| Full name: ORMDL sphingolipid biosynthesis regulator 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.1 | ||
| Entrez ID: 94103 | HGNC ID: HGNC:16038 | Ensembl Gene: ENSG00000172057 | OMIM ID: 610075 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ORMDL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORMDL3 | 94103 | 223259_at | -0.0871 | 0.8226 | |
| GSE26886 | ORMDL3 | 94103 | 223259_at | -0.0205 | 0.9327 | |
| GSE45670 | ORMDL3 | 94103 | 223259_at | -0.1298 | 0.4754 | |
| GSE53622 | ORMDL3 | 94103 | 39986 | -0.1379 | 0.0627 | |
| GSE53624 | ORMDL3 | 94103 | 94915 | 0.0278 | 0.7033 | |
| GSE63941 | ORMDL3 | 94103 | 223259_at | -0.4828 | 0.2384 | |
| GSE77861 | ORMDL3 | 94103 | 223259_at | 0.0050 | 0.9630 | |
| GSE97050 | ORMDL3 | 94103 | A_23_P38190 | 0.4042 | 0.2613 | |
| SRP007169 | ORMDL3 | 94103 | RNAseq | 0.4477 | 0.2885 | |
| SRP008496 | ORMDL3 | 94103 | RNAseq | 0.3474 | 0.2856 | |
| SRP064894 | ORMDL3 | 94103 | RNAseq | 0.2132 | 0.3876 | |
| SRP133303 | ORMDL3 | 94103 | RNAseq | 0.1115 | 0.6139 | |
| SRP159526 | ORMDL3 | 94103 | RNAseq | 0.1351 | 0.5920 | |
| SRP193095 | ORMDL3 | 94103 | RNAseq | -0.0909 | 0.5106 | |
| SRP219564 | ORMDL3 | 94103 | RNAseq | -0.2724 | 0.4815 | |
| TCGA | ORMDL3 | 94103 | RNAseq | -0.1427 | 0.0087 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ORMDL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ORMDL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORMDL3 | 94103 | 9 | 1 | 20 | |
| GSE20123 | ORMDL3 | 94103 | 9 | 1 | 20 | |
| GSE43470 | ORMDL3 | 94103 | 1 | 2 | 40 | |
| GSE46452 | ORMDL3 | 94103 | 34 | 0 | 25 | |
| GSE47630 | ORMDL3 | 94103 | 8 | 1 | 31 | |
| GSE54993 | ORMDL3 | 94103 | 3 | 4 | 63 | |
| GSE54994 | ORMDL3 | 94103 | 9 | 5 | 39 | |
| GSE60625 | ORMDL3 | 94103 | 4 | 0 | 7 | |
| GSE74703 | ORMDL3 | 94103 | 1 | 1 | 34 | |
| GSE74704 | ORMDL3 | 94103 | 5 | 1 | 14 | |
| TCGA | ORMDL3 | 94103 | 23 | 8 | 65 |
Total number of gains: 106; Total number of losses: 24; Total Number of normals: 358.
Somatic mutations of ORMDL3:
Generating mutation plots.
Highly correlated genes for ORMDL3:
Showing top 20/270 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORMDL3 | LSM10 | 0.766388 | 3 | 0 | 3 |
| ORMDL3 | TMEM50A | 0.761474 | 3 | 0 | 3 |
| ORMDL3 | RPL19 | 0.754218 | 4 | 0 | 4 |
| ORMDL3 | LRRC55 | 0.747351 | 3 | 0 | 3 |
| ORMDL3 | NLK | 0.739983 | 3 | 0 | 3 |
| ORMDL3 | OS9 | 0.734032 | 3 | 0 | 3 |
| ORMDL3 | CDC26 | 0.72826 | 3 | 0 | 3 |
| ORMDL3 | SIDT2 | 0.726329 | 3 | 0 | 3 |
| ORMDL3 | CLEC14A | 0.718988 | 4 | 0 | 4 |
| ORMDL3 | TCN2 | 0.718305 | 3 | 0 | 3 |
| ORMDL3 | ARL2BP | 0.713925 | 3 | 0 | 3 |
| ORMDL3 | TBC1D9B | 0.713683 | 3 | 0 | 3 |
| ORMDL3 | ZNF830 | 0.708927 | 4 | 0 | 3 |
| ORMDL3 | NOTCH2 | 0.7076 | 3 | 0 | 3 |
| ORMDL3 | SSNA1 | 0.703195 | 3 | 0 | 3 |
| ORMDL3 | PLEKHM1 | 0.702592 | 3 | 0 | 3 |
| ORMDL3 | TXNDC11 | 0.702475 | 3 | 0 | 3 |
| ORMDL3 | AXL | 0.699222 | 3 | 0 | 3 |
| ORMDL3 | BECN1 | 0.696328 | 3 | 0 | 3 |
| ORMDL3 | UQCRFS1 | 0.69617 | 3 | 0 | 3 |
For details and further investigation, click here
