| Full name: transcobalamin 2 | Alias Symbol: D22S676|D22S750|TC2 | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 6948 | HGNC ID: HGNC:11653 | Ensembl Gene: ENSG00000185339 | OMIM ID: 613441 |
| Drug and gene relationship at DGIdb | |||
Expression of TCN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCN2 | 6948 | 204043_at | 0.0375 | 0.9518 | |
| GSE20347 | TCN2 | 6948 | 204043_at | 0.0144 | 0.8653 | |
| GSE23400 | TCN2 | 6948 | 204043_at | -0.0453 | 0.2171 | |
| GSE26886 | TCN2 | 6948 | 204043_at | 0.4551 | 0.0095 | |
| GSE29001 | TCN2 | 6948 | 204043_at | -0.0017 | 0.9921 | |
| GSE38129 | TCN2 | 6948 | 204043_at | -0.0930 | 0.4050 | |
| GSE45670 | TCN2 | 6948 | 204043_at | 0.0693 | 0.5415 | |
| GSE53622 | TCN2 | 6948 | 22442 | 0.4193 | 0.0168 | |
| GSE53624 | TCN2 | 6948 | 22442 | 0.8075 | 0.0000 | |
| GSE63941 | TCN2 | 6948 | 204043_at | -0.2349 | 0.6925 | |
| GSE77861 | TCN2 | 6948 | 204043_at | 0.0424 | 0.6182 | |
| GSE97050 | TCN2 | 6948 | A_23_P40611 | 0.5198 | 0.2637 | |
| SRP007169 | TCN2 | 6948 | RNAseq | 3.2472 | 0.0000 | |
| SRP008496 | TCN2 | 6948 | RNAseq | 3.1303 | 0.0000 | |
| SRP064894 | TCN2 | 6948 | RNAseq | 1.3193 | 0.0021 | |
| SRP133303 | TCN2 | 6948 | RNAseq | 0.3525 | 0.2859 | |
| SRP159526 | TCN2 | 6948 | RNAseq | 1.0682 | 0.0045 | |
| SRP193095 | TCN2 | 6948 | RNAseq | 0.7274 | 0.0448 | |
| SRP219564 | TCN2 | 6948 | RNAseq | 1.1680 | 0.1263 | |
| TCGA | TCN2 | 6948 | RNAseq | -0.3331 | 0.0121 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TCN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCN2 | 6948 | 4 | 5 | 21 | |
| GSE20123 | TCN2 | 6948 | 4 | 4 | 22 | |
| GSE43470 | TCN2 | 6948 | 4 | 5 | 34 | |
| GSE46452 | TCN2 | 6948 | 31 | 1 | 27 | |
| GSE47630 | TCN2 | 6948 | 8 | 5 | 27 | |
| GSE54993 | TCN2 | 6948 | 3 | 6 | 61 | |
| GSE54994 | TCN2 | 6948 | 11 | 8 | 34 | |
| GSE60625 | TCN2 | 6948 | 5 | 0 | 6 | |
| GSE74703 | TCN2 | 6948 | 4 | 5 | 27 | |
| GSE74704 | TCN2 | 6948 | 1 | 1 | 18 | |
| TCGA | TCN2 | 6948 | 27 | 15 | 54 |
Total number of gains: 102; Total number of losses: 55; Total Number of normals: 331.
Somatic mutations of TCN2:
Generating mutation plots.
Highly correlated genes for TCN2:
Showing top 20/786 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCN2 | C19orf38 | 0.747824 | 3 | 0 | 3 |
| TCN2 | CDC42SE2 | 0.739277 | 4 | 0 | 4 |
| TCN2 | C1orf68 | 0.737427 | 3 | 0 | 3 |
| TCN2 | NRROS | 0.729112 | 3 | 0 | 3 |
| TCN2 | ISOC2 | 0.72704 | 3 | 0 | 3 |
| TCN2 | CPT1C | 0.727025 | 3 | 0 | 3 |
| TCN2 | ZBTB25 | 0.724884 | 3 | 0 | 3 |
| TCN2 | FCGR3A | 0.723644 | 3 | 0 | 3 |
| TCN2 | TLR1 | 0.723188 | 4 | 0 | 4 |
| TCN2 | ORMDL3 | 0.718305 | 3 | 0 | 3 |
| TCN2 | CERKL | 0.712585 | 3 | 0 | 3 |
| TCN2 | EIF3L | 0.71252 | 3 | 0 | 3 |
| TCN2 | GNGT2 | 0.71157 | 4 | 0 | 3 |
| TCN2 | GBGT1 | 0.709607 | 5 | 0 | 5 |
| TCN2 | LRRC25 | 0.709419 | 3 | 0 | 3 |
| TCN2 | H6PD | 0.704668 | 3 | 0 | 3 |
| TCN2 | ITGB4 | 0.702325 | 3 | 0 | 3 |
| TCN2 | TNFSF8 | 0.70166 | 6 | 0 | 6 |
| TCN2 | EHMT2 | 0.699515 | 3 | 0 | 3 |
| TCN2 | CASC4 | 0.696974 | 3 | 0 | 3 |
For details and further investigation, click here
