| Full name: beclin 1 | Alias Symbol: ATG6|VPS30 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 8678 | HGNC ID: HGNC:1034 | Ensembl Gene: ENSG00000126581 | OMIM ID: 604378 |
| Drug and gene relationship at DGIdb | |||
Expression of BECN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BECN1 | 8678 | 208946_s_at | -0.4931 | 0.0842 | |
| GSE20347 | BECN1 | 8678 | 208946_s_at | -0.4436 | 0.0005 | |
| GSE23400 | BECN1 | 8678 | 208946_s_at | -0.0021 | 0.9746 | |
| GSE26886 | BECN1 | 8678 | 208946_s_at | -0.5378 | 0.0532 | |
| GSE29001 | BECN1 | 8678 | 208946_s_at | -0.4384 | 0.0893 | |
| GSE38129 | BECN1 | 8678 | 208946_s_at | -0.3611 | 0.0005 | |
| GSE45670 | BECN1 | 8678 | 208946_s_at | -0.1100 | 0.2850 | |
| GSE53622 | BECN1 | 8678 | 28056 | -0.1855 | 0.0017 | |
| GSE53624 | BECN1 | 8678 | 28056 | -0.2577 | 0.0000 | |
| GSE63941 | BECN1 | 8678 | 208946_s_at | -0.5061 | 0.0781 | |
| GSE77861 | BECN1 | 8678 | 208946_s_at | -0.1930 | 0.5137 | |
| GSE97050 | BECN1 | 8678 | A_23_P89410 | -0.2454 | 0.3726 | |
| SRP007169 | BECN1 | 8678 | RNAseq | -0.4928 | 0.1166 | |
| SRP008496 | BECN1 | 8678 | RNAseq | -0.4172 | 0.0251 | |
| SRP064894 | BECN1 | 8678 | RNAseq | -0.0066 | 0.9540 | |
| SRP133303 | BECN1 | 8678 | RNAseq | -0.0230 | 0.8109 | |
| SRP159526 | BECN1 | 8678 | RNAseq | -0.2443 | 0.4960 | |
| SRP193095 | BECN1 | 8678 | RNAseq | -0.3830 | 0.0000 | |
| SRP219564 | BECN1 | 8678 | RNAseq | -0.5233 | 0.1118 | |
| TCGA | BECN1 | 8678 | RNAseq | -0.1392 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BECN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BECN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BECN1 | 8678 | 6 | 2 | 22 | |
| GSE20123 | BECN1 | 8678 | 6 | 2 | 22 | |
| GSE43470 | BECN1 | 8678 | 1 | 2 | 40 | |
| GSE46452 | BECN1 | 8678 | 34 | 0 | 25 | |
| GSE47630 | BECN1 | 8678 | 8 | 1 | 31 | |
| GSE54993 | BECN1 | 8678 | 3 | 4 | 63 | |
| GSE54994 | BECN1 | 8678 | 8 | 5 | 40 | |
| GSE60625 | BECN1 | 8678 | 4 | 0 | 7 | |
| GSE74703 | BECN1 | 8678 | 1 | 1 | 34 | |
| GSE74704 | BECN1 | 8678 | 4 | 1 | 15 | |
| TCGA | BECN1 | 8678 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of BECN1:
Generating mutation plots.
Highly correlated genes for BECN1:
Showing top 20/643 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BECN1 | UBQLN1 | 0.852054 | 3 | 0 | 3 |
| BECN1 | INSIG1 | 0.789603 | 3 | 0 | 3 |
| BECN1 | YAP1 | 0.77899 | 3 | 0 | 3 |
| BECN1 | ARL6 | 0.774442 | 3 | 0 | 3 |
| BECN1 | FAM122A | 0.761452 | 4 | 0 | 4 |
| BECN1 | PDCD7 | 0.750977 | 3 | 0 | 3 |
| BECN1 | SWAP70 | 0.749323 | 3 | 0 | 3 |
| BECN1 | PNPLA8 | 0.741284 | 4 | 0 | 3 |
| BECN1 | PLEKHA5 | 0.732867 | 3 | 0 | 3 |
| BECN1 | CUL2 | 0.720023 | 3 | 0 | 3 |
| BECN1 | HIPK3 | 0.719424 | 3 | 0 | 3 |
| BECN1 | LARP4 | 0.716764 | 3 | 0 | 3 |
| BECN1 | SYPL1 | 0.714647 | 4 | 0 | 4 |
| BECN1 | UBE2Q2 | 0.709193 | 3 | 0 | 3 |
| BECN1 | LRRD1 | 0.706704 | 3 | 0 | 3 |
| BECN1 | RAB21 | 0.704285 | 4 | 0 | 3 |
| BECN1 | DLG1 | 0.702508 | 3 | 0 | 3 |
| BECN1 | PCGF3 | 0.701879 | 3 | 0 | 3 |
| BECN1 | ZNF700 | 0.698749 | 3 | 0 | 3 |
| BECN1 | ORMDL3 | 0.696328 | 3 | 0 | 3 |
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