |||
ORAI2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of ORAI2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORAI2 | 80228 | 1558426_x_at | 0.7104 | 0.1033 | |
| GSE20347 | ORAI2 | 80228 | 218811_at | -0.0464 | 0.6203 | |
| GSE23400 | ORAI2 | 80228 | 218811_at | -0.1048 | 0.0029 | |
| GSE26886 | ORAI2 | 80228 | 1558426_x_at | 0.5313 | 0.0228 | |
| GSE29001 | ORAI2 | 80228 | 218811_at | -0.0134 | 0.9252 | |
| GSE38129 | ORAI2 | 80228 | 218811_at | -0.0595 | 0.5213 | |
| GSE45670 | ORAI2 | 80228 | 1558426_x_at | 0.3763 | 0.0074 | |
| GSE53622 | ORAI2 | 80228 | 80401 | 0.4501 | 0.0000 | |
| GSE53624 | ORAI2 | 80228 | 80401 | 0.4651 | 0.0000 | |
| GSE63941 | ORAI2 | 80228 | 1558426_x_at | -1.0661 | 0.0003 | |
| GSE77861 | ORAI2 | 80228 | 1558426_x_at | 0.7380 | 0.0786 | |
| GSE97050 | ORAI2 | 80228 | A_24_P329353 | 0.7211 | 0.1440 | |
| SRP007169 | ORAI2 | 80228 | RNAseq | 0.8703 | 0.0528 | |
| SRP008496 | ORAI2 | 80228 | RNAseq | 0.6828 | 0.0129 | |
| SRP064894 | ORAI2 | 80228 | RNAseq | 1.0923 | 0.0000 | |
| SRP133303 | ORAI2 | 80228 | RNAseq | 0.2989 | 0.0243 | |
| SRP159526 | ORAI2 | 80228 | RNAseq | 0.5890 | 0.1357 | |
| SRP193095 | ORAI2 | 80228 | RNAseq | 0.3048 | 0.0094 | |
| SRP219564 | ORAI2 | 80228 | RNAseq | 0.8758 | 0.0011 | |
| TCGA | ORAI2 | 80228 | RNAseq | 0.1732 | 0.0941 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ORAI2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ORAI2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORAI2 | 80228 | 14 | 0 | 16 | |
| GSE20123 | ORAI2 | 80228 | 13 | 0 | 17 | |
| GSE43470 | ORAI2 | 80228 | 6 | 3 | 34 | |
| GSE46452 | ORAI2 | 80228 | 10 | 1 | 48 | |
| GSE47630 | ORAI2 | 80228 | 7 | 3 | 30 | |
| GSE54993 | ORAI2 | 80228 | 1 | 10 | 59 | |
| GSE54994 | ORAI2 | 80228 | 15 | 4 | 34 | |
| GSE60625 | ORAI2 | 80228 | 0 | 0 | 11 | |
| GSE74703 | ORAI2 | 80228 | 6 | 2 | 28 | |
| GSE74704 | ORAI2 | 80228 | 10 | 0 | 10 | |
| TCGA | ORAI2 | 80228 | 53 | 6 | 37 |
Total number of gains: 135; Total number of losses: 29; Total Number of normals: 324.
Somatic mutations of ORAI2:
Generating mutation plots.
Highly correlated genes for ORAI2:
Showing top 20/332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORAI2 | DDX59 | 0.846823 | 4 | 0 | 4 |
| ORAI2 | CMBL | 0.831945 | 5 | 0 | 5 |
| ORAI2 | TNRC6C-AS1 | 0.759735 | 4 | 0 | 4 |
| ORAI2 | C9orf64 | 0.744171 | 6 | 0 | 6 |
| ORAI2 | CCDC152 | 0.714073 | 6 | 0 | 5 |
| ORAI2 | NLN | 0.712597 | 6 | 0 | 5 |
| ORAI2 | FUT8-AS1 | 0.70863 | 4 | 0 | 4 |
| ORAI2 | ZNF611 | 0.703196 | 7 | 0 | 6 |
| ORAI2 | CTDNEP1 | 0.702775 | 3 | 0 | 3 |
| ORAI2 | TMEM181 | 0.700889 | 3 | 0 | 3 |
| ORAI2 | SLC22A3 | 0.693664 | 6 | 0 | 5 |
| ORAI2 | SLC35E1 | 0.688781 | 7 | 0 | 5 |
| ORAI2 | GTF2H3 | 0.683028 | 5 | 0 | 4 |
| ORAI2 | FBXL18 | 0.682172 | 3 | 0 | 3 |
| ORAI2 | IRS4 | 0.671317 | 5 | 0 | 5 |
| ORAI2 | P2RY4 | 0.670951 | 4 | 0 | 4 |
| ORAI2 | WDPCP | 0.665516 | 6 | 0 | 5 |
| ORAI2 | FAM161B | 0.665062 | 5 | 0 | 3 |
| ORAI2 | TMEM87B | 0.664075 | 4 | 0 | 3 |
| ORAI2 | ALKBH6 | 0.663281 | 3 | 0 | 3 |
For details and further investigation, click here
